日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Binding kinetics, bias, receptor internalization and effects on insulin secretion in vitro and in vivo of a novel GLP-1R/GIPR dual agonist, HISHS-2001

新型 GLP-1R/GIPR 双重激动剂 HISHS-2001 的结合动力学、偏向性、受体内化及其对体外和体内胰岛素分泌的影响

期刊:Diabetes Obesity & Metabolism
影响因子:5.4
doi:10.1111/dom.16652
Yusman Manchanda ，Ben Jones ，Gaelle Carrat ，Zenouska Ramchunder ，Piero Marchetti ，Isabelle Leclerc ，Rajamannar Thennati ，Vinod Burade ，Muthukumaran Natarajan ，Pradeep Shahi ，Alejandra Tomas ，Guy A Rutter
GLP-1
信号转导
GIP
免疫/内分泌
发表日期：2025
文献求助 收藏

Binding Kinetics, Bias, Receptor Internalization and Effects on Insulin Secretion in vitro and in vivo of a Novel GLP-1R/GIPR Dual Agonist, HISHS-2001

新型 GLP-1R/GIPR 双重激动剂的结合动力学、偏差、受体内化以及对体内和体外胰岛素分泌的影响，HISHS-2001

期刊:
影响因子:
doi:10.1101/2025.01.13.632834
Yusman Manchanda, Ben Jones, Gaelle Carrat, Zenouska Ramchunder, Piero Marchetti, Isabelle Leclerc, Rajamannar Thennati, Vinod Burade, Muthukumaran Natarajan, Pradeep Shahi, Alejandra Tomas, Guy A Rutter
信号转导
Insulin Receptor
发表日期：2025
文献求助 收藏

Roles for the long non-coding RNA Pax6os1/ PAX6-AS1 in pancreatic beta cell function

长链非编码RNA Pax6os1/PAX6-AS1在胰岛β细胞功能中的作用

期刊:iScience
影响因子:4.6
doi:10.1016/j.isci.2024.111518
Livia Lopez-Noriega ，Rebecca Callingham ，Aida Martinez-Sánchez ，Sameena Nawaz ，Grazia Pizza ，Nejc Haberman ，Nevena Cvetesic ，Marie-Sophie Nguyen-Tu ，Boris Lenhard ，Piero Marchetti ，Lorenzo Piemonti ，Eelco de Koning ，A M James Shapiro ，Paul R Johnson ，Isabelle Leclerc ，Benoit Hastoy ，Benoit R Gauthier ，Timothy J Pullen ，Guy A Rutter
细胞生物学
PAX6
发表日期：2024
文献求助 收藏

Underreporting of adverse events to health authorities by healthcare professionals: a red flag-raising descriptive study

医疗专业人员向卫生当局漏报不良事件：一项令人警醒的描述性研究

期刊:International Journal for Quality in Health Care
影响因子:2.2
doi:10.1093/intqhc/mzae109
Lavallée, Maude; Corbin, Sonia; Pradhan, Pallavi; Guefack, Laura Blonde; Thibault, Magalie; Méthot, Julie; Bérard, Anick; Piché, Marie-Eve; Gimenes, Fernanda Raphael Escobar; Darveau, Rosalie; Cloutier, Isabelle; Leclerc, Jacinthe
发表日期：2024
文献求助 收藏

Impact of Vanessa's Law on the Reporting of Serious Adverse Events: A Retrospective Study Among Antiplatelet Users in a Tertiary-Care Cardiology Centre

瓦妮莎法案对严重不良事件报告的影响：一项针对三级心脏病中心抗血小板药物使用者的回顾性研究

期刊:CJC Open
影响因子:1.9
doi:10.1016/j.cjco.2024.09.003
Guefack Djiokeng, Laura Blonde; Todkar, Shweta; Corbin, Sonia; Lavallée, Maude; Pradhan, Pallavi; Thibault, Magalie; Piché, Marie-Eve; Méthot, Julie; Bérard, Anick; Gonella, Jennifer Midiani; Escobar Gimenes, Fernanda Raphael; Darveau, Rosalie; Cloutier, Isabelle; Leclerc, Jacinthe
血小板
心脏病
心血管
发表日期：2024
文献求助 收藏

Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase

急性和慢性刺激 AMP 活化蛋白激酶对调节胰岛素分泌的相反作用

期刊:Diabetologia
影响因子:8.4
doi:10.1007/s00125-022-05673-x
Marie-Sophie Nguyen-Tu, Joseph Harris, Aida Martinez-Sanchez, Pauline Chabosseau, Ming Hu, Eleni Georgiadou, Alice Pollard, Pablo Otero, Livia Lopez-Noriega, Isabelle Leclerc, Kei Sakamoto, Dieter Schmoll, David M Smith, David Carling, Guy A Rutter
信号转导
WB
发表日期：2022
文献求助 收藏

In vivo and in vitro characterization of GL0034, a novel long-acting glucagon-like peptide-1 receptor agonist

新型长效胰高血糖素样肽-1受体激动剂GL0034的体内和体外表征

期刊:Diabetes Obesity & Metabolism
影响因子:5.4
doi:10.1111/dom.14794
Ben Jones, Vinod Burade, Elina Akalestou, Yusman Manchanda, Zenouska Ramchunder, Gaëlle Carrat, Marie-Sophie Nguyen-Tu, Piero Marchetti, Lorenzo Piemonti, Isabelle Leclerc, Rajamannar Thennati, Tina Vilsboll, Bernard Thorens, Alejandra Tomas, Guy A Rutter
信号转导
发表日期：2022
文献求助 收藏

Adipocyte-specific deletion of Tcf7l2 induces dysregulated lipid metabolism and impairs glucose tolerance in mice

脂肪细胞特异性缺失 Tcf7l2 可导致小鼠脂质代谢失调并损害葡萄糖耐受性

期刊:Diabetologia
影响因子:8.4
doi:10.1007/s00125-020-05292-4
Marie-Sophie Nguyen-Tu, Aida Martinez-Sanchez, Isabelle Leclerc, Guy A Rutter, Gabriela da Silva Xavier
代谢
其它细胞
WB
发表日期：2021
文献求助 收藏

The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice

线粒体 Ca2+ 单向转运体的成孔亚基 MCU 是小鼠体内和体外正常葡萄糖刺激的胰岛素分泌所必需的

期刊:Diabetologia
影响因子:8.4
doi:10.1007/s00125-020-05148-x
Eleni Georgiadou, Elizabeth Haythorne, Matthew T Dickerson, Livia Lopez-Noriega, Timothy J Pullen, Gabriela da Silva Xavier, Samuel P X Davis, Aida Martinez-Sanchez, Francesca Semplici, Rosario Rizzuto, James A McGinty, Paul M French, Matthew C Cane, David A Jacobson, Isabelle Leclerc, Guy A Rutter
信号转导
发表日期：2020
文献求助 收藏

The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis

2型糖尿病基因产物STARD10是一种磷脂酰肌醇结合蛋白，可控制胰岛素分泌颗粒的生物合成。

期刊:Molecular Metabolism
影响因子:7
doi:10.1016/j.molmet.2020.101015
Gaelle R Carrat,Elizabeth Haythorne,Alejandra Tomas,Leena Haataja,Andreas Müller,Peter Arvan,Alexandra Piunti,Kaiying Cheng,Mutian Huang,Timothy J Pullen,Eleni Georgiadou,Theodoros Stylianides,Nur Shabrina Amirruddin,Victoria Salem,Walter Distaso,Andrew Cakebread,Kate J Heesom,Philip A Lewis,David J Hodson,Linford J Briant,Annie C H Fung,Richard B Sessions,Fabien Alpy,Alice P S Kong,Peter I Benke,Federico Torta,Adrian Kee Keong Teo,Isabelle Leclerc,Michele Solimena,Dale B Wigley,Guy A Rutter
糖尿病
STAR
发表日期：2020
文献求助 收藏