日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Multiple immunofluorescence labelling of formalin-fixed paraffin-embedded (FFPE) tissue

福尔马林固定石蜡包埋 (FFPE) 组织的多重免疫荧光标记

David Robertson, Kay Savage, Jorge S Reis-Filho, Clare M Isacke

Targeting Transcriptional Regulation with a CDK9 Inhibitor Suppresses Growth of Endocrine- and Palbociclib-Resistant ER+ Breast Cancers

使用 CDK9 抑制剂靶向转录调控可抑制内分泌和哌柏西利耐药 ER+ 乳腺癌的生长

Arany Soosainathan, Marjan Iravani, Rania El-Botty, John Alexander, Laura Sourd, Ludivine Morisset, Pierre Painsec, Rebecca Orha, Joanna Nikitorowicz-Buniak, Sunil Pancholi, Syed Haider, Mitch Dowsett, Elisabetta Marangoni, Lesley-Ann Martin, Clare M Isacke

Targeting the activated microenvironment with endosialin (CD248)-directed CAR-T cells ablates perivascular cells to impair tumor growth and metastasis

利用靶向内皮唾液酸蛋白(CD248)的CAR-T细胞攻击活化的微环境,可清除血管周围细胞,从而抑制肿瘤生长和转移。

Sarah L Ash ,Rebecca Orha ,Holly Mole ,Meg Dinesh-Kumar ,Steven P Lee ,Frances K Turrell # ,Clare M Isacke #

Pathway-based signatures predict patient outcome, chemotherapy benefit and synthetic lethal dependencies in invasive lobular breast cancer

基于通路特征的基因表达谱可预测浸润性小叶癌患者的预后、化疗获益和合成致死依赖性

Alexander, John; Schipper, Koen; Nash, Sarah; Brough, Rachel; Kemp, Harriet; Iacovacci, Jacopo; Isacke, Clare; Natrajan, Rachael; Sawyer, Elinor; Lord, Christopher J; Haider, Syed

Age-associated microenvironmental changes highlight the role of PDGF-C in ER+ breast cancer metastatic relapse

与年龄相关的微环境变化凸显了 PDGF-C 在 ER+ 乳腺癌转移性复发中的作用

Frances K Turrell, Rebecca Orha, Naomi J Guppy, Andrea Gillespie, Matthew Guelbert, Chris Starling, Syed Haider, Clare M Isacke

Genomic profiling and pre-clinical modelling of breast cancer leptomeningeal metastasis reveals acquisition of a lobular-like phenotype

乳腺癌软脑膜转移的基因组分析和临床前建模揭示了小叶样表型的获得

Amanda Fitzpatrick, Marjan Iravani, Adam Mills, David Vicente, Thanussuyah Alaguthurai, Ioannis Roxanis, Nicholas C Turner, Syed Haider, Andrew N J Tutt, Clare M Isacke

Endo180 (MRC2) Antibody-Drug Conjugate for the Treatment of Sarcoma

Endo180(MRC2)抗体药物偶联物用于治疗肉瘤

Rachel J Evans, Douglas W Perkins, Joanna Selfe, Anna Kelsey, Gavin P Birch, Janet M Shipley, Koen Schipper, Clare M Isacke

Therapy-induced normal tissue damage promotes breast cancer metastasis

治疗引起的正常组织损伤促进乳腺癌转移

Douglas W Perkins, Ivana Steiner, Syed Haider, David Robertson, Richard Buus, Lynda O'Leary, Clare M Isacke

Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment

基质抑癌素M细胞因子通过重编程肿瘤微环境促进乳腺癌进展

Araujo, Angela M; Abaurrea, Andrea; Azcoaga, Peio; López-Velazco, Joanna I; Manzano, Sara; Rodriguez, Javier; Rezola, Ricardo; Egia-Mendikute, Leire; Valdés-Mora, Fátima; Flores, Juana M; Jenkins, Liam; Pulido, Laura; Osorio-Querejeta, Iñaki; Fernández-Nogueira, Patricia; Ferrari, Nicola; Viera, Cristina; Martín-Martín, Natalia; Tzankov, Alexandar; Eppenberger-Castori, Serenella; Alvarez-Lopez, Isabel; Urruticoechea, Ander; Bragado, Paloma; Coleman, Nicholas; Palazón, Asís; Carracedo, Arkaitz; Gallego-Ortega, David; Calvo, Fernando; Isacke, Clare M; Caffarel, María M; Lawrie, Charles H

Correction: Loss of E-cadherin leads to Id2-dependent inhibition of cell cycle progression in metastatic lobular breast cancer

更正:E-钙黏蛋白的缺失导致转移性小叶乳腺癌中Id2依赖性细胞周期进程抑制

Rätze, Max A K; Koorman, Thijs; Sijnesael, Thijmen; Bassey-Archibong, Blessing; van de Ven, Robert; Enserink, Lotte; Visser, Daan; Jaksani, Sridevi; Viciano, Ignacio; Bakker, Elvira R M; Richard, François; Tutt, Andrew; O'Leary, Lynda; Fitzpatrick, Amanda; Roca-Cusachs, Pere; van Diest, Paul J; Desmedt, Christine; Daniel, Juliet M; Isacke, Clare M; Derksen, Patrick W B