日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Eighteen million years of diverse enamel proteomes from the East African Rift

来自东非大裂谷的1800万年来多样化的牙釉质蛋白质组

Green, Daniel R; Uno, Kevin T; Miller, Ellen R; Feibel, Craig S; Aoron, Eipa Emmanuel; Beck, Catherine C; Grossman, Aryeh; Kirera, Francis M; Kirinya, Martin M; Leakey, Louise N; Liutkus-Pierce, Cynthia; Manthi, Fredrick K; Ndiema, Emmanuel K; Nengo, Isaiah O; Nyete, Cyprian; Rowan, John; Russo, Gabrielle A; Sanders, William J; Smiley, Tara M; Princehouse, Patricia; Vitek, Natasha S; Cleland, Timothy P

APOE4 to APOE2 allelic switching in mice improves Alzheimer's disease-related metabolic signatures, neuropathology and cognition.

小鼠中 APOE4 到 APOE2 等位基因转换可改善阿尔茨海默病相关的代谢特征、神经病理学和认知能力。

Golden Lesley R, Siano Dahlia S, Stephens Isaiah O, MacLean Steven M, Saito Kai, Nolt Georgia L, Funnell Jessica L, Pallerla Akhil V, Lee Sangderk, Smith Cathryn, Chen Jing, Zhu Haining, Voy Clairity, Whitus Callie M, Hernandez Gabriela, Farmer Brandon C, Pandya Kumar, Cowley Dale O, Macauley Shannon L, Gordon Scott M, Morganti Josh M, Johnson Lance A

Microglia-derived APOE2 improves remyelination even in the presence of endogenous APOE4.

即使在存在内源性 APOE4 的情况下,小胶质细胞衍生的 APOE2 也能改善髓鞘再生。

Nolt Georgia L, Golden Lesley R, Thorpe Shealee P, Funnell Jessica L, Stephens Isaiah O, Hernandez Gabriela, MacLean Steven M, Lucido Chloe C, Brock Chesney R, Pallerla Akhil V, Adreon Darcy R, Williams Holden C, Morganti Josh M, Johnson Lance A

APOE4 reshapes the lipid droplet proteome and modulates microglial inflammatory responses

APOE4 重塑脂滴蛋白质组并调节小胶质细胞炎症反应

Friday, Cassi M; Stephens, Isaiah O; Smith, Cathryn T; Lee, Sangderk; Satish, Diksha; Devanney, Nicholas A; Cohen, Sarah; Morganti, Josh M; Gordon, Scott M; Johnson, Lance A

Knockout of Perilipin-2 in Microglia Alters Lipid Droplet Accumulation and Response to Alzheimer's Disease Stimuli

敲除小胶质细胞中的Perilipin-2会改变脂滴的积累和对阿尔茨海默病刺激的反应

Stephens, Isaiah O; Johnson, Lance A

APOE-Targeted Therapeutics for Alzheimer's Disease

针对阿尔茨海默病的APOE靶向疗法

Yassine, Hussein N; Hugo, Cristelle; O'Donovan, Bernadette; Stephens, Isaiah O; Johnson, Lance A; Cole, Gregory; Tcw, Julia; Johansson, Jan; Kisler, Kassandra; Chiba-Falek, Ornit

Prevalence and Correlates of Clinical Nephropathy in Patients With Type 2 Diabetes at Abia State Specialist Hospital and Diagnostic Center, Umuahia, Nigeria: A Cross-Sectional Study

尼日利亚阿比亚州乌穆阿希亚专科医院和诊断中心2型糖尿病患者临床肾病患病率及相关因素:一项横断面研究

Okeji, Izuchukwu E; Uzor, Onyedikachi F; Okafor, Christopher C; Okafor, Silas U; Airaodion, Augustine I; Orji, Obinna J; Abali, Isaiah O; Esangbedo, Ikpembhosa J; Jolaoye, Oladoyin Ogunbayo; Olaotan, Temitayo O; Zacs, Innocent Chima; Umeh, Akudo B; Ojumonu, Ugonna Emmanuella; Ekwere, Abasiekeme Monday; Madueke, Cynthia Kenechukwu; Austin-Jemifor, Ochuko; Victor-Anozie, Excel Nwasinachi; Amuta, Augustine C; Umeh, Chibuike

High-Resolution Spatial Profiling of Microglia Reveals Proximity Associated Immunometabolic Reprogramming in Alzheimer's Disease

高分辨率空间分析揭示小胶质细胞在阿尔茨海默病中与邻近性相关的免疫代谢重编程

Saito, Kai; Goulding, Danielle S; Nolt, Georgia L; Dimas, Sophia H; Moore, Lauren C; Stevens, Isaiah O; Anderson, Sonya; Snipes, Andy; Macauley, Shannon L; Nelson, Peter T; Johnson, Lance A; Morganti, Josh M

Inhibition of a Microbiota-Derived Peptide Ameliorates Established Acute Lung Injury

抑制微生物衍生肽可改善已发生的急性肺损伤

Valeria Fridman D'Alessandro, Corina N D'Alessandro-Gabazza, Taro Yasuma, Masaaki Toda, Atsuro Takeshita, Atsushi Tomaru, Suphachai Tharavecharak, Isaiah O Lasisi, Rebecca Y Hess, Kota Nishihama, Hajime Fujimoto, Tetsu Kobayashi, Isaac Cann, Esteban C Gabazza

COVID‐19 and Alzheimer’s disease: Meninges‐mediated neuropathology

COVID-19 与阿尔茨海默病:脑膜介导的神经病理学

Sihvonen, Aleksi J; Siponkoski, Sini-Tuuli; Martínez-Molina, Noelia; Laitinen, Sari; Holma, Milla; Ahlfors, Mirja; Kuusela, Linda; Pekkola, Johanna; Koskinen, Sanna; Särkämö, Teppo; Dehkordi, Shiva Kazempour; Orr, Timothy C; Bodamer, Ryan H; Hudson, Hannah R; Sun, Victoria; Keene, C Dirk; Zare, Habil; Orr, Miranda E; Golden, Lesley R; Stephens, Isaiah O; Siano, Dahlia; MacLean, Steven M; Pandya, Kumar; Gordon, Scott; Morganti, Josh M; Johnson, Lance A; Raval, Urdhva; Trageser, Kyle J; Naughton, Sean X; Griggs, Elizabeth; Iqbal, Umar Haris; Wu, Henry; Rahim, Md Al; Harary, Joyce M; Gursahai, Susan; Pasinetti, Giulio Maria