日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Activation of a Bacterial Mechanosensitive Channel, MscL, Underlies the Membrane Permeabilization of Dual-Targeting Antibacterial Compounds

细菌机械敏感通道 MscL 的激活是双靶向抗菌化合物膜通透性的基础

Robin Wray, Junmei Wang, Paul Blount, Irene Iscla

In Silico Screen Identifies a New Family of Agonists for the Bacterial Mechanosensitive Channel MscL

通过计算机筛选鉴定出细菌机械敏感通道 MscL 的新型激动剂家族

Robin Wray, Paul Blount, Junmei Wang, Irene Iscla

Curcumin activation of a bacterial mechanosensitive channel underlies its membrane permeability and adjuvant properties

姜黄素激活细菌机械敏感通道是其膜通透性和佐剂特性的基础。

Wray, Robin; Iscla, Irene; Blount, Paul

Novel compounds that specifically bind and modulate MscL: insights into channel gating mechanisms

新型化合物能够特异性结合并调节MscL:揭示通道门控机制

Wray, Robin; Iscla, Irene; Kovacs, Zoltan; Wang, Junmei; Blount, Paul

An agonist of the MscL channel affects multiple bacterial species and increases membrane permeability and potency of common antibiotics

MscL通道激动剂可影响多种细菌,并增加细胞膜通透性和常用抗生素的效力。

Wray, Robin; Herrera, Nadia; Iscla, Irene; Wang, Junmei; Blount, Paul

Dihydrostreptomycin Directly Binds to, Modulates, and Passes through the MscL Channel Pore

二氢链霉素直接结合、调节并穿过MscL通道孔

Wray, Robin; Iscla, Irene; Gao, Ya; Li, Hua; Wang, Junmei; Blount, Paul

Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance

小电导阴离子选择性机械敏感通道的结构和分子机制

Zhang, Xiaozhe; Wang, Jingjing; Feng, Yue; Ge, Jingpeng; Li, Wenfei; Sun, Wending; Iscla, Irene; Yu, Jie; Blount, Paul; Li, Yang; Yang, Maojun

Sensing and responding to membrane tension: the bacterial MscL channel as a model system

感知和响应膜张力:以细菌 MscL 通道为模型系统

Iscla, Irene; Blount, Paul

An in vivo screen reveals protein-lipid interactions crucial for gating a mechanosensitive channel

体内筛选揭示了对机械敏感通道门控至关重要的蛋白质-脂质相互作用

Iscla, Irene; Wray, Robin; Blount, Paul