日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

AAV-mediated inner ear gene delivery triggers mild host immune responses in the mammalian inner ear.

AAV介导的内耳基因递送可引发哺乳动物内耳中轻微的宿主免疫反应

Ishibashi Yasuko, Zhu Jianliang, Gernoux Gwladys, Yu Yunkai, Suh Michelle J, Isgrig Kevin, Grati Mhamed, Olszewski Rafal, Hoa Michael, Liang Cao, Friedman Thomas B, Adjali Oumeya, Chien Wade W

SLC26A4-AP-2 mu2 interaction regulates SLC26A4 plasma membrane abundance in the endolymphatic sac

SLC26A4-AP-2 mu2 相互作用调节内淋巴囊中的 SLC26A4 质膜丰度

Hyun Jae Lee, Cristina Fenollar-Ferrer, Kevin Isgrig, Ya-Xian Wang, Kerstin Valente, Juleh Eide, Keiji Honda, Wade W Chien, Ronald S Petralia, Lijin Dong, Thomas B Friedman, Juan S Bonifacino, Andrew J Griffith, Isabelle Roux

Early-Onset Hearing Loss in Mouse Models of Alzheimer's Disease and Increased DNA Damage in the Cochlea

阿尔茨海默病小鼠模型中早发性听力损失和耳蜗 DNA 损伤增加

Jae-Hyeon Park, Burcin Duan Sahbaz, Komal Pekhale, Xixia Chu, Mustafa N Okur, Mhamed Grati, Kevin Isgrig, Wade Chien, Elena Chrysostomou, Lauren Sullivan, Deborah L Croteau, Uri Manor, Vilhelm A Bohr

Combined AAV-mediated gene replacement therapy improves auditory function in a mouse model of human DFNB42 deafness

联合AAV介导的基因替代疗法可改善人类DFNB42耳聋小鼠模型的听觉功能

Isgrig, Kevin; Cartagena-Rivera, Alexander X; Wang, Hong Jun; Grati, Mhamed; Fernandez, Katharine A; Friedman, Thomas B; Belyantseva, Inna A; Chien, Wade

Dual-AAV vector-mediated expression of MYO7A improves vestibular function in a mouse model of Usher syndrome 1B

双 AAV 载体介导的 MYO7A 表达可改善 Usher 综合征 1B 小鼠模型的前庭功能

Samantha C Lau, Mhamed Grati, Kevin Isgrig, Moaz Sinan, Kaitlyn R Calabro, Jianliang Zhu, Yasuko Ishibashi, Zeynep Ozgur, Talah Wafa, Inna A Belyantseva, Tracy Fitzgerald, Thomas B Friedman, Sanford L Boye, Shannon E Boye, Wade W Chien

Gene Therapy Restores Balance and Auditory Functions in a Mouse Model of Usher Syndrome

基因疗法恢复了 Usher 综合征小鼠模型的平衡和听觉功能

Isgrig, Kevin; Shteamer, Jack W; Belyantseva, Inna A; Drummond, Meghan C; Fitzgerald, Tracy S; Vijayakumar, Sarath; Jones, Sherri M; Griffith, Andrew J; Friedman, Thomas B; Cunningham, Lisa L; Chien, Wade W

AAV8BP2 and AAV8 transduce the mammalian cochlear lateral wall and endolymphatic sac with high efficiency

AAV8BP2 和 AAV8 高效传导哺乳动物耳蜗侧壁和内淋巴囊

Kevin Isgrig, Yasuko Ishibashi, Hyun Jae Lee, Jianliang Zhu, Mhamed Grati, Jean Bennett, Andrew J Griffith, Isabelle Roux, Wade W Chien

Refining surgical techniques for efficient posterior semicircular canal gene delivery in the adult mammalian inner ear with minimal hearing loss

改进手术技术,在成年哺乳动物内耳中有效传递后半规管基因,同时最大程度减少听力损失

Jianliang Zhu #, Jin Woong Choi #, Yasuko Ishibashi, Kevin Isgrig, Mhamed Grati, Jean Bennett, Wade Chien

AAV2.7m8 is a powerful viral vector for inner ear gene therapy

AAV2.7m8 是一种用于内耳基因治疗的强大病毒载体

Kevin Isgrig, Devin S McDougald, Jianliang Zhu, Hong Jun Wang, Jean Bennett, Wade W Chien

Surgical Methods for Inner Ear Gene Delivery in Neonatal Mouse

新生小鼠内耳基因导入的外科手术方法

Isgrig, Kevin; Chien, Wade W