日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

A Pathogenic ROCK-Signaling Network Involving a Lysine Deletion in Myh11 Renders Carriers Susceptible to Aortic Dissection

涉及 Myh11 基因赖氨酸缺失的致病性 ROCK 信号通路网络使携带者易患主动脉夹层

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms27073195
Okuhata, Hironori; Tomida, Shota; Ishima, Tamaki; Nagai, Ryozo; Aizawa, Kenichi
信号转导
ROCK
发表日期：2026
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Targeting the undruggable transcription factor, KLF5, with a peptidomimetic small molecule, NC114, attenuates pressure overload-induced cardiac remodeling and fibrosis.

利用肽模拟小分子 NC114 靶向不可成药的转录因子 KLF5，可减轻压力超负荷引起的心脏重塑和纤维化。

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-025-32155-y
Methatham Thanachai, Kimura Natsuka, Tomida Shota, Ishima Tamaki, Taguchi Yuki, Uosaki Hideki, Sakashita Eiji, Endo Hitoshi, Nagai Ryozo, Aizawa Kenichi
心血管
KLF5
发表日期：2026
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Exhaled Breath Analysis for Head and Neck Cancer Using Fourier-Transform Infrared Spectroscopy: A Feasibility Study for Non-Invasive Screening

利用傅里叶变换红外光谱法进行呼出气体分析以筛查头颈癌：一项非侵入性筛查的可行性研究

期刊:Diagnostics
影响因子:3.3
doi:10.3390/diagnostics16030477
Nakasuji, Kota; Tanaka, Yoshihito; Yamamoto, Masato; Honda, Hidehiko; Kobayashi, Hirokazu; Shimane, Toshikazu; Kobayashi, Hitome; Murayama, Masakazu; Ishima, Takahiro
肿瘤
肿瘤免疫
头颈癌
发表日期：2026
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Structures of TGF-β with betaglycan and signaling receptors reveal mechanisms of complex assembly and signaling

TGF-β 与 β-聚糖和信号受体的结构揭示了复合物组装和信号传导的机制

期刊:Nature Communications
影响因子:14.7
doi:10.1038/s41467-025-56796-9.
Łukasz Wieteska,Alexander B Taylor,Emma Punch,Jonathan A Coleman,Isabella O Conway,Yeu-Farn Lin,Chang-Hyeock Byeon,Cynthia S Hinck,Troy Krzysiak,Rieko Ishima,Fernando López-Casillas,Peter Cherepanov,Daniel J Bernard,Caroline S Hill,Andrew P Hinck
信号转导
TGF-β
发表日期：2025
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A Highly Potent Apomorphine Derivative Enhancing Neurite Outgrowth via Nrf2 Activation

一种通过激活Nrf2增强神经突生长的高效阿扑吗啡衍生物

期刊:Antioxidants
影响因子:6.6
doi:10.3390/antiox14050537
Ishima, Tamaki; Osaka, Hitoshi; Nagai, Ryozo; Aizawa, Kenichi
发表日期：2025
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Whole Blood Metabolomic Profiling of Mice with Tacrolimus-Induced Chronic Nephrotoxicity: NAD(+) Depletion with Salvage Pathway Impairment

他克莫司诱导慢性肾毒性小鼠的全血代谢组学分析：NAD(+)耗竭伴补救途径受损

期刊:Antioxidants
影响因子:6.6
doi:10.3390/antiox14010062
Nishida, Sho; Ishima, Tamaki; Iwami, Daiki; Nagai, Ryozo; Aizawa, Kenichi
代谢
毒理研究
发表日期：2025
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Loss of Myh11 K1256 Dysregulates the Extracellular Matrix and Focal Adhesion by Inhibiting Zyxin-Activated Transcription

Myh11 K1256 的缺失通过抑制 Zyxin 激活的转录而导致细胞外基质和黏着斑的失调

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms26167853
Tomida, Shota; Okuhata, Hironori; Ishima, Tamaki; Nagai, Ryozo; Aizawa, Kenichi
细胞生物学
发表日期：2025
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Trans-Omic Analysis Identifies the 'PRMT1-STAT3-Integrin αVβ6 Axis' as a Novel Therapeutic Target in Tacrolimus-Induced Chronic Nephrotoxicity

跨组学分析发现“PRMT1-STAT3-整合素αVβ6轴”是治疗他克莫司诱导的慢性肾毒性的新型治疗靶点

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms262110282
Nishida, Sho; Ishima, Tamaki; Iwami, Daiki; Nagai, Ryozo; Aizawa, Kenichi
JAK/STAT
STAT3
毒理研究
PRMT1
发表日期：2025
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DHA-Triacylglycerol Accumulation in Tacrolimus-Induced Nephrotoxicity Identified by Lipidomic Profiling

脂质组学分析鉴定出他克莫司诱导肾毒性中DHA-三酰甘油的积累

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms26157549
Nishida, Sho; Ishima, Tamaki; Iwami, Daiki; Nagai, Ryozo; Aizawa, Kenichi
毒理研究
发表日期：2025
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An SH3-binding allosteric modulator stabilizes the global conformation of the AML-associated Src-family kinase, Hck

SH3结合变构调节剂可稳定AML相关Src家族激酶Hck的整体构象。

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2024.108088
Selzer, Ari M; Gerlach, Gabriella; Gonzalez-Areizaga, Giancarlo; Wales, Thomas E; Cui, Stephanie Y; Iyer, Prema; Engen, John R; Camacho, Carlos; Ishima, Rieko; Smithgall, Thomas E
信号转导
发表日期：2025
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