日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Colonic biopsy-associated microbial signatures are predictive of response to anti-TNFα biological therapy in Crohn's disease

结肠活检相关的微生物特征可预测克罗恩病患者对TNFα抑制剂生物疗法的反应

期刊:Frontiers in Cellular and Infection Microbiology
影响因子:4.8
doi:10.3389/fcimb.2026.1741002
Zafeiropoulou, Konstantina; Hageman, Ishtu L; Mu, Tianqi; Davids, Mark; Li Yim, Andrew Y F; Joustra, Vincent W; Hakvoort, Theodorus B M; Satsangi, Jack; Chronas, Konstantinos; Koelink, Pim J; Wildenberg, Manon E; van den Wijngaard, Rene M; D'Haens, Geert R; de Jonge, Wouter J
微生物学
克罗恩病
TNFα
发表日期：2026
文献求助 收藏

An exploratory single-cell analysis of peripheral blood mononuclear cells from vedolizumab-treated Crohn's disease patients identifies response-associated differences among the plasmacytoid dendritic cells and classical monocytes

对接受维多珠单抗治疗的克罗恩病患者外周血单核细胞进行探索性单细胞分析，发现浆细胞样树突状细胞和经典单核细胞之间存在与治疗反应相关的差异。

期刊:Frontiers in Immunology
影响因子:5.9
doi:10.3389/fimmu.2025.1551017
Li Yim, Andrew Yung Fong; Hageman, Ishtu; Joustra, Vincent W; Elfiky, Ahmed M I M; Ghiboub, Mohammed; Levin, Evgeni; Verhoeff, Jan; Verseijden, Caroline; Admiraal, Iris; de Krijger, Manon; Wildenberg, Manon E; Mannens, Marcel; Jakobs, Marja E; Kenter, Susan B; Adams, Alex T; Satsangi, Jack; D'Haens, Geert R; de Jonge, Wouter J; Henneman, Peter
单细胞
树突状细胞
单核细胞
细胞生物学
克罗恩病
树突状细胞
免疫/内分泌
发表日期：2025
文献求助 收藏

Peripheral Blood DNA Methylation Signatures and Response to Tofacitinib in Moderate-to-severe Ulcerative Colitis

中重度溃疡性结肠炎患者外周血DNA甲基化特征与托法替尼治疗反应的关系

期刊:Journal of Crohns & Colitis
影响因子:8.7
doi:10.1093/ecco-jcc/jjad129
Joustra, Vincent; Li Yim, Andrew Y F; van Gennep, Sara; Hageman, Ishtu; de Waard, Tristan; Levin, Evgeni; Lauffer, Peter; de Jonge, Wouter; Henneman, Peter; Löwenberg, Mark; D'Haens, Geert
肠炎
表观遗传
DNA甲基化
DNA甲基化
结肠炎
发表日期：2024
文献求助 收藏

Systematic Review and Meta-analysis of Peripheral Blood DNA Methylation Studies in Inflammatory Bowel Disease

炎症性肠病外周血DNA甲基化研究的系统评价和荟萃分析

期刊:Journal of Crohns & Colitis
影响因子:8.7
doi:10.1093/ecco-jcc/jjac119
Joustra, Vincent; Hageman, Ishtu L; Satsangi, Jack; Adams, Alex; Ventham, Nicholas T; de Jonge, Wouter J; Henneman, Peter; D'Haens, Geert R; Li Yim, Andrew Y F
炎症
表观遗传
DNA甲基化
炎症/感染
DNA甲基化
发表日期：2023
文献求助 收藏

Long-term Temporal Stability of Peripheral Blood DNA Methylation Profiles in Patients With Inflammatory Bowel Disease

炎症性肠病患者外周血DNA甲基化谱的长期时间稳定性

期刊:Cellular and Molecular Gastroenterology and Hepatology
影响因子:7.4
doi:10.1016/j.jcmgh.2022.12.011
Joustra, Vincent; Li Yim, Andrew Y F; Hageman, Ishtu; Levin, Evgeni; Adams, Alex; Satsangi, Jack; de Jonge, Wouter J; Henneman, Peter; D'Haens, Geert
DNA甲基化
发表日期：2023
文献求助 收藏

Novel DNA methylome biomarkers associated with adalimumab response in rheumatoid arthritis patients

与类风湿性关节炎患者阿达木单抗疗效相关的新型DNA甲基化组生物标志物

期刊:Frontiers in Immunology
影响因子:5.9
doi:10.3389/fimmu.2023.1303231
Hageman, Ishtu; Mol, Femke; Atiqi, Sadaf; Joustra, Vincent; Sengul, Hilal; Henneman, Peter; Visman, Ingrid; Hakvoort, Theodorus; Nurmohamed, Mike; Wolbink, Gertjan; Levin, Evgeni; Li Yim, Andrew Y F; D'Haens, Geert; de Jonge, Wouter J
关节炎
表观遗传
DNA甲基化
发表日期：2023
文献求助 收藏

Carboxylesterase-1 Assisted Targeting of HDAC Inhibitors to Mononuclear Myeloid Cells in Inflammatory Bowel Disease

羧酸酯酶-1辅助HDAC抑制剂靶向炎症性肠病中的单核髓系细胞

期刊:Journal of Crohns & Colitis
影响因子:8.7
doi:10.1093/ecco-jcc/jjab176
Elfiky, Ahmed M I; Ghiboub, Mohammed; Li Yim, Andrew Y F; Hageman, Ishtu L; Verhoeff, Jan; de Krijger, Manon; van Hamersveld, Patricia H P; Welting, Olaf; Admiraal, Iris; Rahman, Shafaque; Garcia-Vallejo, Juan J; Wildenberg, Manon E; Tomlinson, Laura; Gregory, Richard; Rioja, Inmaculada; Prinjha, Rab K; Furze, Rebecca C; Lewis, Huw D; Mander, Palwinder K; Heinsbroek, Sigrid E M; Bell, Matthew J; de Jonge, Wouter J
炎症/感染
细胞生物学
炎症
发表日期：2022
文献求助 收藏

Epigenetic Signatures Discriminate Patients With Primary Sclerosing Cholangitis and Ulcerative Colitis From Patients With Ulcerative Colitis

表观遗传特征可将原发性硬化性胆管炎和溃疡性结肠炎患者与溃疡性结肠炎患者区分开来

期刊:Frontiers in Immunology
影响因子:5.7
doi:10.3389/fimmu.2022.840935
Manon de Krijger, Ishtu L Hageman, Andrew Y F Li Yim, Jan Verhoeff, Juan J Garcia Vallejo, Patricia H P van Hamersveld, Evgeni Levin, Theodorus B M Hakvoort, Manon E Wildenberg, Peter Henneman, Cyriel Y Ponsioen, Wouter J de Jonge
表观遗传
肠炎
发表日期：2022
文献求助 收藏

A BET Protein Inhibitor Targeting Mononuclear Myeloid Cells Affects Specific Inflammatory Mediators and Pathways in Crohn's Disease

一种靶向单核髓系细胞的BET蛋白抑制剂可影响克罗恩病中的特定炎症介质和通路

期刊:Cells
影响因子:5.2
doi:10.3390/cells11182846
Elfiky, Ahmed M I; Hageman, Ishtu L; Becker, Marte A J; Verhoeff, Jan; Li Yim, Andrew Y F; Joustra, Vincent W; Mulders, Lieven; Fung, Ivan; Rioja, Inmaculada; Prinjha, Rab K; Smithers, Nicholas N; Furze, Rebecca C; Mander, Palwinder K; Bell, Matthew J; Buskens, Christianne J; D'Haens, Geert R; Wildenberg, Manon E; de Jonge, Wouter J
炎症
炎症/感染
信号转导
细胞生物学
克罗恩病
发表日期：2022
文献求助 收藏

Peripheral Blood DNA Methylation Profiles Do Not Predict Endoscopic Post-Operative Recurrence in Crohn's Disease Patients

外周血DNA甲基化谱不能预测克罗恩病患者术后内镜复发

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms231810467
Joustra, Vincent W; Li Yim, Andrew Y F; de Bruyn, Jessica R; Duijvestein, Marjolijn; Hageman, Ishtu L; de Jonge, Wouter J; Henneman, Peter; Wildenberg, Manon; D'Haens, Geert
DNA甲基化
克罗恩病
表观遗传
DNA甲基化
发表日期：2022
文献求助 收藏