日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The metabolic dysfunction-associated steatohepatitis (MASH) drug resmetirom exhibits broad nuclear receptor activity with minimal functional impact

代谢功能障碍相关性脂肪性肝炎(MASH)药物瑞斯美替罗具有广泛的核受体活性,但对功能的影响极小。

Kärcher, Annette; Isigkeit, Laura; Bandomir, Nils Christiaan; Schubert-Zsilavecz, Manfred; Heitel, Pascal

Chemogenomics for steroid hormone receptors (NR3)

类固醇激素受体(NR3)化学基因组学

Espen Schallmayer, Laura Isigkeit, Lewis Elson, Susanne Müller, Stefan Knapp, Julian A Marschner, Daniel Merk

Fatty Acid Mimetic Fragments as Liver Receptor Homologue-1 Modulators

脂肪酸模拟片段作为肝脏受体同源物-1调节剂

Lang, Alisa; Stiller, Tanja; Ildefeld, Niklas; Heitel, Pascal; Isigkeit, Laura; Proschak, Ewgenij; Heering, Jan; Schubert-Zsilavecz, Manfred; Merk, Daniel

Toward target 2035: EUbOPEN - a public-private partnership to enable & unlock biology in the open

迈向2035年目标:EUbOPEN——一项旨在促进和开放生物学的公私合作项目

Tredup, Claudia; Ackloo, Suzanne; Beck, Hartmut; Brown, Peter J; Bullock, Alex N; Ciulli, Alessio; Dikic, Ivan; Edfeldt, Kristina; Edwards, Aled M; Elkins, Jonathan M; Farin, Henner F; Fon, Edward A; Gstaiger, Matthias; Günther, Judith; Gustavsson, Anna-Lena; Häberle, Sandra; Isigkeit, Laura; Huber, Kilian V M; Kotschy, Andras; Krämer, Oliver; Leach, Andrew R; Marsden, Brian D; Matsui, Hisanori; Merk, Daniel; Montel, Florian; Mulder, Monique P C; Müller, Susanne; Owen, Dafydd R; Proschak, Ewgenij; Röhm, Sandra; Stolz, Alexandra; Sundström, Michael; von Delft, Frank; Willson, Timothy M; Arrowsmith, Cheryl H; Knapp, Stefan

Automated design of multi-target ligands by generative deep learning

通过生成深度学习自动设计多靶点配体

Laura Isigkeit, Tim Hörmann, Espen Schallmayer, Katharina Scholz, Felix F Lillich, Johanna H M Ehrler, Benedikt Hufnagel, Jasmin Büchner, Julian A Marschner, Jörg Pabel, Ewgenij Proschak, Daniel Merk

Chemogenomics for NR1 nuclear hormone receptors

NR1 核激素受体化学基因组学

Laura Isigkeit #, Espen Schallmayer #, Romy Busch, Lorene Brunello, Amelie Menge, Lewis Elson, Susanne Müller, Stefan Knapp, Alexandra Stolz, Julian A Marschner, Daniel Merk

Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPARγ Modulation

靶向替代维生素E代谢物结合位点可实现非经典PPARγ调节

Arifi, Silvia; Marschner, Julian A; Pollinger, Julius; Isigkeit, Laura; Heitel, Pascal; Kaiser, Astrid; Obeser, Lennart; Höfner, Georg; Proschak, Ewgenij; Knapp, Stefan; Chaikuad, Apirat; Heering, Jan; Merk, Daniel

Activity Screening of Fatty Acid Mimetic Drugs Identified Nuclear Receptor Agonists

脂肪酸模拟药物活性筛选鉴定出核受体激动剂

Helmstädter, Moritz; Schierle, Simone; Isigkeit, Laura; Proschak, Ewgenij; Marschner, Julian Aurelio; Merk, Daniel

Inter-individual differences in cytokine release in patients undergoing cardiac surgery with cardiopulmonary bypass.

接受体外循环心脏手术的患者细胞因子释放的个体差异

Roth-Isigkeit A, Hasselbach L, Ocklitz E, Brückner S, Ros A, Gehring H, Schmucker P, Rink L, Seyfarth M

Perioperative serum levels of tumour-necrosis-factor alpha (TNF-alpha), IL-1 beta, IL-6, IL-10 and soluble IL-2 receptor in patients undergoing cardiac surgery with cardiopulmonary bypass without and with correction for haemodilution

围手术期接受体外循环心脏手术患者血清中肿瘤坏死因子α (TNF-α)、IL-1β、IL-6、IL-10 和可溶性IL-2受体的水平,分别在未校正和校正血液稀释的情况下进行测定。

Roth-Isigkeit, A; Borstel, T V; Seyfarth, M; Schmucker, P