日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors

针对晚期难治性实体瘤患者的靶向PD-L1和4-1BB的双特异性抗体(GEN1046)的临床前特征和I期试验结果

Alexander Muik,Elena Garralda,Isil Altintas,Friederike Gieseke,Ravit Geva,Eytan Ben-Ami,Corinne Maurice-Dror,Emiliano Calvo,Patricia M LoRusso,Guzman Alonso,Maria E Rodriguez-Ruiz,Kristina B Schoedel,Jordan M Blum,Bianca Sänger,Theodora W Salcedo,Saskia M Burm,Eliana Stanganello,Dennis Verzijl,Fulvia Vascotto,Angelica Sette,Juliane Quinkhardt,Theo S Plantinga,Aras Toker,Edward N van den Brink,Mark Fereshteh,Mustafa Diken,David Satijn,Sebastian Kreiter,Esther C W Breij,Gaurav Bajaj,Eleni Lagkadinou,Kate Sasser,Özlem Türeci,Ulf Forssmann,Tahamtan Ahmadi,Uğur Şahin #,Maria Jure-Kunkel #,Ignacio Melero #

DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity

DuoBody-CD40x4-1BB 通过条件性 CD40 和 4-1BB 激动剂活性诱导树突状细胞成熟并增强 T 细胞活化。

Alexander Muik ,Homer C Adams 3rd ,Friederike Gieseke ,Isil Altintas ,Kristina B Schoedel ,Jordan M Blum ,Bianca Sänger ,Saskia M Burm ,Eliana Stanganello ,Dennis Verzijl ,Vanessa M Spires ,Fulvia Vascotto ,Aras Toker ,Juliane Quinkhardt ,Mark Fereshteh ,Mustafa Diken ,David P E Satijn ,Sebastian Kreiter ,Tahamtan Ahmadi ,Esther C W Breij ,Özlem Türeci ,Kate Sasser ,Ugur Sahin ,Maria Jure-Kunkel

An Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulation

Fc 惰性 PD-L1×4-1BB 双特异性抗体通过结合检查点抑制和条件性 4-1BB 共刺激在小鼠中介导强大的抗肿瘤免疫

Alexander Muik, Isil Altintas, Friederike Gieseke, Kristina B Schoedel, Saskia M Burm, Aras Toker, Theodora W Salcedo, Dennis Verzijl, David Eisel, Christian Grunwitz, Lena M Kranz, Mathias Vormehr, David P E Satijn, Mustafa Diken, Sebastian Kreiter, Kate Sasser, Tahamtan Ahmadi, Özlem Türeci, Esthe

Targeting hepatocyte growth factor receptor (Met) positive tumor cells using internalizing nanobody-decorated albumin nanoparticles

使用内化纳米抗体修饰的白蛋白纳米粒子靶向肝细胞生长因子受体 (Met) 阳性肿瘤细胞

Raimond Heukers, Isil Altintas, Smiriti Raghoenath, Erica De Zan, Richard Pepermans, Rob C Roovers, Rob Haselberg, Wim E Hennink, Raymond M Schiffelers, Robbert J Kok, Paul M P van Bergen en Henegouwen