日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Plasmodium falciparum Niemann-Pick Type C1-Related protein relies on its physicochemical properties for membrane contact site localization required for cholesterol homeostasis

恶性疟原虫尼曼-匹克C1型相关蛋白依靠其理化性质进行膜接触位点定位,这对于胆固醇稳态至关重要。

Ray, Ananya; Istvan, Eva S; Goldberg, Daniel E; Garten, Matthias

Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining

利用预测结构和数据挖掘技术重新审视恶性疟原虫可药物靶向基因组

Godinez-Macias, Karla P; Chen, Daisy; Wallis, J Lincoln; Siegel, Miles G; Adam, Anna; Bopp, Selina; Carolino, Krypton; Coulson, Lauren B; Durst, Greg; Thathy, Vandana; Esherick, Lisl; Farringer, Madeline A; Flannery, Erika L; Forte, Barbara; Liu, Tiqing; Godoy Magalhaes, Luma; Gupta, Anil K; Istvan, Eva S; Jiang, Tiantian; Kumpornsin, Krittikorn; Lobb, Karen; McLean, Kyle J; Moura, Igor M R; Okombo, John; Payne, N Connor; Plater, Andrew; Rao, Srinivasa P S; Siqueira-Neto, Jair L; Somsen, Bente A; Summers, Robert L; Zhang, Rumin; Gilson, Michael K; Gamo, Francisco-Javier; Campo, Brice; Baragaña, Beatriz; Duffy, James; Gilbert, Ian H; Lukens, Amanda K; Dechering, Koen J; Niles, Jacquin C; McNamara, Case W; Cheng, Xiu; Birkholtz, Lyn-Marie; Bronkhorst, Alfred W; Fidock, David A; Wirth, Dyann F; Goldberg, Daniel E; Lee, Marcus C S; Winzeler, Elizabeth A

Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance.

恶性疟原虫体外系统进化揭示了耐药性的关键决定因素

Luth Madeline R, Godinez-Macias Karla P, Chen Daisy, Okombo John, Thathy Vandana, Cheng Xiu, Daggupati Sindhu, Davies Heledd, Dhingra Satish K, Economy Jan M, Edgar Rebecca C S, Gomez-Lorenzo Maria G, Istvan Eva S, Jado Juan Carlos, LaMonte Gregory M, Melillo Bruno, Mok Sachel, Narwal Sunil K, Ndiaye Tolla, Ottilie Sabine, Palomo Diaz Sara, Park Heekuk, Peña Stella, Rocamora Frances, Sakata-Kato Tomoyo, Small-Saunders Jennifer L, Summers Robert L, Tumwebaze Patrick K, Vanaerschot Manu, Xia Guoqin, Yeo Tomas, You Ashley, Gamo Francisco-Javier, Goldberg Daniel E, Lee Marcus C S, McNamara Case W, Ndiaye Daouda, Rosenthal Philip J, Schreiber Stuart L, Serra Gloria, De Siqueira-Neto Jair Lage, Skinner-Adams Tina S, Uhlemann Anne-Catrin, Kato Nobutaka, Lukens Amanda K, Wirth Dyann F, Fidock David A, Winzeler Elizabeth A

The Plasmodium falciparum NCR1 transporter is an antimalarial target that exports cholesterol from the parasite's plasma membrane.

恶性疟原虫 NCR1 转运蛋白是一种抗疟靶点,可将胆固醇从寄生虫的质膜中输出

Zhang Zhemin, Lyu Meinan, Han Xu, Bandara Sepalika, Cui Meng, Istvan Eva S, Geng Xinran, Tringides Marios L, Gregor William D, Miyagi Masaru, Oberstaller Jenna, Adams John H, Zhang Youwei, Nieman Marvin T, von Lintig Johannes, Goldberg Daniel E, Yu Edward W

Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase

恶性疟原虫天冬酰胺tRNA合成酶的反应劫持抑制

Xie, Stanley C; Wang, Yinuo; Morton, Craig J; Metcalfe, Riley D; Dogovski, Con; Pasaje, Charisse Flerida A; Dunn, Elyse; Luth, Madeline R; Kumpornsin, Krittikorn; Istvan, Eva S; Park, Joon Sung; Fairhurst, Kate J; Ketprasit, Nutpakal; Yeo, Tomas; Yildirim, Okan; Bhebhe, Mathamsanqa N; Klug, Dana M; Rutledge, Peter J; Godoy, Luiz C; Dey, Sumanta; De Souza, Mariana Laureano; Siqueira-Neto, Jair L; Du, Yawei; Puhalovich, Tanya; Amini, Mona; Shami, Gerry; Loesbanluechai, Duangkamon; Nie, Shuai; Williamson, Nicholas; Jana, Gouranga P; Maity, Bikash C; Thomson, Patrick; Foley, Thomas; Tan, Derek S; Niles, Jacquin C; Han, Byung Woo; Goldberg, Daniel E; Burrows, Jeremy; Fidock, David A; Lee, Marcus C S; Winzeler, Elizabeth A; Griffin, Michael D W; Todd, Matthew H; Tilley, Leann

MalDA, Accelerating Malaria Drug Discovery

MalDA,加速疟疾药物研发

Yang, Tuo; Ottilie, Sabine; Istvan, Eva S; Godinez-Macias, Karla P; Lukens, Amanda K; Baragaña, Beatriz; Campo, Brice; Walpole, Chris; Niles, Jacquin C; Chibale, Kelly; Dechering, Koen J; Llinás, Manuel; Lee, Marcus C S; Kato, Nobutaka; Wyllie, Susan; McNamara, Case W; Gamo, Francisco Javier; Burrows, Jeremy; Fidock, David A; Goldberg, Daniel E; Gilbert, Ian H; Wirth, Dyann F; Winzeler, Elizabeth A

Prioritization of Molecular Targets for Antimalarial Drug Discovery

抗疟药物研发中分子靶点的优先排序

Forte, Barbara; Ottilie, Sabine; Plater, Andrew; Campo, Brice; Dechering, Koen J; Gamo, Francisco Javier; Goldberg, Daniel E; Istvan, Eva S; Lee, Marcus; Lukens, Amanda K; McNamara, Case W; Niles, Jacquin C; Okombo, John; Pasaje, Charisse Flerida A; Siegel, Miles G; Wirth, Dyann; Wyllie, Susan; Fidock, David A; Baragaña, Beatriz; Winzeler, Elizabeth A; Gilbert, Ian H

Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery

结合阶段特异性和代谢组学分析推进抗疟药物研发

Murithi, James M; Owen, Edward S; Istvan, Eva S; Lee, Marcus C S; Ottilie, Sabine; Chibale, Kelly; Goldberg, Daniel E; Winzeler, Elizabeth A; Llinás, Manuel; Fidock, David A; Vanaerschot, Manu

Malaria parasite plasmepsins: More than just plain old degradative pepsins

疟原虫血浆蛋白酶:不仅仅是普通的降解性胃蛋白酶

Nasamu, Armiyaw S; Polino, Alexander J; Istvan, Eva S; Goldberg, Daniel E

Plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state

恶性疟原虫通过进入休眠状态来应对氨基酸匮乏。

Babbitt, Shalon E; Altenhofen, Lindsey; Cobbold, Simon A; Istvan, Eva S; Fennell, Clare; Doerig, Christian; Llinás, Manuel; Goldberg, Daniel E