日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Development of a targeted BioPROTAC degrader selective for misfolded SOD1

开发一种针对错误折叠的SOD1的靶向BioPROTAC降解剂

Chisholm, Christen G; Bartlett, Rachael; Brown, Mikayla L; Proctor, Emma-Jayne; Farrawell, Natalie E; Gorman, Jody; Delerue, Fabien; Ittner, Lars M; Vine-Perrow, Kara L; Ecroyd, Heath; Cashman, Neil R; Saunders, Darren N; McAlary, Luke; Lum, Jeremy S; Yerbury, Justin J

Long read sequencing reveals transgene concatemerization and vector sequences integration following AAV-driven electroporation of CRISPR RNP complexes in mouse zygotes

长读长测序揭示了在小鼠合子中通过AAV驱动的CRISPR RNP复合物电穿孔后,转基因串联化和载体序列整合的情况

Luqman, Muhammad W; Jenjaroenpun, Piroon; Spathos, Jessica; Shingte, Nikhil; Cummins, Mitchell; Nimsamer, Pattaraporn; Ittner, Lars M; Wongsurawat, Thidathip; Delerue, Fabien

Developmental differentiation of mouse inner ear neuron subpopulations resolved with a peripherin-promoter reporter within the Grm8 locus.

利用 Grm8 基因座内的外周蛋白启动子报告基因解析小鼠内耳神经元亚群的发育分化

Pearson Lily J, Pinyon Jeremy L, Cederholm Jennie M E, von Jonquieres Georg, Bartlett Florence, Vázquez-Campos Xabier, Delerue Fabien, Ittner Lars M, Housley Gary D

Design of peptide therapeutics as protein-protein interaction inhibitors to treat neurodegenerative diseases

设计肽类药物作为蛋白质-蛋白质相互作用抑制剂,用于治疗神经退行性疾病

Ariawan, Daryl; Thananthirige, Kanishka P M; El-Omar, Ali; van der Hoven, Julia; Genoud, Sian; Stefen, Holly; Fath, Thomas; van Eersel, Janet; Ittner, Lars M; Tietz, Ole

Peptides for trans-blood-brain barrier delivery

用于跨血脑屏障递送的肽

Blades, Reuben; Ittner, Lars M; Tietz, Ole

Correction to: Developmental delay and late onset HBSL pathology in hypomorphic Dars1(M256L) mice

更正:Dars1(M256L)低表达小鼠的发育迟缓和迟发性HBSL病理

Klugmann, Matthias; Kalotay, Elizabeth; Delerue, Fabien; Ittner, Lars M; Bongers, Andre; Yu, Josephine; Morris, Margaret J; Housley, Gary D; Fröhlich, Dominik

TDP-43 and Inflammation: Implications for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

TDP-43 与炎症:对肌萎缩侧索硬化症和额颞叶痴呆症的影响

Bright, Fiona; Chan, Gabriella; van Hummel, Annika; Ittner, Lars M; Ke, Yazi D

The Nature of Diamino Linker and Halogen Bonding Define Selectivity of Pyrrolopyrimidine-Based LIMK1 Inhibitors

二氨基连接基和卤键的性质决定了吡咯并嘧啶类LIMK1抑制剂的选择性

Ariawan, Daryl; Au, Carol; Paric, Esmeralda; Fath, Thomas; Ke, Yazi D; Kassiou, Michael; van Eersel, Janet; Ittner, Lars M

Recent Developments in TSPO PET Imaging as A Biomarker of Neuroinflammation in Neurodegenerative Disorders

TSPO PET成像作为神经退行性疾病神经炎症生物标志物的最新进展

Werry, Eryn L; Bright, Fiona M; Piguet, Olivier; Ittner, Lars M; Halliday, Glenda M; Hodges, John R; Kiernan, Matthew C; Loy, Clement T; Kril, Jillian J; Kassiou, Michael

Developmental Expression of Mutant PFN1 in Motor Neurons Impacts Neuronal Growth and Motor Performance of Young and Adult Mice

突变型PFN1在运动神经元中的发育表达影响幼鼠和成年小鼠的神经元生长和运动能力

Brettle, Merryn; Stefen, Holly; Djordjevic, Aleksandra; Fok, Sandra Y Y; Chan, Josephine W; van Hummel, Annika; van der Hoven, Julia; Przybyla, Magdalena; Volkerling, Alexander; Ke, Yazi D; Delerue, Fabien; Ittner, Lars M; Fath, Thomas