日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Japanese Subgroup Analyses from EMERGE and ENGAGE, Phase 3 Clinical Trials of Aducanumab in Patients with Early Alzheimer's Disease

来自 EMERGE 和 ENGAGE 两项针对早期阿尔茨海默病患者的 Aducanumab III 期临床试验的日本亚组分析

Toda, Y; Iwatsubo, T; Nakamura, Y; Matsuda, N; Miyata, M; Jin, M; Chen, T; Kuribayashi, K; Tian, Y; Hughes, R; Yamamoto, J; Muralidharan, K K; Rubel, C; Hutchison, R M; Budd Haeberlein, S

A Japanese Multicenter Study on PET and Other Biomarkers for Subjects with Potential Preclinical and Prodromal Alzheimer's Disease

一项针对具有潜在临床前期和前驱期阿尔茨海默病特征的受试者的PET和其他生物标志物的日本多中心研究

Senda, M; Ishii, K; Ito, K; Ikeuchi, T; Matsuda, H; Iwatsubo, T; Iwata, A; Ihara, R; Suzuki, K; Kasuga, K; Ikari, Y; Niimi, Y; Arai, H; Tamaoka, A; Arahata, Y; Itoh, Y; Tachibana, H; Ichimiya, Y; Washizuka, S; Odawara, T; Ishii, K; Ono, K; Yokota, T; Nakanishi, A; Matsubara, E; Mori, H; Shimada, H

Using Digital Tools to Advance Alzheimer's Drug Trials During a Pandemic: The EU/US CTAD Task Force

利用数字化工具在疫情期间推进阿尔茨海默病药物试验:欧盟/美国CTAD工作组

Kaye, J; Aisen, P; Amariglio, R; Au, R; Ballard, C; Carrillo, M; Fillit, H; Iwatsubo, T; Jimenez-Maggiora, G; Lovestone, S; Natanegara, F; Papp, K; Soto, M E; Weiner, M; Vellas, B

Peripheral Blood BRCA1 Methylation Positively Correlates with Major Alzheimer's Disease Risk Factors

外周血BRCA1甲基化与阿尔茨海默病主要风险因素呈正相关

Mano, T; Sato, K; Ikeuchi, T; Toda, T; Iwatsubo, T; Iwata, A

Tauroursodeoxycholic Acid Attenuates Diet-Induced and Age-Related Peripheral Endoplasmic Reticulum Stress and Cerebral Amyloid Pathology in a Mouse Model of Alzheimer's Disease.

牛磺熊去氧胆酸可减轻阿尔茨海默病小鼠模型中饮食诱导和年龄相关的外周内质网应激和脑淀粉样蛋白病理

Ochiai T, Nagayama T, Matsui K, Amano K, Sano T, Wakabayashi T, Iwatsubo T

Visual-statistical interpretation of (18)F-FDG-PET images for characteristic Alzheimer patterns in a multicenter study: inter-rater concordance and relationship to automated quantitative evaluation

在一项多中心研究中,对 (18)F-FDG-PET 图像进行视觉统计解释,以识别阿尔茨海默病特征性模式:观察者间一致性及其与自动定量评估的关系

Yamane, T; Ikari, Y; Nishio, T; Ishii, K; Ishii, K; Kato, T; Ito, K; Silverman, D H S; Senda, M; Asada, T; Arai, H; Sugishita, M; Iwatsubo, T

Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin.

用针对尼卡斯特林胞外结构域的单克隆抗体中和 α-分泌酶活性

Hayashi I, Takatori S, Urano Y, Miyake Y, Takagi J, Sakata-Yanagimoto M, Iwanari H, Osawa S, Morohashi Y, Li T, Wong P C, Chiba S, Kodama T, Hamakubo T, Tomita T, Iwatsubo T

Genetic associations between cathepsin D exon 2 C-->T polymorphism and Alzheimer's disease, and pathological correlations with genotype

组织蛋白酶D外显子2 C→T多态性与阿尔茨海默病之间的遗传关联,以及与基因型的病理相关性

Davidson, Y; Gibbons, L; Pritchard, A; Hardicre, J; Wren, J; Tian, J; Shi, J; Stopford, C; Julien, C; Thompson, J; Payton, A; Thaker, U; Hayes, A J; Iwatsubo, T; Pickering-Brown, S M; Pendleton, N; Horan, M A; Burns, A; Purandare, N; Lendon, C L; Neary, D; Snowden, J S; Mann, D M A

Is there a relation between APOE expression and brain amyloid load in Alzheimer's disease?

阿尔茨海默病中APOE表达与脑淀粉样蛋白负荷之间是否存在关联?

Lambert, J-C; Mann, D; Richard, F; Tian, J; Shi, J; Thaker, U; Merrot, S; Harris, J; Frigard, B; Iwatsubo, T; Lendon, C; Amouyel, P

Association study of Notch 4 polymorphisms with Alzheimer's disease

Notch 4 多态性与阿尔茨海默病关联性研究

Lambert, J-C; Mann, D; Harris, J; Araria-Goumidi, L; Chartier-Harlin, M-C; Cottel, D; Iwatsubo, T; Amouyel, P; Lendon, C