日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Effects of CT-388, a once-weekly signaling-biased dual GLP-1/GIP receptor agonist, on weight loss and glycemic control in preclinical models and participants with obesity

CT-388 是一种每周一次给药的信号传导偏向型双重 GLP-1/GIP 受体激动剂,本研究探讨了其对临床前模型和肥胖患者体重减轻和血糖控制的影响。

Chakravarthy, Manu V; Rodriguez, Ruben; Hergarden, Anne; Elliott, Michael A; Frias, Juan P; Argüelles-Tello, Federico A; Tenorio, Edgar; Rankin, Jonathan E; Wu, Jingtao; Krishnan, Shyam; Erlanson, Daniel A; Fucini, Raymond V; Bone, Derek; Iwig, Jeffrey S; Acosta, Luis; Untereiner, Ashley; Pant, Asmita; Patton, Avalon; Sanchez-Sanchez, Leyla L; Luo, Jian; Steinberg, Alexandra; Bialonczyk, Damian; Hansen, Stig K

Cryo-EM structures of photosystem I with alternative quinones reveals new insight into cofactor selectivity

利用冷冻电镜技术解析光系统I与替代醌类化合物的结构,揭示了辅因子选择性的新见解

Brininger, Christian M; Wang, Jimin; Kurashov, Vasily; Russell, Brandon P; Magdaong, Nikki Cecil M; Iwig, David F; van der Est, Art; Golbeck, John H; Vinyard, David J; Lakshmi, K V; Gisriel, Christopher J

Radical Fluoromethylation Enabled by Cobalamin-Dependent Radical SAM Enzymes

钴胺素依赖性自由基SAM酶介导的自由基氟甲基化

Neti, Syam Sundar; Wang, Bo; Cui, Jiayuan; Iwig, David F; York, Nicholas J; Blaszczyk, Anthony J; Bauerle, Matthew R; Booker, Squire J

A variant of the MenB strain of Synechocystis sp. PCC 6803 disrupts a stress response pathway allowing DMPBQ to occupy the A(1) sites of photosystem I

蓝藻集胞藻 PCC 6803 的 MenB 菌株变体破坏了应激反应通路,使 DMPBQ 能够占据光系统 I 的 A(1) 位点。

Russell, Brandon P; Kurashov, Vasily; Iwig, David F; Landry, Patrick; Johnson, Wade; van der Est, Art; Golbeck, John H; Vinyard, David J; Lakshmi, K V

Cryo-EM structure of a photosystem I variant containing an unusual plastoquinone derivative in its electron transfer chain

含有不寻常的质体醌衍生物的光系统 I 变体的冷冻电镜结构,该衍生物位于其电子传递链中

Gisriel, Christopher J; Kurashov, Vasily; Iwig, David F; Russell, Brandon P; Vinyard, David J; Brudvig, Gary W; Golbeck, John H; Lakshmi, K V

Enzymatic Fluoromethylation Enabled by the S-Adenosylmethionine Analog Te-Adenosyl-L-(fluoromethyl)homotellurocysteine

S-腺苷甲硫氨酸类似物 Te-腺苷-L-(氟甲基)高碲半胱氨酸促进的酶促氟甲基化

Neti, Syam Sundar; Wang, Bo; Iwig, David F; Onderko, Elizabeth L; Booker, Squire J

Discovery, structure and mechanism of a tetraether lipid synthase

四醚脂质合酶的发现、结构和机制

Cody T Lloyd, David F Iwig, Bo Wang, Matteo Cossu, William W Metcalf, Amie K Boal, Squire J Booker0

A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1

组氨酸 pH 传感器调节 Ras 特异性鸟嘌呤核苷酸交换因子 RasGRP1 的活化

Yvonne Vercoulen #, Yasushi Kondo #, Jeffrey S Iwig #, Axel B Janssen, Katharine A White, Mojtaba Amini, Diane L Barber, John Kuriyan, Jeroen P Roose

One-way membrane trafficking of SOS in receptor-triggered Ras activation

受体触发的Ras激活中SOS的单向膜运输

Sune M Christensen, Hsiung-Lin Tu, Jesse E Jun, Steven Alvarez, Meredith G Triplet, Jeffrey S Iwig, Kamlesh K Yadav, Dafna Bar-Sagi, Jeroen P Roose, Jay T Groves

Monitoring the Waiting Time Sequence of Single Ras GTPase Activation Events Using Liposome Functionalized Zero-Mode Waveguides

利用脂质体功能化零模波导监测单个Ras GTPase激活事件的等待时间序列

Christensen, Sune M; Triplet, Meredith G; Rhodes, Christopher; Iwig, Jeffrey S; Tu, Hsiung-Lin; Stamou, Dimitrios; Groves, Jay T