日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Fab-Fc and Fab-Fab interactions of variable strength and valency contribute to the high concentration viscosity of IgG(1) antibodies

Fab-Fc 和 Fab-Fab 相互作用的强度和价态各不相同,这导致了 IgG(1) 抗体的高浓度粘度。

Heisler, Joel; Hofmann, Jennifer L; Tan, Zhenyu; Zarzar, Jonathan; Izadi, Saeed; Carter, Paul J

Enhanced direct joint attenuation and scatter correction of whole-body PET images via context-aware deep networks

通过上下文感知深度网络增强全身PET图像的直接联合衰减和散射校正

Izadi, Saeed; Shiri, Isaac; F Uribe, Carlos; Geramifar, Parham; Zaidi, Habib; Rahmim, Arman; Hamarneh, Ghassan

Modulation of the high concentration viscosity of IgG(1) antibodies using clinically validated Fc mutations

利用临床验证的Fc突变调节IgG(1)抗体的高浓度粘度

Heisler, Joel; Kovner, Daniel; Izadi, Saeed; Zarzar, Jonathan; Carter, Paul J

Molecular surface descriptors to predict antibody developability: sensitivity to parameters, structure models, and conformational sampling

利用分子表面描述符预测抗体开发性:对参数、结构模型和构象采样的敏感性

Park, Eliott; Izadi, Saeed

AmberTools

Case, David A; Aktulga, Hasan Metin; Belfon, Kellon; Cerutti, David S; Cisneros, G Andrés; Cruzeiro, Vinícius Wilian D; Forouzesh, Negin; Giese, Timothy J; Götz, Andreas W; Gohlke, Holger; Izadi, Saeed; Kasavajhala, Koushik; Kaymak, Mehmet C; King, Edward; Kurtzman, Tom; Lee, Tai-Sung; Li, Pengfei; Liu, Jian; Luchko, Tyler; Luo, Ray; Manathunga, Madushanka; Machado, Matias R; Nguyen, Hai Minh; O'Hearn, Kurt A; Onufriev, Alexey V; Pan, Feng; Pantano, Sergio; Qi, Ruxi; Rahnamoun, Ali; Risheh, Ali; Schott-Verdugo, Stephan; Shajan, Akhil; Swails, Jason; Wang, Junmei; Wei, Haixin; Wu, Xiongwu; Wu, Yongxian; Zhang, Shi; Zhao, Shiji; Zhu, Qiang; Cheatham, Thomas E 3rd; Roe, Daniel R; Roitberg, Adrian; Simmerling, Carlos; York, Darrin M; Nagan, Maria C; Merz, Kenneth M Jr

Deciphering deamidation and isomerization in therapeutic proteins: Effect of neighboring residue.

解读治疗性蛋白质中的脱酰胺和异构化:邻近残基的影响

Irudayanathan Flaviyan Jerome, Zarzar Jonathan, Lin Jasper, Izadi Saeed

Multiscale Coarse-Grained Approach to Investigate Self-Association of Antibodies

利用多尺度粗粒化方法研究抗体的自缔合

Izadi, Saeed; Patapoff, Thomas W; Walters, Benjamin T

Why Computed Protein Folding Landscapes Are Sensitive to the Water Model

为什么计算得到的蛋白质折叠景观对水模型如此敏感

Anandakrishnan, Ramu; Izadi, Saeed; Onufriev, Alexey V

Accuracy Comparison of Generalized Born Models in the Calculation of Electrostatic Binding Free Energies

广义玻恩模型在静电结合自由能计算中的精度比较

Izadi, Saeed; Harris, Robert C; Fenley, Marcia O; Onufriev, Alexey V

High-Temperature Dynamic Behavior in Bulk Liquid Water: A Molecular Dynamics Simulation Study using the OPC and TIP4P-Ew Potentials

高温下液态水动力学行为:基于OPC和TIP4P-Ew势的分子动力学模拟研究

Gabrieli, Andrea; Sant, Marco; Izadi, Saeed; Shabane, Parviz Seifpanahi; Onufriev, Alexey V; Suffritti, Giuseppe B