日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Proteomic Landscape of Colorectal Cancer Derived Liver Metastasis Reveals Three Distinct Phenotypes With Specific Signaling and Enhanced Survival

结直肠癌肝转移的蛋白质组学图谱揭示了三种具有特定信号传导和增强生存能力的独特表型

Nissen, Paula; Popova, Nadezhda V; Gocke, Antonia; Smit, Daniel J; Wong, Geoffrey Yuet Mun; McKay, Matthew J; Hugh, Thomas J; David, Kerstin; Juhl, Hartmut; Voß, Hannah; Marquardt, Jens U; Nashan, Björn; Schlüter, Hartmut; Molloy, Mark P; Jücker, Manfred

Downregulation of S6 Kinase and Hedgehog-Gli1 by Inhibition of Fatty Acid Synthase in AML with FLT3-ITD Mutation

FLT3-ITD突变型急性髓系白血病中脂肪酸合成酶抑制导致S6激酶和Hedgehog-Gli1下调

Kebenko, Maxim; Zhuang, Ruimeng; Hoffer, Konstantin; Worthmann, Anna; Horn, Stefan; Kriegs, Malte; Vorwerk, Jan; von Bubnoff, Nikolas; Khandanpour, Cyrus; Gebauer, Niklas; Gorantla, Sivahari Prasad; Fiedler, Walter; Bokemeyer, Carsten; Jücker, Manfred

The Role of PI3K/AKT/mTOR Signaling in Tumor Radioresistance and Advances in Inhibitor Research

PI3K/AKT/mTOR信号通路在肿瘤放射抗性中的作用及抑制剂研究进展

Zhan, Jian; Jücker, Manfred

The Inositol-5-Phosphatase SHIP1: Expression, Regulation and Role in Acute Lymphoblastic Leukemia

肌醇-5-磷酸酶SHIP1:表达、调控及其在急性淋巴细胞白血病中的作用

Ehm, Patrick; Jücker, Manfred

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

在小鼠异种移植模型中,靶向 AKT/mTOR 通路可减弱结直肠癌循环肿瘤细胞的转移潜能。

Smit, Daniel J; Pereira-Veiga, Thais; Brauer, Helena; Horn, Michael; Nissen, Paula; Mair, Thomas; Siebels, Bente; Voß, Hannah; Zhuang, Ruimeng; Haider, Marie-Therese; Loreth, Desiree; Iskhakova, Margarita; Lindemann, Bele; Kött, Julian; Cayrefourcq, Laure; Wellbrock, Jasmin; Schlüter, Hartmut; Pantel, Klaus; Alix-Panabières, Catherine; Jücker, Manfred

Ikaros sets the threshold for negative B-cell selection by regulation of the signaling strength of the AKT pathway

Ikaros 通过调节 AKT 通路的信号强度来设定负 B 细胞选择的阈值

Patrick A H Ehm, Stefan Horn, Konstantin Hoffer, Malte Kriegs, Michael Horn, Susanne Giehler, Marcus Nalaskowski, Christoph Rehbach, Martin A Horstmann, Manfred Jücker

K-Ras(V12) differentially affects the three Akt isoforms in lung and pancreatic carcinoma cells and upregulates E-cadherin and NCAM via Akt3

K-Ras(V12) 对肺癌和胰腺癌细胞中的三种 Akt 亚型产生不同的影响,并通过 Akt3 上调 E-cadherin 和 NCAM

Rebekka Geißert, Angela Lammert, Stefanie Wirth, Rabea Hönig, Dirk Lohfink, Monika Unger, Denis Pek, Konstantin Schlüter, Theresa Scheftschik, Daniel J Smit, Manfred Jücker, Andre Menke, Klaudia Giehl

The Functional Roles of the Src Homology 2 Domain-Containing Inositol 5-Phosphatases SHIP1 and SHIP2 in the Pathogenesis of Human Diseases

含有Src同源性2结构域的肌醇5-磷酸酶SHIP1和SHIP2在人类疾病发病机制中的功能作用

Müller, Spike Murphy; Jücker, Manfred

Analysis of the Plasticity of Circulating Tumor Cells Reveals Differentially Regulated Kinases During the Suspension-to-Adherent Transition

循环肿瘤细胞可塑性分析揭示悬浮-贴壁转变过程中差异性调控的激酶

Smit, Daniel J; Hoffer, Konstantin; Bettin, Bettina; Kriegs, Malte; Cayrefourcq, Laure; Schumacher, Udo; Pantel, Klaus; Alix-Panabières, Catherine; Jücker, Manfred

All Three AKT Isoforms Can Upregulate Oxygen Metabolism and Lactate Production in Human Hepatocellular Carcinoma Cell Lines

三种 AKT 同工酶均可上调人肝细胞癌细胞系中的氧代谢和乳酸生成

Ling-Yu Tian ,Daniel J Smit ,Nadezhda V Popova ,Stefan Horn ,Lis Noelia Velasquez ,Samuel Huber ,Manfred Jücker