Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity
靶向布氏锥虫磷酸二酯酶B1 (TbrPDEB1) 的一个亚口袋,可实现基于结构的、具有锥虫杀灭活性的选择性抑制剂的发现。
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.7b01670
Blaazer, Antoni R; Singh, Abhimanyu K; de Heuvel, Erik; Edink, Ewald; Orrling, Kristina M; Veerman, Johan J N; van den Bergh, Toine; Jansen, Chimed; Balasubramaniam, Erin; Mooij, Wouter J; Custers, Hans; Sijm, Maarten; Tagoe, Daniel N A; Kalejaiye, Titilola D; Munday, Jane C; Tenor, Hermann; Matheeussen, An; Wijtmans, Maikel; Siderius, Marco; de Graaf, Chris; Maes, Louis; de Koning, Harry P; Bailey, David S; Sterk, Geert Jan; de Esch, Iwan J P; Brown, David G; Leurs, Rob