日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

SARS-CoV-2 ORF3a induces COVID-19-associated kidney injury through HMGB1-mediated cytokine production

SARS-CoV-2 ORF3a 通过 HMGB1 介导的细胞因子产生诱发 COVID-19 相关肾损伤

Chenyu Zhang, Volodymyr Gerzanich, Ruth Cruz-Cosme, Jiantao Zhang, Orest Tsymbalyuk, Cigdem Tosun, Bhargava Teja Sallapalli, Dongxiao Liu, Kaspar Keledjian, John C Papadimitriou, Cinthia B Drachenberg, Mohamed Nasr, Yanjin Zhang, Qiyi Tang, J Marc Simard, Richard Y Zhao

The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus

脉络丛将先天免疫与脑积水中的脑脊液失调联系起来

Stephanie M Robert ,Benjamin C Reeves ,Emre Kiziltug ,Phan Q Duy ,Jason K Karimy ,M Shahid Mansuri ,Arnaud Marlier ,Garrett Allington ,Ana B W Greenberg ,Tyrone DeSpenza Jr ,Amrita K Singh ,Xue Zeng ,Kedous Y Mekbib ,Adam J Kundishora ,Carol Nelson-Williams ,Le Thi Hao ,Jinwei Zhang ,TuKiet T Lam ,Rashaun Wilson ,William E Butler ,Michael L Diluna ,Philip Feinberg ,Dorothy P Schafer ,Kiavash Movahedi ,Allen Tannenbaum ,Sunil Koundal ,Xinan Chen ,Helene Benveniste ,David D Limbrick Jr ,Steven J Schiff ,Bob S Carter ,Murat Gunel ,J Marc Simard ,Richard P Lifton ,Seth L Alper ,Eric Delpire ,Kristopher T Kahle

Canagliflozin, an Inhibitor of the Na+-Coupled D-Glucose Cotransporter, SGLT2, Inhibits Astrocyte Swelling and Brain Swelling in Cerebral Ischemia

卡格列净是一种 Na+ 偶联 D-葡萄糖转运蛋白 SGLT2 的抑制剂,可抑制脑缺血中的星形胶质细胞肿胀和脑肿胀

Bosung Shim, Jesse A Stokum, Mitchell Moyer, Natalya Tsymbalyuk, Orest Tsymbalyuk, Kaspar Keledjian, Svetlana Ivanova, Cigdem Tosun, Volodymyr Gerzanich, J Marc Simard

Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet induces water influx through AQP4 and brain swelling after ischemic stroke

星形胶质细胞端足中 SUR1-TRPM4 和 NCX1 的阳离子通量诱导缺血性中风后水通过 AQP4 流入和脑肿胀

Jesse A Stokum, Bosung Shim, Serban Negoita, Natalya Tsymbalyuk, Orest Tsymbalyuk, Svetlana Ivanova, Kaspar Keledjian, Joseph Bryan, Mordecai P Blaustein, Ruchira M Jha, Kristopher T Kahle, Volodymyr Gerzanich, J Marc Simard

Brain-targeting, acid-responsive antioxidant nanoparticles for stroke treatment and drug delivery

用于中风治疗和药物输送的脑靶向、酸反应性抗氧化剂纳米粒子

Shenqi Zhang, Bin Peng, Zeming Chen, Jiang Yu, Gang Deng, Youmei Bao, Chao Ma, Fengyi Du, Wendy C Sheu, W Taylor Kimberly, J Marc Simard, Daniel Coman, Qianxue Chen, Fahmeed Hyder, Jiangbing Zhou, Kevin N Sheth

Hypoxanthine is a pharmacodynamic marker of ischemic brain edema modified by glibenclamide

次黄嘌呤是格列本脲修饰的缺血性脑水肿药效学标志物

Hannah J Irvine, Animesh Acharjee, Zoe Wolcott, Zsuzsanna Ament, H E Hinson, Bradley J Molyneaux, J Marc Simard, Kevin N Sheth, W Taylor Kimberly

A Direct Comparison of Physical Versus Dihydrocapsaicin-Induced Hypothermia in a Rat Model of Traumatic Spinal Cord Injury

直接比较大鼠创伤性脊髓损伤模型中物理诱导和二氢辣椒素诱导的低温

Amrita Sarkar, Kevin T Kim, Orest Tsymbalyuk, Kaspar Keledjian, Bradley E Wilhelmy, Nageen A Sherani, Xiaofeng Jia, Volodymyr Gerzanich, J Marc Simard

Genome-Wide Characterization of SARS-CoV-2 Cytopathogenic Proteins in the Search of Antiviral Targets

对 SARS-CoV-2 细胞致病蛋白进行全基因组表征以寻找抗病毒靶点

Jiantao Zhang, Qi Li, Ruth S Cruz Cosme, Volodymyr Gerzanich, Qiyi Tang, J Marc Simard, Richard Y Zhao

A large portion of the astrocyte proteome is dedicated to perivascular endfeet, including critical components of the electron transport chain

星形胶质细胞蛋白质组的很大一部分专门用于血管周围终足,包括电子传递链的关键成分

Jesse A Stokum, Bosung Shim, Weiliang Huang, Maureen Kane, Jesse A Smith, Volodymyr Gerzanich, J Marc Simard

SUR1, newly expressed in astrocytes, mediates neuropathic pain in a mouse model of peripheral nerve injury

在星形胶质细胞中新表达的 SUR1 介导小鼠外周神经损伤模型中的神经性疼痛

Orest Tsymbalyuk, Volodymyr Gerzanich, Aaida Mumtaz, Sanketh Andhavarapu, Svetlana Ivanova, Tapas K Makar, Charles A Sansur, Asaf Keller, Yumiko Nakamura, Joseph Bryan, J Marc Simard