日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations

大规模泛癌细胞系筛选可确定可行且有效的药物组合

Azadeh C Bashi #, Elizabeth A Coker #, Krishna C Bulusu #, Patricia Jaaks #, Claire Crafter #, Howard Lightfoot, Marta Milo, Katrina McCarten, David F Jenkins, Dieudonne van der Meer, James T Lynch, Syd Barthorpe, Courtney L Andersen, Simon T Barry, Alexandra Beck, Justin Cidado, Jacob A Gordon, Cai

Author Correction: Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers

作者更正:IAG933 通过直接和选择性地药理学手段破坏 YAP-TEAD 界面,从而抑制 Hippo 依赖性和 RAS-MAPK 改变的癌症。

Chapeau, Emilie A; Sansregret, Laurent; Galli, Giorgio G; Chène, Patrick; Wartmann, Markus; Mourikis, Thanos P; Jaaks, Patricia; Baltschukat, Sabrina; Barbosa, Ines A M; Bauer, Daniel; Brachmann, Saskia M; Delaunay, Clara; Estadieu, Claire; Faris, Jason E; Furet, Pascal; Harlfinger, Stefanie; Hueber, Andreas; Jiménez Núñez, Eloísa; Kodack, David P; Mandon, Emeline; Martin, Typhaine; Mesrouze, Yannick; Romanet, Vincent; Scheufler, Clemens; Sellner, Holger; Stamm, Christelle; Sterker, Dario; Tordella, Luca; Hofmann, Francesco; Soldermann, Nicolas; Schmelzle, Tobias

Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers

IAG933通过直接和选择性地药理学手段破坏YAP-TEAD界面,从而抑制Hippo依赖性和RAS-MAPK改变的癌症。

Emilie A Chapeau ,Laurent Sansregret ,Giorgio G Galli ,Patrick Chène ,Markus Wartmann ,Thanos P Mourikis ,Patricia Jaaks ,Sabrina Baltschukat ,Ines A M Barbosa ,Daniel Bauer ,Saskia M Brachmann ,Clara Delaunay ,Claire Estadieu ,Jason E Faris ,Pascal Furet ,Stefanie Harlfinger ,Andreas Hueber ,Eloísa Jiménez Núñez ,David P Kodack ,Emeline Mandon ,Typhaine Martin ,Yannick Mesrouze ,Vincent Romanet ,Clemens Scheufler ,Holger Sellner ,Christelle Stamm ,Dario Sterker ,Luca Tordella ,Francesco Hofmann ,Nicolas Soldermann ,Tobias Schmelzle

A pan-cancer screen identifies drug combination benefit in cancer cell lines at the individual and population level

泛癌筛选可在个体和群体水平上识别癌细胞系中的药物组合获益。

Vis, Daniel J; Jaaks, Patricia; Aben, Nanne; Coker, Elizabeth A; Barthorpe, Syd; Beck, Alexandra; Hall, Caitlin; Hall, James; Lightfoot, Howard; Lleshi, Ermira; Mironenko, Tatiana; Richardson, Laura; Tolley, Charlotte; Garnett, Mathew J; Wessels, Lodewyk F A

Effective drug combinations in breast, colon and pancreatic cancer cells

乳腺癌、结肠癌和胰腺癌细胞的有效药物组合

Patricia Jaaks #, Elizabeth A Coker #, Daniel J Vis, Olivia Edwards, Emma F Carpenter, Simonetta M Leto, Lisa Dwane, Francesco Sassi, Howard Lightfoot, Syd Barthorpe, Dieudonne van der Meer, Wanjuan Yang, Alexandra Beck, Tatiana Mironenko, Caitlin Hall, James Hall, Iman Mali, Laura Richardson, Charl

AKT-mTORC1 reactivation is the dominant resistance driver for PI3Kβ/AKT inhibitors in PTEN-null breast cancer and can be overcome by combining with Mcl-1 inhibitors

AKT-mTORC1 重新激活是 PTEN 基因缺失的乳腺癌中 PI3Kβ/AKT 抑制剂产生耐药性的主要驱动因素,可通过与 Mcl-1 抑制剂联合使用来克服

Shanade Dunn, Cath Eberlein, Jason Yu, Albert Gris-Oliver, Swee Hoe Ong, Urs Yelland, Natalie Cureton, Anna Staniszewska, Robert McEwen, Millie Fox, James Pilling, Philip Hopcroft, Elizabeth A Coker, Patricia Jaaks, Mathew J Garnett, Beverley Isherwood, Violeta Serra, Barry R Davies, Simon T Barry, 

SLFN11 informs on standard of care and novel treatments in a wide range of cancer models

SLFN11 为多种癌症模型的护理标准和新疗法提供信息

Claudia Winkler, Joshua Armenia, Gemma N Jones, Luis Tobalina, Matthew J Sale, Tudor Petreus, Tarrion Baird, Violeta Serra, Anderson T Wang, Alan Lau, Mathew J Garnett, Patricia Jaaks, Elizabeth A Coker, Andrew J Pierce, Mark J O'Connor, Elisabetta Leo

Patient-specific logic models of signaling pathways from screenings on cancer biopsies to prioritize personalized combination therapies

通过癌症活检筛查建立针对患者的具体信号通路逻辑模型,优先考虑个性化联合疗法

Federica Eduati, Patricia Jaaks, Jessica Wappler, Thorsten Cramer, Christoph A Merten, Mathew J Garnett, Julio Saez-Rodriguez

USP19 deubiquitinates EWS-FLI1 to regulate Ewing sarcoma growth

USP19 去泛素化 EWS-FLI1 来调节尤文氏肉瘤的生长

Maria E Gierisch, Gloria Pedot, Franziska Walser, Laura A Lopez-Garcia, Patricia Jaaks, Felix K Niggli, Beat W Schäfer

Targeting hedgehog signaling reduces self-renewal in embryonal rhabdomyosarcoma

靶向刺猬信号可降低胚胎横纹肌肉瘤的自我更新

S Satheesha, G Manzella, A Bovay, E A Casanova, P K Bode, R Belle, S Feuchtgruber, P Jaaks, N Dogan, E Koscielniak, B W Schäfer