日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

YAP1 is essential for malignant mesothelioma tumor maintenance

YAP1 对恶性间皮瘤肿瘤维持至关重要

Loreley Calvet, Odette Dos-Santos, Emmanuel Spanakis, Véronique Jean-Baptiste, Jean-Christophe Le Bail, Armelle Buzy, Pascal Paul, Christophe Henry, Sandrine Valence, Colette Dib, Jack Pollard, Sukhvinder Sidhu, Jürgen Moll, Laurent Debussche, Iris Valtingojer

SAR439859, a Novel Selective Estrogen Receptor Degrader (SERD), Demonstrates Effective and Broad Antitumor Activity in Wild-Type and Mutant ER-Positive Breast Cancer Models

SAR439859 是一种新型选择性雌激素受体降解剂 (SERD),在野生型和突变型 ER 阳性乳腺癌模型中表现出有效且广泛的抗肿瘤活性

Maysoun Shomali, Jane Cheng, Fangxian Sun, Malvika Koundinya, Zhuyan Guo, Andrew T Hebert, Jessica McManus, Mikhail N Levit, Dietmar Hoffmann, Albane Courjaud, Rosalia Arrebola, Hui Cao, Jack Pollard, Joon Sang Lee, Laurent Besret, Anne Caron, Dinesh S Bangari, Pierre-Yves Abecassis, Laurent Schio, 

An experimental model of anti-PD-1 resistance exhibits activation of TGFß and Notch pathways and is sensitive to local mRNA immunotherapy

抗 PD-1 耐药的实验模型表现出 TGFβ 和 Notch 通路的激活,并且对局部 mRNA 免疫疗法敏感

Marie Bernardo, Tatiana Tolstykh, Yu-An Zhang, Dinesh S Bangari, Hui Cao, Kerstin A Heyl, Joon Sang Lee, Natalia V Malkova, Katie Malley, Eladio Marquez, Jack Pollard, Hui Qu, Errin Roberts, Sue Ryan, Kuldeep Singh, Fangxian Sun, Emma Wang, Keith Bahjat, Dmitri Wiederschain, Timothy R Wagenaar

Pan-TGFβ inhibition by SAR439459 relieves immunosuppression and improves antitumor efficacy of PD-1 blockade

SAR439459 抑制泛 TGFβ 可缓解免疫抑制并提高 PD-1 阻断的抗肿瘤功效

Rita Greco, Hongjing Qu, Hui Qu, Joachim Theilhaber, Gary Shapiro, Richard Gregory, Christopher Winter, Natalia Malkova, Frank Sun, Julie Jaworski, Annie Best, Lily Pao, Andrew Hebert, Mikhail Levit, Alexei Protopopov, Jack Pollard, Keith Bahjat, Dmitri Wiederschain, Sharad Sharma

Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression synergizes with mTOR inhibition

谷氨酰胺酶对于谷氨酰胺代谢途径失调的三阴性乳腺癌细胞的生长至关重要,其抑制与 mTOR 抑制有协同作用

Michael Lampa, Heike Arlt, Timothy He, Beatriz Ospina, Jason Reeves, Bailin Zhang, Joshua Murtie, Gejing Deng, Claude Barberis, Dietmar Hoffmann, Hong Cheng, Jack Pollard, Christopher Winter, Victoria Richon, Carlos Garcia-Escheverria, Francisco Adrian, Dmitri Wiederschain, Lakshmi Srinivasan

Combination of PIM and JAK2 inhibitors synergistically suppresses MPN cell proliferation and overcomes drug resistance

PIM 与 JAK2 抑制剂联合使用可协同抑制 MPN 细胞增殖并克服耐药性

Shih-Min A Huang, Anlai Wang, Rita Greco, Zhifang Li, Claude Barberis, Michel Tabart, Vinod Patel, Laurent Schio, Raelene Hurley, Bo Chen, Hong Cheng, Christoph Lengauer, Jack Pollard, James Watters, Carlos Garcia-Echeverria, Dmitri Wiederschain, Francisco Adrian, JingXin Zhang