日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Bioengineered small extracellular vesicles deliver multiple SARS-CoV-2 antigenic fragments and drive a broad immunological response

生物工程改造的小型细胞外囊泡可递送多种SARS-CoV-2抗原片段,并引发广泛的免疫反应。

Hannah K Jackson ,Heather M Long ,Juan Carlos Yam-Puc ,Roberta Palmulli ,Tracey A Haigh ,Pehuén Pereyra Gerber ,Jin S Lee ,Nicholas J Matheson ,Lesley Young ,John Trowsdale ,Mathew Lo ,Graham S Taylor ,James E Thaventhiran ,James R Edgar

Results of a randomized, double-blind phase II clinical trial of NY-ESO-1 vaccine with ISCOMATRIX adjuvant versus ISCOMATRIX alone in participants with high-risk resected melanoma

一项随机、双盲 II 期临床试验的结果显示,在接受切除手术的高危黑色素瘤患者中,NY-ESO-1 疫苗联合 ISCOMATRIX 佐剂与单独使用 ISCOMATRIX 佐剂的疗效存在差异。

Cebon, Jonathan S; Gore, Martin; Thompson, John F; Davis, Ian D; McArthur, Grant A; Walpole, Euan; Smithers, Mark; Cerundolo, Vincenzo; Dunbar, P Rod; MacGregor, Duncan; Fisher, Cyril; Millward, Michael; Nathan, Paul; Findlay, Michael P N; Hersey, Peter; Evans, T R Jeffry; Ottensmeier, Christian Hermann; Marsden, Jeremy; Dalgleish, Angus G; Corrie, Pippa G; Maria, Marples; Brimble, Margaret; Williams, Geoff; Winkler, Sintia; Jackson, Heather M; Endo-Munoz, Liliana; Tutuka, Candani S A; Venhaus, Ralph; Old, Lloyd J; Haack, Dennis; Maraskovsky, Eugene; Behren, Andreas; Chen, Weisan

Immunoediting and persistence of antigen-specific immunity in patients who have previously been vaccinated with NY-ESO-1 protein formulated in ISCOMATRIX™

免疫编辑和抗原特异性免疫在先前接种过 ISCOMATRIX™ 配方 NY-ESO-1 蛋白疫苗的患者中的持久性

Nicholaou, Theo; Chen, Weisan; Davis, Ian D; Jackson, Heather M; Dimopoulos, Nektaria; Barrow, Catherine; Browning, Judy; Macgregor, Duncan; Williams, David; Hopkins, Wendie; Maraskovsky, Eugene; Venhaus, Ralph; Pan, Linda; Hoffman, Eric W; Old, Lloyd J; Cebon, Jonathan

Nox5 forms a functional oligomer mediated by self-association of its dehydrogenase domain.

Nox5 通过其脱氢酶结构域的自缔合形成功能性寡聚体

Kawahara Tsukasa, Jackson Heather M, Smith Susan M E, Simpson Paul D, Lambeth J David

E1--E4-mediated keratin phosphorylation and ubiquitylation: a mechanism for keratin depletion in HPV16-infected epithelium

E1-E4 介导的角蛋白磷酸化和泛素化:HPV16 感染上皮细胞角蛋白耗竭的机制

Pauline B McIntosh, Peter Laskey, Kate Sullivan, Clare Davy, Qian Wang, Deborah J Jackson, Heather M Griffin, John Doorbar