日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Publisher Correction: Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome

出版商更正:靶向NAT10可延长人类加速衰老综合征小鼠模型的健康寿命

Balmus, Gabriel; Larrieu, Delphine; Barros, Ana C; Collins, Casey; Abrudan, Monica; Demir, Mukerrem; Geisler, Nicola J; Lelliott, Christopher J; White, Jacqueline K; Karp, Natasha A; Atkinson, James; Kirton, Andrea; Jacobsen, Matt; Clift, Dean; Rodriguez, Raphael; Adams, David J; Jackson, Stephen P

ERCC6L2 ensures repair fidelity for staggered-end DNA double-strand breaks.

ERCC6L2 确保交错末端 DNA 双链断裂的修复保真度。

Aird Eric J, Serrano-Benitez Almudena, Siegner Sebastian M, Cannavo Elda, Belotserkovskaya Rimma, Gueorguieva Nadia, Fielden John, Cullot Grégoire, Ammann Sandra, Bader Aldo S, Gupta Vipul, Andrieux Geoffroy, Raab Rebecca, Del Rey González Mónica, Cathomen Toni, Cejka Petr, Corn Jacob E, Jackson Stephen P

Loss of CTLH component MAEA impairs DNA repair and replication and leads to developmental delay.

CTLH 成分 MAEA 的缺失会损害 DNA 修复和复制,并导致发育迟缓。

Hough Søren H, Jhujh Satpal S, Awwad Samah W, Lewis Oliver E, Lam Simon, Thomas John C, Mosler Thorsten, Bader Aldo, Bartik Lauren, McKee Shane, Amudhavalli Shivarajan, Colin Estelle, Damseh Nadirah, Clement Emma, Cacheiro Pilar, Majumdar Anirban, Smedley Damian, Fluss Joël, Giannini Rosalinda, Thiffault Isabelle, Zagnoli Vieira Guido, Belotserkovskaya Rimma, Smerdon Stephen J, Beli Petra, Galanty Yaron, Carnie Christopher J, Stewart Grant S, Jackson Stephen P

MDC1 counteracts replication fork reversal and mediates chemosensitivity in BRCA1/2-deficient tumors.

MDC1 可对抗复制叉逆转,并介导 BRCA1/2 缺陷型肿瘤的化疗敏感性。

Dogan Hülya, Liptay Martin, Barbosa Joana S, Gogola Ewa, Duarte Alexandra A, Schmid Jonas A, Klebic Ismar, Mutlu Merve, Siffert Myriam, Francica Paola, Salguero Israel, van de Ven Marieke, de Korte-Grimmerink Renske, Jackson Stephen P, Jonkers Jos, Lopes Massimo, Dibitetto Diego, Rottenberg Sven

Comprehensive interrogation of synthetic lethality in the DNA damage response.

对DNA损伤反应中的合成致死性进行全面研究

Fielden John, Siegner Sebastian M, Gallagher Danielle N, Schröder Markus S, Dello Stritto Maria Rosaria, Lam Simon, Kobel Lena, Schlapansky Moritz F, Jackson Stephen P, Cejka Petr, Jost Marco, Corn Jacob E

USP4 Auto-Deubiquitylation Promotes Homologous Recombination

USP4自身去泛素化促进同源重组

Wijnhoven, Paul; Konietzny, Rebecca; Blackford, Andrew N; Travers, Jonathan; Kessler, Benedikt M; Nishi, Ryotaro; Jackson, Stephen P

USP37 prevents premature disassembly of stressed replisomes by TRAIP

USP37通过TRAIP阻止受损复制体的过早解体。

Kochenova, Olga V; D'Alessandro, Giuseppina; Pilger, Domenic; Schmid, Ernst; Richards, Sean L; Garcia, Marcos Rios; Jhujh, Satpal S; Voigt, Andrea; Gupta, Vipul; Carnie, Christopher J; Alex Wu, R; Gueorguieva, Nadia; Lam, Simon; Stewart, Grant S; Walter, Johannes C; Jackson, Stephen P

Imaging flow cytometry-based cellular screening elucidates pathophysiology in individuals with Variants of Uncertain Significance

基于成像流式细胞术的细胞筛查阐明了具有意义未明变异的个体的病理生理学

Muffels, Irena Josephina Johanna; Waterham, Hans R; D'Alessandro, Giuseppina; Zagnoli-Vieira, Guido; Sacher, Michael; Lefeber, Dirk J; Van der Vinne, Celine; Roifman, Chaim M; Gassen, Koen L I; Rehmann, Holger; Van Haaften-Visser, Desiree Y; Nieuwenhuis, Edward S S; Jackson, Stephen P; Fuchs, Sabine A; Wijk, Femke; van Hasselt, Peter

Cell-stereotyped DNA repair outcomes are widespread during genome editing

在基因组编辑过程中,细胞刻板的DNA修复结果普遍存在。

Schlapansky, Moritz F; Schröder, Markus S; Santinha, Antonio J; Rothgangl, Tanja; Ioannidi, Eleonora I; Cullot, Grégoire; Lewkow, Bohdan; Ortega, German Camargo; Nouraiz, Ahmed; Mailänder, Dominic; Selbert, Louisa; Lam, Simon; Egea, Aitana; Shin, Jiyung J; Bordi, Matteo; DeWitt, Mark; Gvozdenovic, Ana; Jackson, Stephen P; Schroeder, Timm; Gehart, Helmuth; Schwank, Gerald; Platt, Randall J; Corn, Jacob E

Genome-aware annotation of CRISPR guides validates targets in variant cell lines and enhances discovery in screens

基于基因组感知的 CRISPR 指导序列注释可以验证变异细胞系中的靶标,并增强筛选中的发现能力。

Lam, Simon; Thomas, John C; Jackson, Stephen P