日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Preclinical evaluation for engraftment of CD34+ cells gene-edited at the sickle cell disease locus in xenograft mouse and non-human primate models

在异种移植小鼠和非人类灵长类动物模型中对镰状细胞病基因座进行基因编辑的 CD34+ 细胞植入的临床前评估

Naoya Uchida, Linhong Li, Tina Nassehi, Claire M Drysdale, Morgan Yapundich, Jackson Gamer, Juan J Haro-Mora, Selami Demirci, Alexis Leonard, Aylin C Bonifacino, Allen E Krouse, N Seth Linde, Cornell Allen, Madhusudan V Peshwa, Suk See De Ravin, Robert E Donahue, Harry L Malech, John F Tisdale

Cas9 protein delivery non-integrating lentiviral vectors for gene correction in sickle cell disease

Cas9 蛋白递送非整合慢病毒载体用于镰状细胞病的基因校正

Naoya Uchida, Claire M Drysdale, Tina Nassehi, Jackson Gamer, Morgan Yapundich, Julia DiNicola, Yoshitaka Shibata, Malikiya Hinds, Bjorg Gudmundsdottir, Juan J Haro-Mora, Selami Demirci, John F Tisdale

βT87Q-Globin Gene Therapy Reduces Sickle Hemoglobin Production, Allowing for Ex Vivo Anti-sickling Activity in Human Erythroid Cells

βT87Q-珠蛋白基因疗法可减少镰状血红蛋白的产生,从而实现人类红细胞体外抗镰状细胞活性

Selami Demirci, Bjorg Gudmundsdottir, Quan Li, Juan J Haro-Mora, Tina Nassehi, Claire Drysdale, Morgan Yapundich, Jackson Gamer, Fayaz Seifuddin, John F Tisdale, Naoya Uchida

Fetal hemoglobin and F-cell variance in mobilized CD34+ cell-transplanted rhesus monkeys

动员 CD34+ 细胞移植恒河猴的胎儿血红蛋白和 F 细胞变异

Selami Demirci, Juan J Haro Mora, Morgan Yapundich, Claire Drysdale, Jackson Gamer, Tina Nassehi, Aylin C Bonifacino, Allen E Krouse, Nathaniel S Linde, Robert E Donahue, John F Tisdale, Naoya Uchida

Low-Dose Busulfan Reduces Human CD34+ Cell Doses Required for Engraftment in c-kit Mutant Immunodeficient Mice

低剂量白消安可降低 c-kit 突变免疫缺陷小鼠植入所需的人类 CD34+ 细胞剂量

Alexis Leonard, Morgan Yapundich, Tina Nassehi, Jackson Gamer, Claire M Drysdale, Juan J Haro-Mora, Selami Demirci, Matthew M Hsieh, Naoya Uchida, John F Tisdale

High-Efficiency Lentiviral Transduction of Human CD34+ Cells in High-Density Culture with Poloxamer and Prostaglandin E2

利用泊洛沙姆和前列腺素 E2 对高密度培养的人类 CD34+ 细胞进行高效慢病毒转导

Naoya Uchida, Tina Nassehi, Claire M Drysdale, Jackson Gamer, Morgan Yapundich, Selami Demirci, Juan J Haro-Mora, Alexis Leonard, Matthew M Hsieh, John F Tisdale

The Role of Bmp2 in the Maturation and Maintenance of the Murine Knee Joint

Bmp2 在小鼠膝关节成熟和维持中的作用

Laura W Gamer, Steven Pregizer, Jackson Gamer, Marina Feigenson, Andreia Ionescu, Qing Li, Lin Han, Vicki Rosen