日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Functional Precision Medicine Using MicroOrganoSpheres for Treatment Response Prediction in Advanced Colorectal Cancer

利用微球进行功能性精准医学预测晚期结直肠癌的治疗反应

Gobits, Roán; Schleußner, Nikolai; Oliver, Gavin R; Rutenberg Schoenberg, Michael; de Jesus Domingues, António Miguel; Ramkumar, Pavan; Suen, Sylvia W F; Koomen, Mandy P M; Paolucci, Francesca; Martens, Kilian; Guiseris Martinez, Aitana; Volk, Julia; Artmann, Carolin; Mastel, Manuel; Ouyang, Kyanna S; Kloor, Matthias; Bankaitis, Eric Daniel; Stoub, Hayden Eric; Puschhof, Jens; Brown, Kevin; Pretzer, Sebastian; Nelson, Daniel A; Struminger, Eric; Zessin, Amelia; Brown, Amanda; Evans, Corey; Yetsko, Daniel; Harrington, Mackenzie; Salg, Gabriel; Schneider, Martin; Schmidt, Thomas; Helman, Elena; Plenker, Dennis; Barnett, Carlton; Jones, Ryan T; Köhler, Bruno; Driehuis, Else; Jackstadt, Rene

Transient exposure to bisphenol F in early life affects the metabolic health of adults

生命早期短暂接触双酚F会影响成年人的代谢健康。

Gadara, Darshak; Schwaiger-Haber, Michaela; Jackstadt, Madelyn M; Song, Mun-Gu; Guo, Qiuyuan; Barr, Madison; Bakulski, Kelly M; Shriver, Leah P; Patti, Gary J

Enterocyte-like differentiation defines metabolic gene signatures of CMS3 colorectal cancers and provides therapeutic vulnerability.

肠细胞样分化定义了 CMS3 结直肠癌的代谢基因特征,并提供了治疗靶点

Torang Arezo, Kirov Aleksandar B, Lammers Veerle, Cameron Kate, Wouters Valérie M, Jackstadt Rene F, Lannagan Tamsin R M, de Jong Joan H, Koster Jan, Sansom Owen, Medema Jan Paul

Maintenance of p-eIF2α levels by the eIF2B complex is vital for colorectal cancer

eIF2B复合物维持p-eIF2α水平对结直肠癌至关重要。

Ivana Paskov Škapik # ,Chiara Giacomelli # ,Sarah Hahn ,Hanna Deinlein ,Peter Gallant ,Mathias Diebold ,Josep Biayna ,Anne Hendricks ,Leon Olimski ,Christoph Otto ,Carolin Kastner ,Elmar Wolf ,Christina Schülein-Völk ,Katja Maurus ,Andreas Rosenwald ,Nikolai Schleussner ,Rene-Filip Jackstadt ,Nicolas Schlegel ,Christoph-Thomas Germer ,Martin Bushell ,Martin Eilers ,Stefanie Schmidt ,Armin Wiegering

CDX2 downregulation regulates intrinsic WNT pathway activation, dictating metastasis in APC and CTNNB1 wildtype colorectal cancer.

CDX2 下调调节内在 WNT 通路激活,决定 APC 和 CTNNB1 野生型结直肠癌的转移

Wouters Valérie M, Helderman Roxan F C P A, Cameron Kate, van der Hooff Sander R, Torang Arezo, van den Bergh Saskia, Jackstadt Rene, Sansom Owen J, van Neerven Sanne M, Medema Jan Paul

Intestine-derived sorbitol drives steatotic liver disease in the absence of gut bacteria.

肠道来源的山梨醇在缺乏肠道细菌的情况下会引发脂肪肝疾病。

Jackstadt Madelyn M, Fowle-Grider Ronald, Song Mun-Gu, Ward Matthew H, Barr Madison, Cho Kevin, Palacios Hector H, Klein Samuel, Shriver Leah P, Patti Gary J

Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes

尿苷磷酸化酶-1通过改变免疫和细胞外基质环境来促进转移

Declan Whyte ,Sophie L Fisher ,Christopher G J McKenzie ,David Sumpton ,Sandeep Dhayade ,Emmanuel Dornier ,Madeleine Moore ,David Novo ,Jasmine Peters ,Robert Wiesheu ,Michalis D Gounis ,Dale M Watt ,John B G Mackey ,Amanda J McFarlane ,Frédéric Fercoq ,Carolina Dehesa Caballero ,Keara L Redmond ,Louise E Mitchell ,Eve Anderson ,Gemma Thomson ,Ann Hedley ,William Clark ,Shannen Leroi ,Lindsey N Dzierozynski ,Juan J Apiz Saab ,Caroline A Lewis ,Alexander Muir ,Christopher J Halbrook ,Douglas Strathdee ,Rene Jackstadt ,Colin Nixon ,Philip Dunne ,Leo M Carlin ,Iain R Macpherson ,Edward W Roberts ,Seth B Coffelt ,Karen Blyth ,Owen J Sansom ,Jim C Norman ,Johan Vande Voorde ,Cassie J Clarke

Correction: Characterizing Neutrophil Subtypes in Cancer Using scRNA Sequencing Demonstrates the Importance of IL1β/CXCR2 Axis in Generation of Metastasis-Specific Neutrophils

更正:利用单细胞RNA测序对癌症中性粒细胞亚型进行表征,揭示了IL1β/CXCR2轴在转移特异性中性粒细胞生成中的重要性

Fetit, Rana; McLaren, Alistair S; White, Mark; Mills, Megan L; Falconer, John; Cortes-Lavaud, Xabier; Gilroy, Kathryn; Lannagan, Tamsin R M; Ridgway, Rachel A; Nixon, Colin; Naiker, Varushka; Njunge, Renee; Clarke, Cassie J; Whyte, Declan; Kirschner, Kristina; Jackstadt, Rene; Norman, Jim; Carlin, Leo M; Campbell, Andrew D; Sansom, Owen J; Steele, Colin W

TROPHIT1-a randomized, open-label, multicenter, phase II/III trial of sacituzumab govitecan compared to standard of care in metastatic colorectal cancer patients

TROPHIT1 是一项随机、开放标签、多中心 II/III 期临床试验,旨在比较 sacituzumab govitecan 与转移性结直肠癌患者的标准治疗方案。

Köhler, B C; Haag, G M; Le Cornet, L; Hoffmeister-Wittmann, P; Schmidt, M; Manjunath, A; Vaquero-Siguero, N; Jenzer, M; Gimmel, M; Stahler, A; Stein, A; Reichert, M; Kasper, S; Bitzer, M; Jäger, D; Springfeld, C; Weber, T F; Fröhling, S; Steindorf, K; Trumpp, A; Schlenk, R F; Jackstadt, R

Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer

膳食果糖通过器官间脂质转移间接促进肿瘤生长。

Fowle-Grider, Ronald; Rowles, Joe L 3rd; Shen, Isabel; Wang, Yahui; Schwaiger-Haber, Michaela; Dunham, Alden J; Jayachandran, Kay; Inkman, Matthew; Zahner, Michael; Naser, Fuad J; Jackstadt, Madelyn M; Spalding, Jonathan L; Chiang, Sarah; McCommis, Kyle S; Dolle, Roland E; Kramer, Eva T; Zimmerman, Sarah M; Souroullas, George P; Finck, Brian N; Shriver, Leah P; Kaufman, Charles K; Schwarz, Julie K; Zhang, Jin; Patti, Gary J