IL-18 metabolically reprograms CAR-expressing natural killer T cells and enhances their antitumor activity.
IL-18 通过代谢重编程表达 CAR 的自然杀伤 T 细胞，增强其抗肿瘤活性。
期刊:Molecular Therapy
影响因子:12
doi:10.1016/j.ymthe.2026.01.001
Barragán Bravo Gabriel A, de la Cerda David A, Landoni Elisa, Dholakia Kshiti, Humeniuk Piotr, Caraballo Galva Leidy D, Wang Ying, Tian Gengwen, Yang Boning, Guo Linjie, Wood Michael S, Rios Xavier, Xu Xin, Courtney Amy N, Di Pierro Erica J, Jacob Joan, Li Yi-Han, Adaikkalavan Akshaya, Watanabe Norihiro, Mao Sufeng, Miles George, Dotti Gianpietro, Metelitsa Leonid S
肿瘤
T细胞
肿瘤免疫
代谢
代谢重编程
细胞生物学
IL-18
