日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication

不仅仅是酰胺生物电子等排体:发现含 1,2,4-三唑的吡唑并[1,5- a]嘧啶宿主 CSNK2 抑制剂用于对抗 β-冠状病毒复制

Han Wee Ong, Xuan Yang, Jeffery L Smith, Rebekah J Dickmander, Jason W Brown, Tammy M Havener, Sharon Taft-Benz, Stefanie Howell, Marcia K Sanders, Jacob L Capener, Rafael M Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David H Drewry, Timothy M Willson

Development of SYK NanoBRET Cellular Target Engagement Assays for Gain-of-Function Variants

针对获得功能变体的 SYK NanoBRET 细胞靶标参与检测的开发

Jacob L Capener, James D Vasta, Vittorio L Katis, Ani Michaud, Michael T Beck, Sabrina C D Daglish, Sarit Cohen-Kedar, Efrat Shaham Barda, Stefanie Howell, Iris Dotan, Matthew B Robers, Alison D Axtman, Frances M Bashore

A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction

SMOOTHENED 中的 PKA 抑制剂基序控制 Hedgehog 信号转导

John T Happ #, Corvin D Arveseth #, Jessica Bruystens #, Daniela Bertinetti #, Isaac B Nelson #, Cristina Olivieri #, Jingyi Zhang, Danielle S Hedeen, Ju-Fen Zhu, Jacob L Capener, Jan W Bröckel, Lily Vu, C C King, Victor L Ruiz-Perez, Xuecai Ge, Gianluigi Veglia, Friedrich W Herberg, Susan S Taylor,

Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits

Smoothened 通过活性依赖性 PKA 催化亚单位隔离来传递 Hedgehog 信号

Corvin D Arveseth, John T Happ, Danielle S Hedeen, Ju-Fen Zhu, Jacob L Capener, Dana Klatt Shaw, Ishan Deshpande, Jiahao Liang, Jiewei Xu, Sara L Stubben, Isaac B Nelson, Madison F Walker, Kouki Kawakami, Asuka Inoue, Nevan J Krogan, David J Grunwald, Ruth Hüttenhain, Aashish Manglik, Benjamin R Mye