IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein
IL-2 在肿瘤的酸性 pH 环境中失活,因此可以设计出 pH 选择性突变蛋白
期刊:Science Immunology
影响因子:17.6
doi:10.1126/sciimmunol.ade5686
Silvia Gaggero, Jonathan Martinez-Fabregas, Adeline Cozzani, Paul K Fyfe, Malo Leprohon, Jie Yang, F Emil Thomasen, Hauke Winkelmann, Romain Magnez, Alberto G Conti, Stephan Wilmes, Elizabeth Pohler, Manuel van Gijsel Bonnello, Xavier Thuru, Bruno Quesnel, Fabrice Soncin, Jacob Piehler, Kresten Lind