日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Design of facilitated dissociation enables timing of cytokine signalling

促进解离的设计能够控制细胞因子信号的时序

Adam J Broerman ,Christoph Pollmann ,Yang Zhao ,Mauriz A Lichtenstein ,Mark D Jackson ,Maxx H Tessmer ,Won Hee Ryu ,Masato Ogishi ,Mohamad H Abedi ,Danny D Sahtoe ,Aza Allen ,Alex Kang ,Joshmyn De La Cruz ,Evans Brackenbrough ,Banumathi Sankaran ,Asim K Bera ,Daniel M Zuckerman ,Stefan Stoll ,K Christopher Garcia ,Florian Praetorius ,Jacob Piehler ,David Baker

Tuning of G-CSFR signaling by de novo-designed agonists

通过从头设计的激动剂调节 G-CSFR 信号传导

Timo Ullrich ,Christoph Pollmann ,Malte Ritter ,Jérémy Haaf ,Narges Aghaallaei ,Ivan Tesakov ,Valeriia Hatskovska ,Maya El-Riz ,Kateryna Maksymenko ,Sergey Kandabarau ,Maksim Klimiankou ,Claudia Lengerke ,Karl Welte ,Birte Hernandez-Alvarez ,Patrick Müller ,Andrei Lupas ,Jacob Piehler ,Julia Skokowa ,Mohammad ElGamacy

Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency

对 IL-11 介导的信号传导和人类 IL6ST 变异相关免疫缺陷的结构洞察

Scott Gardner #, Yibo Jin #, Paul K Fyfe #, Tomas B Voisin, Junel Sotolongo Bellón, Elizabeth Pohler, Jacob Piehler, Ignacio Moraga, Doryen Bubeck

Glia trigger endocytic clearance of axonal proteins to promote rodent myelination

神经胶质细胞触发轴突蛋白的内吞清除,从而促进啮齿动物髓鞘形成。

Yoko Bekku,Brendan Zotter,Changjiang You,Jacob Piehler,Warren J Leonard,James L Salzer

A strategy to design protein-based antagonists against type I cytokine receptors

设计针对I型细胞因子受体的蛋白质拮抗剂的策略

Timo Ullrich ,Olga Klimenkova ,Christoph Pollmann ,Asma Lasram ,Valeriia Hatskovska ,Kateryna Maksymenko ,Matej Milijaš-Jotić ,Lukas Schenk ,Claudia Lengerke ,Marcus D Hartmann ,Jacob Piehler ,Julia Skokowa ,Mohammad ElGamacy

Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis

血小板生成素-MPL受体复合物的结构是偏向造血的蓝图

Naotaka Tsutsumi,Zahra Masoumi,Sophie C James,Julie A Tucker,Hauke Winkelmann,William Grey,Lora K Picton,Lucie Moss,Steven C Wilson,Nathanael A Caveney,Kevin M Jude,Cornelius Gati,Jacob Piehler,Ian S Hitchcock,K Christopher Garcia

Facile repurposing of peptide-MHC-restricted antibodies for cancer immunotherapy

肽-MHC 限制性抗体的简便再利用,用于癌症免疫治疗

Xinbo Yang #, Daisuke Nishimiya #, Sara Löchte, Kevin M Jude, Marta Borowska, Christina S Savvides, Michael Dougan, Leon Su, Xiang Zhao, Jacob Piehler, K Christopher Garcia

Plasma membrane topography governs the 3D dynamic localization of IgM B cell antigen receptor clusters

质膜拓扑结构控制 IgM B 细胞抗原受体簇的 3D 动态定位

Deniz Saltukoglu, Bugra Özdemir, Michael Holtmannspötter, Ralf Reski, Jacob Piehler, Rainer Kurre, Michael Reth

Organizing structural principles of the IL-17 ligand-receptor axis

IL-17 配体-受体轴的组织结构原理

Steven C Wilson #, Nathanael A Caveney #, Michelle Yen, Christoph Pollmann, Xinyu Xiang, Kevin M Jude, Maximillian Hafer, Naotaka Tsutsumi, Jacob Piehler, K Christopher Garcia

IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein

IL-2 在肿瘤的酸性 pH 环境中失活,因此可以设计出 pH 选择性突变蛋白

Silvia Gaggero, Jonathan Martinez-Fabregas, Adeline Cozzani, Paul K Fyfe, Malo Leprohon, Jie Yang, F Emil Thomasen, Hauke Winkelmann, Romain Magnez, Alberto G Conti, Stephan Wilmes, Elizabeth Pohler, Manuel van Gijsel Bonnello, Xavier Thuru, Bruno Quesnel, Fabrice Soncin, Jacob Piehler, Kresten Lind