日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Transcriptomic profiling of early synucleinopathy in rats induced with preformed fibrils

用预先形成的纤维诱导的大鼠早期突触核蛋白病的转录组分析

Joseph R Patterson ,Joseph Kochmanski ,Anna C Stoll ,Michael Kubik ,Christopher J Kemp ,Megan F Duffy ,Kajene Thompson ,Jacob W Howe ,Allyson Cole-Strauss ,Nathan C Kuhn ,Kathryn M Miller ,Seth Nelson ,Christopher U Onyekpe ,John S Beck ,Scott E Counts ,Alison I Bernstein ,Kathy Steece-Collier ,Kelvin C Luk ,Caryl E Sortwell

Neuroinflammatory gene expression profiles of reactive glia in the substantia nigra suggest a multidimensional immune response to alpha synuclein inclusions

黑质反应性胶质细胞的神经炎症基因表达谱表明,针对α-突触核蛋白包涵体的免疫反应是多维度的。

Anna C Stoll ,Christopher J Kemp ,Joseph R Patterson ,Jacob W Howe ,Kathy Steece-Collier ,Kelvin C Luk ,Caryl E Sortwell ,Matthew J Benskey

Beta2-adrenoreceptor agonist clenbuterol produces transient decreases in alpha-synuclein mRNA but no long-term reduction in protein

β2-肾上腺素受体激动剂克伦特罗会导致 α-突触核蛋白 mRNA 暂时减少,但不会导致蛋白质长期减少

Joseph R Patterson, Warren D Hirst, Jacob W Howe, Christopher P Russell, Allyson Cole-Strauss, Christopher J Kemp, Megan F Duffy, Jared Lamp, Andrew Umstead, Michael Kubik, Anna C Stoll, Irving E Vega, Kathy Steece-Collier, Yi Chen, Anne C Campbell, Catherine L Nezich, Kelly E Glajch, Caryl E Sortwe

Striatal Afferent BDNF Is Disrupted by Synucleinopathy and Partially Restored by STN DBS

纹状体传入 BDNF 因突触核蛋白病而中断,并通过 STN DBS 部分恢复

Kathryn M Miller, Joseph R Patterson, Joseph Kochmanski, Christopher J Kemp, Anna C Stoll, Christopher U Onyekpe, Allyson Cole-Strauss, Kathy Steece-Collier, Jacob W Howe, Kelvin C Luk, Caryl E Sortwell

Preformed fibrils generated from mouse alpha-synuclein produce more inclusion pathology in rats than fibrils generated from rat alpha-synuclein

与大鼠 α-突触核蛋白产生的原纤维相比,小鼠 α-突触核蛋白产生的预形成原纤维在大鼠体内产生更多的包涵体病理

Jacob W Howe, Caryl E Sortwell, Megan F Duffy, Christopher J Kemp, Christopher P Russell, Michael Kubik, Pooja Patel, Kelvin C Luk, Omar M A El-Agnaf, Joseph R Patterson

Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils

在由纹状体内 α-突触核蛋白预形成纤维引发的突触核蛋白病大鼠模型中,α-突触核蛋白内含物形成和黑质纹状体变性的时间过程和程度

Joseph R Patterson, Megan F Duffy, Christopher J Kemp, Jacob W Howe, Timothy J Collier, Anna C Stoll, Kathryn M Miller, Pooja Patel, Nathan Levine, Darren J Moore, Kelvin C Luk, Sheila M Fleming, Nicholas M Kanaan, Katrina L Paumier, Omar M A El-Agnaf, Caryl E Sortwell

Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

路易体样 α-突触核蛋白内含物在黑质变性之前引发反应性微胶质增生

Megan F Duffy, Timothy J Collier, Joseph R Patterson, Christopher J Kemp, Kelvin C Luk, Malú G Tansey, Katrina L Paumier, Nicholas M Kanaan, D Luke Fischer, Nicole K Polinski, Olivia L Barth, Jacob W Howe, Nishant N Vaikath, Nour K Majbour, Omar M A El-Agnaf, Caryl E Sortwell