日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

The unique role of nucS-mediated noncanonical mismatch repair in Mycobacterium tuberculosis resistance evolution

nucS介导的非经典错配修复在结核分枝杆菌耐药性进化中的独特作用

期刊:mBio
影响因子:4.7
doi:10.1128/mbio.03310-25
Martín-Blecua, Isabel; Sastre-Domínguez, Jorge; Valverde, José Ramón; García-Bravo, Pablo; Ruiz-Enamorado, Ángel; Prados-Rosales, Rafael; Das, Lahari; Jacobs, William R Jr; San Millán, Álvaro; Blázquez, Jesús; Gullón, Sonia
发表日期：2026
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Loss of the PPE71-esxX-esxY-PPE38 locus drives adaptive transcriptional responses and hypervirulence of Mycobacterium tuberculosis lineage 2

PPE71-esxX-esxY-PPE38基因座的缺失驱动结核分枝杆菌2系的适应性转录反应和高毒力

期刊:Science Advances
影响因子:12.5
doi:10.1126/sciadv.adw5194
Koleske, Benjamin; Schill, Courtney; Rajagopalan, Saranathan; Shee, Somnath; Martinez-Martinez, Yazmin B; Gupta, Manish; Shen, Jessica; Jacobs, William R Jr; Bishai, William R
发表日期：2025
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Loss of the ESX-5 secretion locus in Mycobacterium tuberculosis reshapes the mycomembrane and enhances ESX-1 substrate secretion

结核分枝杆菌中ESX-5分泌基因座的缺失会重塑分枝杆菌膜并增强ESX-1底物的分泌。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2509997122
Koleske, Benjamin; Rajagopalan, Saranathan; Schill, Courtney; Lun, Shichun; Vilchèze, Catherine; Das, Lahari; Gupta, Manish; Martinez-Martinez, Yazmin B; Bishai, William R; Jacobs, William R Jr
发表日期：2025
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Mycobacteriophage-mediated gene transfer enables in vitro drug screening and in vivo tracking of Mycobacterium leprae

利用分枝杆菌噬菌体介导的基因转移，可以进行体外药物筛选和麻风分枝杆菌的体内追踪。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2508271122
Das, Lahari; Chen, Bing; Rajagopalan, Saranathan; Vilcheze, Catherine; Mulholland, Claire V; Berney, Michael; Andrews, Patrick K; Edwards, Ashley; Lahiri, Ramanuj; Jacobs, William R Jr
发表日期：2025
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Luciferase reporter mycobacteriophage (TM4::GeNL) enables rapid assessment of drug susceptibilities and inducible macrolide resistance in Mycobacterium abscessus complex

荧光素酶报告基因分枝杆菌噬菌体（TM4::GeNL）能够快速评估脓肿分枝杆菌复合群的药物敏感性和诱导型大环内酯类耐药性。

期刊:Journal of Clinical Microbiology
影响因子:5.4
doi:10.1128/jcm.00841-25
Rajagopalan, Saranathan; Das, Lahari; Kohlerschmidt, Donna J; Rourke, Amy K; Shakir, Salika M; Larsen, Michelle H; O'Donnell, Max R; Szymczak, Wendy A; Escuyer, Vincent E; Thwe, Phyu M; Jacobs, William R Jr
IF
发表日期：2025
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Vitamin C potentiates the killing of Mycobacterium tuberculosis by bedaquiline through metabolic disruption

维生素C通过代谢干扰增强贝达喹啉对结核分枝杆菌的杀灭作用。

期刊:mBio
影响因子:4.7
doi:10.1128/mbio.01484-25
Vilchèze, Catherine; Rajagopalan, Saranathan; Kalluru, Raja Sab; Banaei, Niaz; Jacobs, William R Jr
代谢
发表日期：2025
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Engineered Mycobacteriophage TM4::GeNL Rapidly Determines Bedaquiline, Pretomanid, Linezolid, Rifampicin, and Clofazimine Sensitivity in Mycobacterium tuberculosis Clinical Isolates

工程化分枝杆菌噬菌体TM4::GeNL可快速测定结核分枝杆菌临床分离株对贝达喹啉、普瑞托马尼、利奈唑胺、利福平和氯法齐明的敏感性

期刊:Journal of Infectious Diseases
影响因子:4.5
doi:10.1093/infdis/jiae438
Rajagopalan, Saranathan; Rourke, Amy K; Asare, Emmanuel; Kohlerschmidt, Donna J; Das, Lahari; Ngema, Senamile L; Mulholland, Claire V; Vilchèze, Catherine; Mahalingam, Vaishnavi; Moodley, Sashen; Truebody, Barry; Mackenzie, Jared; Steyn, Adrie J C; Perumal, Rubeshan; Berney, Michael; Larsen, Michelle H; O'Donnell, Max R; Escuyer, Vincent E; Jacobs, William R Jr
发表日期：2025
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Propionate prevents loss of the PDIM virulence lipid in Mycobacterium tuberculosis

丙酸盐可防止结核分枝杆菌毒力脂质PDIM的丢失

期刊:Nature Microbiology
影响因子:19.4
doi:10.1038/s41564-024-01697-8
Mulholland, Claire V; Wiggins, Thomas J; Cui, Jinhua; Vilchèze, Catherine; Rajagopalan, Saranathan; Shultis, Michael W; Reyes-Fernández, Esmeralda Z; Jacobs, William R Jr; Berney, Michael
发表日期：2024
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Loss-of-function mutations in ndh do not confer delamanid, ethionamide, isoniazid, or pretomanid resistance in Mycobacterium tuberculosis

ndh基因的功能缺失突变不会使结核分枝杆菌对德拉马尼、乙硫异烟胺、异烟肼或普托马尼产生耐药性。

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/aac.01096-23
Pandey, Sushil; Vilchèze, Catherine; Werngren, Jim; Bainomugisa, Arnold; Mansjö, Mikael; Groenheit, Ramona; Miotto, Paolo; Cirillo, Daniela M; Coulter, Christopher; Baulard, Alain R; Schön, Thomas; Jacobs, William R Jr; Djaout, Kamel; Köser, Claudio U
发表日期：2024
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The SapM phosphatase can arrest phagosome maturation in an ESX-1 independent manner in Mycobacterium tuberculosis and BCG

在结核分枝杆菌和卡介苗中，SapM磷酸酶可以以一种不依赖于ESX-1的方式阻滞吞噬体的成熟。

期刊:Infection and Immunity
影响因子:2.8
doi:10.1128/iai.00217-24
Xander, Christian; Rajagopalan, Saranathan; Jacobs, William R Jr; Braunstein, Miriam
发表日期：2024
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