日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting dCas9-SunTag to a Susceptibility Gene Promoter Is Sufficient for CRISPR Interference

将 dCas9-SunTag 靶向易感基因启动子足以进行 CRISPR 干扰

Lin, Zuh-Jyh Daniel; Hernandez, Gabriela L; Stanton, Myia K; Zheng, Xingguo; Gilbert, Kerrigan B; Veley, Kira M; Jensen, Greg; Yoder, Marisa; Feng, Suhua; Ghoshal, Basudev; Gardiner, Jason; Wang, Ming; Jacobsen, Steven E; Carrington, James C; Bart, Rebecca S

Efficient transgene-free multiplexed germline editing via viral delivery of an engineered TnpB

通过病毒载体递送工程化TnpB,实现高效的无转基因多重种系编辑

Weiss, Trevor; Kamalu, Maris; Shi, Honglue; Wirnowski, Gabriel; Ingelsson, Alice; Amerasekera, Jasmine; Vohra, Kamakshi; Trinidad, Marena I; Li, Zheng; Freitas, Emily; Steinmetz, Noah; Ambrose, Charlie; Chen, Kerry; Doudna, Jennifer A; Jacobsen, Steven E

Stepwise DNA unwinding gates TnpB genome-editing activity

逐步DNA解旋调控TnpB基因组编辑活性

Zhou, Zehan; Saffarian-Deemyad, Iren; Shi, Honglue; Weiss, Trevor; Ur-Rehman, Muhammad Moez; Vohra, Kamakshi; Skopintsev, Petr; Yoon, Peter H; Trinidad, Marena I; Langeberg, Conner J; Kamalu, Maris; Amerasekera, Jasmine; Doherty, Erin E; Aris, Kevin D P; Al-Sayyad, Noor; Thornton, Brittney W; Weissman, Rachel F; Wasko, Kevin M; Esain-Garcia, Isabel; DeTurk, Evan C; Savage, David F; Jacobsen, Steven E; Bryant, Zev; Doudna, Jennifer A

Multiple redundant mechanisms account for the majority of gene silencing downstream of DNA methylation

DNA甲基化下游的大部分基因沉默是由多种冗余机制造成的。

Wang, Shuya; Wu, Zhongshou; Li, Zheng; Movilli, Andrea; He, Li; Zhou, Yuxing; Lin, Evan K; Chuang, Russell; Thiri, Wai Wai; Convery, Sean; Feng, Suhua; Weigel, Detlef; Jacobsen, Steven E

REM transcription factors and GDE1 shape the DNA methylation landscape through the recruitment of RNA polymerase IV transcription complexes.

REM 转录因子和 GDE1 通过募集 RNA 聚合酶 IV 转录复合物来塑造 DNA 甲基化图谱

Wu Zhongshou, Xue Yan, Wang Shuya, Shih Yuan-Hsin, Zhong Zhenhui, Feng Suhua, Draper Jonathan, Lu Allen, Hoeke Carsten A, Sha Jihui, Li Lu, Wohlschlegel James, Wu Keqiang, Jacobsen Steven E

Viral delivery of an RNA-guided genome editor for transgene-free germline editing in Arabidopsis

利用病毒载体递送RNA引导的基因组编辑器,在拟南芥中进行无转基因种系编辑

Weiss, Trevor; Kamalu, Maris; Shi, Honglue; Li, Zheng; Amerasekera, Jasmine; Zhong, Zhenhui; Adler, Benjamin A; Song, Michelle M; Vohra, Kamakshi; Wirnowski, Gabriel; Chitkara, Sidharth; Ambrose, Charlie; Steinmetz, Noah; Sridharan, Ananya; Sahagun, Diego; Banfield, Jillian F; Doudna, Jennifer A; Jacobsen, Steven E

Regulation of MORC-1 is key to the CSR-1-mediated germline gene licensing mechanism in C. elegans.

MORC-1 的调控是秀丽隐杆线虫中 CSR-1 介导的种系基因许可机制的关键

Kirshner Jessica A, Picard Colette L, Weiser Natasha E, Mehta Nicita, Feng Suhua, Murphy Victoria N, Vakhnovetsky Anna, Alessi Amelia F, Xiao Connie, Inoki Kai, El Mouridi Sonia, Frøkjær-Jensen Christian, Jacobsen Steven E, Kim John K

CDCA7 facilitates MET1-mediated CG DNA methylation maintenance in centromeric heterochromatin via linker histone H1

CDCA7 通过连接组蛋白 H1 促进着丝粒异染色质中 MET1 介导的 CG DNA 甲基化维持。

Wang, Shuya; Li, Tong; Naish, Matthew; Chuang, Russell; Lin, Evan K; Fonkalsrud, Christian; He, Yan; Feng, Suhua; Henderson, Ian R; Jacobsen, Steven E

Medullary Thyroid Carcinoma and Clinical Outcomes in Heterozygous Carriers of the RET K666N Germline Pathogenic Variant

髓样甲状腺癌及RET K666N种系致病变异杂合子携带者的临床结局

Yip, Allison T; Kim, Teresa H; Peluso, Esther M; Jacobsen, Steven E; Yeh, Michael W; Lechner, Melissa G

Structure and evolution-guided design of minimal RNA-guided nucleases

基于结构和进化的最小RNA引导核酸酶设计

Skopintsev, Petr; Esain-Garcia, Isabel; DeTurk, Evan C; Yoon, Peter H; Zhou, Zehan; Weiss, Trevor; Kamalu, Maris; Chamraj, Ajit; Loi, Kenneth J; Langeberg, Conner J; Boger, Ron; Nisonoff, Hunter; Karp, Hannah M; Chen, LinXing; Shi, Honglue; Vohra, Kamakshi; Banfield, Jillian F; Cate, Jamie H D; Jacobsen, Steven E; Doudna, Jennifer A