日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Transformation of a Potent C9-Substituted Phenylmorphan into MOR Partial Agonists with Improvement of Metabolic Stability: An In Vitro, In Vivo, and In Silico Study

将一种强效的C9取代苯基吗啡烷转化为MOR部分激动剂并提高其代谢稳定性：一项体外、体内和计算机模拟研究

期刊:ACS Chemical Neuroscience
影响因子:3.9
doi:10.1021/acschemneuro.5c00211
Hernandez, Delmis E; Luo, Dan; Prisinzano, Thomas E; Negus, S Stevens; Nassehi, Nima; Selley, Dana E; Shah, Pranav; Kato, Rintaro; Xu, Xin; Talarico, Carmine; Graziani, Davide; Beccari, Andrea R; Jacobson, Arthur E; Rice, Kenner C; Sulima, Agnieszka
代谢
发表日期：2025
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Safety and Toxicology Profile of TT-6-AmHap Heroin Conjugate Vaccine

TT-6-AmHap海洛因结合疫苗的安全性和毒理学概况

期刊:Vaccines
影响因子:3.4
doi:10.3390/vaccines13080792
Komla, Essie; Abucayon, Erwin G; Godin, C Steven; Sulima, Agnieszka; Jacobson, Arthur E; Rice, Kenner C; Matyas, Gary R
发表日期：2025
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Enhancing Protective Antibodies against Opioids through Antigen Display on Virus-like Particles

通过在病毒样颗粒上展示抗原来增强针对阿片类药物的保护性抗体

期刊:Bioconjugate Chemistry
影响因子:3.9
doi:10.1021/acs.bioconjchem.3c00415
Shafieichaharberoud, Fatemeh; Lang, Shuyao; Whalen, Connor; Rivera Quiles, Cristina; Purcell, Lillie; Talbot, Cameron; Wang, Pengfei; Norton, Elizabeth B; Mazei-Robison, Michelle; Sulima, Agnieszka; Jacobson, Arthur E; Rice, Kenner C; Matyas, Gary R; Huang, Xuefei
微生物学
发表日期：2024
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Low-Efficacy Mu Opioid Agonists as Candidate Analgesics: Effects of Novel C-9 Substituted Phenylmorphans on Pain-Depressed Behavior in Mice.

低效μ阿片受体激动剂作为候选镇痛药：新型C-9取代苯基吗啡烷对小鼠疼痛抑制行为的影响

期刊:Journal of Pharmacology and Experimental Therapeutics
影响因子:3.8
doi:10.1124/jpet.124.002153
Santos Edna J, Akbarali Hamid I, Bow Eric W, Chambers Dana R, Gutman Eugene S, Jacobson Arthur E, Kang Minho, Lee Young K, Lutz Joshua A, Rice Kenner C, Sulima Agnieszka, Negus S Stevens
信号转导
发表日期：2024
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A MOR Antagonist with High Potency and Antagonist Efficacy among Diastereomeric C9-Alkyl-Substituted N-Phenethyl-5-(3-hydroxy)phenylmorphans

在非对映异构体 C9-烷基取代的 N-苯乙基-5-(3-羟基)苯基吗啡烷中，一种具有高活性和拮抗功效的 MOR 拮抗剂

期刊:Molecules
影响因子:4.6
doi:10.3390/molecules28145411
Chambers, Dana R; Sulima, Agnieszka; Luo, Dan; Prisinzano, Thomas E; Jacobson, Arthur E; Rice, Kenner C
发表日期：2023
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Discovery of a Potent Highly Biased MOR Partial Agonist among Diastereomeric C9-Hydroxyalkyl-5-phenylmorphans

在非对映异构体 C9-羟烷基-5-苯基吗啡烷中发现一种强效高偏向性 MOR 部分激动剂

期刊:Molecules
影响因子:4.6
doi:10.3390/molecules28124795
Lutz, Joshua A; Sulima, Agnieszka; Gutman, Eugene S; Bow, Eric W; Luo, Dan; Kaska, Sophia; Prisinzano, Thomas E; Paronis, Carol A; Bergman, Jack; Imler, Gregory H; Kerr, Andrew T; Jacobson, Arthur E; Rice, Kenner C
发表日期：2023
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A Journey through Diastereomeric Space: The Design, Synthesis, In Vitro and In Vivo Pharmacological Activity, and Molecular Modeling of Novel Potent Diastereomeric MOR Agonists and Antagonists

非对映异构体空间之旅：新型高效非对映异构体MOR激动剂和拮抗剂的设计、合成、体外和体内药理活性及分子建模

期刊:Molecules
影响因子:4.6
doi:10.3390/molecules27196455
Chambers, Dana R; Sulima, Agnieszka; Luo, Dan; Prisinzano, Thomas E; Goldberg, Alexander; Xie, Bing; Shi, Lei; Paronis, Carol A; Bergman, Jack; Nassehi, Nima; Selley, Dana E; Imler, Gregory H; Jacobson, Arthur E; Rice, Kenner C
发表日期：2022
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Bivalent Conjugate Vaccine Induces Dual Immunogenic Response That Attenuates Heroin and Fentanyl Effects in Mice

二价结合疫苗诱导双重免疫反应，可减轻小鼠体内海洛因和芬太尼的作用

期刊:Bioconjugate Chemistry
影响因子:3.9
doi:10.1021/acs.bioconjchem.1c00179
Barrientos, Rodell C; Whalen, Connor; Torres, Oscar B; Sulima, Agnieszka; Bow, Eric W; Komla, Essie; Beck, Zoltan; Jacobson, Arthur E; Rice, Kenner C; Matyas, Gary R
免疫/内分泌
发表日期：2021
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Synthesis and immunological effects of C14-linked 4,5-epoxymorphinan analogues as novel heroin vaccine haptens

合成C14连接的4,5-环氧吗啡烷类似物及其作为新型海洛因疫苗半抗原的免疫学效应

期刊:RSC Chemical Biology
影响因子:3.1
doi:10.1039/d1cb00029b
Gutman, Eugene S; Irvin, Thomas C; Morgan, J Brian; Barrientos, Rodell C; Torres, Oscar B; Beck, Zoltan; Matyas, Gary R; Jacobson, Arthur E; Rice, Kenner C
免疫/内分泌
发表日期：2021
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Novel Vaccine That Blunts Fentanyl Effects and Sequesters Ultrapotent Fentanyl Analogues

一种新型疫苗可减轻芬太尼的作用并隔离超强效芬太尼类似物

期刊:Molecular Pharmaceutics
影响因子:4.5
doi:10.1021/acs.molpharmaceut.0c00497
Barrientos, Rodell C; Bow, Eric W; Whalen, Connor; Torres, Oscar B; Sulima, Agnieszka; Beck, Zoltan; Jacobson, Arthur E; Rice, Kenner C; Matyas, Gary R
发表日期：2020
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