日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The diabetes-associated K(+) channel TALK-2 controls human beta cell endoplasmic reticulum Ca(2+) handling, which promotes basal insulin release and limits glucose-stimulated insulin secretion

与糖尿病相关的K(+)通道TALK-2控制着人类β细胞内质网Ca(2+)的处理,从而促进基础胰岛素释放并限制葡萄糖刺激的胰岛素分泌。

Dobson, Jordyn R; Dadi, Prasanna K; Dickerson, Matthew T; Nakhe, Arya Y; Behera, Soma; Gibson, Shannon E; Peachee, Spencer J; Piron, Anthony; Cnop, Miriam; Jacobson, David A

Paracrine Hormonal Signals From Islet α-Cells Regulate Microtubule Dynamics in β-Cells to Promote Insulin Secretion in Mouse and Human Islets

胰岛α细胞旁分泌激素信号调节β细胞微管动力学,从而促进小鼠和人胰岛的胰岛素分泌。

Ho, Kung-Hsien; Barmaver, Syed N; Gibson, Shannon E; Hu, Ruiying; Yagan, Mahircan; Ahmed, Hamida K; Balamurugan, Appakalai N; Jacobson, David A; Kaverina, Irina; Gu, Guoqiang

Glycolytic activation of β-cell Na(+)/K(+)-ATPases containing β1-subunits accelerates Na(+) extrusion, prolonging the duration of Ca(2+) oscillations but decreasing insulin secretion

β细胞中含有β1亚基的Na(+)/K(+)-ATP酶的糖酵解激活可加速Na(+)外排,延长Ca(2+)振荡的持续时间,但会降低胰岛素分泌。

Dickerson, Matthew T; Dadi, Prasanna K; McDevitt, Reagan P; Dobson, Jordyn R; Behera, Soma; Peachee, Spencer J; Gibson, Shannon E; Wangmo, Tenzin; Jacobson, David A

Sarco/Endoplasmic Reticulum Ca(2+) ATPase Activation Shifts Cardiac Fuel Preference Without Impairing Cardiac Function in Obese Mice.

肌浆网/内质网 Ca(2+) ATPase 激活可改变肥胖小鼠的心脏燃料偏好,而不会损害心脏功能。

Banerjee Deveena R, Hasenour Clinton M, Rahim Mohsin, Bednarski Tomasz K, Doran Amanda C, Jacobson David A, Young Jamey D

Pancreatic islet β-cell subtypes are derived from biochemically-distinct and nutritionally-regulated islet progenitors

胰岛β细胞亚型来源于生化特性不同且受营养调控的胰岛祖细胞。

Brown, Monica E; Miranda, Verda E; Nevills, Simone; Hu, Ruiying; Dadi, Prasanna K; Simmons, Alan J; Xu, Yanwen; Yang, Yilin; Yagan, Mahircan; Najam, Sadia; Sampson, Leesa L; Magnuson, Mark A; Jacobson, David A; Lau, Ken S; Hodges, Emily; Gu, Guoqiang

Atf4 Protects Islet β-Cell Identity and Function Under Acute Glucose-Induced Stress but Promotes β-Cell Failure in the Presence of Free Fatty Acid

在急性葡萄糖诱导应激下,ATF4 可保护胰岛β细胞的特性和功能,但在游离脂肪酸存在的情况下,ATF4 会促进β细胞衰竭。

Yagan, Mahircan; Najam, Sadia; Hu, Ruiying; Wang, Yu; Dickerson, Mathew T; Dadi, Prasanna K; Xu, Yanwen; Simmons, Alan J; Stein, Roland; Adams, Christopher M; Jacobson, David A; Lau, Ken S; Liu, Qi; Gu, Guoqiang

Dynamic Ca2+-Dependent Transcription Links Metabolic Stress to Impaired β-Cell Identity.

动态 Ca2+ 依赖性转录将代谢压力与 β 细胞身份受损联系起来

Osipovich Anna B, Dickerson Matthew T, Cartailler Jean-Philippe, Shrestha Shristi, Wright Nicole M, Jacobson David A, Magnuson Mark A

CHD3 and CHD4 coordinate gene expression programs to maintain β-cell function and identity in vivo.

CHD3 和 CHD4 协调基因表达程序,以维持体内 β 细胞的功能和特性。

Kanojia Sukrati, Sharma Avinil Das, George Rajani M, Taylor Abigail G, Wu Wenting, Dickerson Matthew T, Peachee Spencer J, Dadi Prasanna K, Kacher Alexander, Devaguptapu Harshith, Davidson Rebecca K, Nag Snehasish, Huter Kayla, Osmulski Meredith, Sandoval Kassandra, Jacobson David A, Spaeth Jason M

Disrupted Endoplasmic Reticulum Ca(2+) Handling: A Harβinger of β-Cell Failure

内质网钙离子处理紊乱:β细胞功能衰竭的先兆

Dobson, Jordyn R; Jacobson, David A

IP(3)Rs puff along: A SNAPpy dance with IP(3) and Ca(2)

IP(3)Rs 一起飘动:与 IP(3) 和 Ca(2) 的 SNAPpy 舞蹈

Nakhe, Arya Y; Jacobson, David A