日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Molecular engineering of lysosome-based degraders unveils a rapidly expanding therapeutic strategy

溶酶体降解剂的分子工程改造揭示了一种快速发展的治疗策略

Rivault, Adele; Dussart-Gautheret, Jade; Benhida, Rachid; Martin, Anthony R; Auberger, Patrick; Jacquel, Arnaud; Robert, Guillaume

Dual targeting of GPX4 and TXNRD1 triggers eradication of AML cells through induction of apoptosis and ferroptosis

GPX4 和 TXNRD1 的双重靶向作用可通过诱导细胞凋亡和铁死亡来清除 AML 细胞。

Favreau, Cécile; Bourgoin, Maxence; Savy, Coline; Botton, Thomas; Bailly, Sarah; Granger, Florence; Birck, Catherine; Zerhouni, Marwa; Kerreneur, Emeline; Rivault, Adele; Vigroux, Alban; Dussart-Gautheret, Jade; Arcangeli, Marie-Laure; Poterszman, Arnaud; Cluzeau, Thomas; Rocchi, Stephane; Jacquel, Arnaud; Benhida, Rachid; Auberger, Patrick; Martin, Anthony R; Robert, Guillaume

Enhanced efficacy of a specific HDAC3 inhibitor in combination with 5-azacitidine against diffuse large B-cell lymphoma

特异性 HDAC3 抑制剂与 5-氮杂胞苷联合治疗弥漫性大 B 细胞淋巴瘤可增强疗效

Calaud, Calixte; Serrano-Lopez, Emilio M; Cluse, Leonie A; Todorovski, Izabela; Mardivirin, Thomas; Teater, Matt R; Maarad, Abdelillah; Tawfic, Noura; Fraser, Peter J; Guiraud, Killian; Dupont, Coralie; Menigot, Corinne; Sant'Anna-Silva, Ana Carolina B; Yoannidis, David; Semple, Tim; Kerreneur, Emeline; Rocchi, Stéphane; Jacquel, Arnaud; Melnick, Ari M; Johnstone, Ricky W; Dominguez, Pilar M

VEXAS, Chediak-Higashi syndrome and Danon disease: myeloid cell endo-lysosomal pathway dysfunction as a common denominator?

VEXAS、Chediak-Higashi综合征和Danon病:髓系细胞内溶酶体途径功能障碍是其共同特征吗?

Savy, Coline; Bourgoin, Maxence; Cluzeau, Thomas; Jacquel, Arnaud; Robert, Guillaume; Auberger, Patrick

AML patient blasts exhibit polarization defects upon interaction with bone marrow stromal cells.

急性髓系白血病患者的原始细胞在与骨髓基质细胞相互作用时表现出极化缺陷

Saadallah Khansa, Vianay Benoît, Bonnemay Louise, Pasquer Hélène, Kelly Lois, Mathis Stéphanie, Culeux Cécile, Marie Raphael, Meslin Paul Arthur, Fodil Sofiane, Chaintreuil Paul, Kerreneur Emeline, Jacquel Arnaud, Raffoux Emmanuel, Nizard Rémy, Lobry Camille, Blanchoin Laurent, Benajiba Lina, Théry Manuel

Dasatinib overcomes AML cells resistant to BCL2 inhibition by degrading MCL1

达沙替尼通过降解MCL1来克服对BCL2抑制剂耐药的AML细胞。

Garciaz, Sylvain; Montersino, Camille; Bourgoin, Maxence; Jacquel, Arnaud; Castellano, Rémy; Guille, Arnaud; Chaffanet, Max; Bertucci, François; Hospital, Marie-Anne; Adélaïde, José; Auberger, Patrick; Vey, Norbert; Collette, Yves

CSF1R regulates monocyte subset differentiation and intracellular metabolism

CSF1R 调控单核细胞亚群分化和细胞内代谢

Gallerand, Alexandre; Merlin, Johanna; Caillot, Zakariya; Delaby, Chloé; Bord, Elisa; Han, Jichang; Dolfi, Bastien; Castiglione, Alexia; Grenet, Sacha; Franceschini, Maxime; Jarretou, Gisèle; Zair, Fairouz N; Boré, Evy; Tuffin, Florian; Dombrowicz, David; Guinamard, Rodolphe R; Randolph, Gwendalyn J; Bertola, Adeline; Auberger, Patrick; Jacquel, Arnaud; Hume, David A; Williams, Jesse W; Bajénoff, Marc; Neels, Jaap G; Ivanov, Stoyan

Emerging role of glutathione peroxidase 4 in myeloid cell lineage development and acute myeloid leukemia

谷胱甘肽过氧化物酶 4 在髓系细胞谱系发育和急性髓系白血病中的新兴作用

Auberger, Patrick; Favreau, Cécile; Savy, Coline; Jacquel, Arnaud; Robert, Guillaume

Improving nutritional status after allogeneic stem cell transplantation: results of phase 2 ALLONUT clinical trial

改善异基因造血干细胞移植后的营养状况:ALLONUT II期临床试验结果

Estran, Sophie; Loschi, Michael; Benachour, Sami; Soldati, Alizée; Chiche, Edmond; Sammut, Rinzine; Robert, Guillaume; Jacquel, Arnaud; Chibois, Jacques; Schneider, Stephane; Cluzeau, Thomas

High caspase 3 and vulnerability to dual BCL2 family inhibition define ETO2::GLIS2 pediatric leukemia

高水平的 caspase 3 和对双重 BCL2 家族抑制剂的敏感性是 ETO2::GLIS2 儿童白血病的特征。

Aid, Zakia; Robert, Elie; Lopez, Cécile K; Bourgoin, Maxence; Boudia, Fabien; Le Mene, Melchior; Riviere, Julie; Baille, Marie; Benbarche, Salima; Renou, Laurent; Fagnan, Alexandre; Thirant, Cécile; Federici, Laetitia; Touchard, Laure; Lecluse, Yann; Jetten, Anton; Geoerger, Birgit; Lapillonne, Hélène; Solary, Eric; Gaudry, Muriel; Meshinchi, Soheil; Pflumio, Françoise; Auberger, Patrick; Lobry, Camille; Petit, Arnaud; Jacquel, Arnaud; Mercher, Thomas