日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Age-specific and compartment-dependent changes in mitochondrial homeostasis and cytoplasmic viscosity in mouse peripheral neurons

小鼠外周神经元线粒体稳态和细胞质粘度随年龄和区域变化

James N Sleigh, Francesca Mattedi, Sandy Richter, Emily Annuario, Kristal Ng, I Emilie Steinmark, Iveta Ivanova, István L Darabán, Parth P Joshi, Elena R Rhymes, Shirwa Awale, Gokhan Yahioglu, Jacqueline C Mitchell, Klaus Suhling, Giampietro Schiavo, Alessio Vagnoni

Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca2+ and synaptic defects

刺激 VAPB-PTPIP51 ER-线粒体束缚可纠正 FTD/ALS 突变体 TDP43 关联的 Ca2+ 和突触缺陷

Andrea Markovinovic #, Sandra M Martín-Guerrero #, Gábor M Mórotz, Shaakir Salam, Patricia Gomez-Suaga, Sebastien Paillusson, Jenny Greig, Younbok Lee, Jacqueline C Mitchell, Wendy Noble, Christopher C J Miller

Disruption of ER-mitochondria tethering and signalling in C9orf72-associated amyotrophic lateral sclerosis and frontotemporal dementia

C9orf72 相关肌萎缩侧索硬化症和额颞叶痴呆症中内质网线粒体连接和信号传导中断

Patricia Gomez-Suaga, Gábor M Mórotz, Andrea Markovinovic, Sandra M Martín-Guerrero, Elisavet Preza, Natalia Arias, Keith Mayl, Afra Aabdien, Vesela Gesheva, Agnes Nishimura, Ambra Annibali, Younbok Lee, Jacqueline C Mitchell, Selina Wray, Christopher Shaw, Wendy Noble, Christopher C J Miller

Heterozygous expression of the Alzheimer's disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses

阿尔茨海默病保护性 PLCγ2 P522R 变体的杂合表达可增强 Aβ 清除,同时保留突触

Shiden Solomon, Nirmal Kumar Sampathkumar, Ivo Carre, Mrityunjoy Mondal, George Chennell, Anthony C Vernon, Marc-David Ruepp, Jacqueline C Mitchell

RNA-Seq is not required to determine stable reference genes for qPCR normalization

无需 RNA-Seq 即可确定 qPCR 标准化的稳定参考基因

Nirmal Kumar Sampathkumar, Venkat Krishnan Sundaram, Prakroothi S Danthi, Rasha Barakat, Shiden Solomon, Mrityunjoy Mondal, Ivo Carre, Tatiana El Jalkh, Aïda Padilla-Ferrer, Julien Grenier, Charbel Massaad, Jacqueline C Mitchell

Identification of a novel interaction of FUS and syntaphilin may explain synaptic and mitochondrial abnormalities caused by ALS mutations

鉴定出 FUS 和 syntaphilin 之间的新型相互作用可能可以解释 ALS 突变引起的突触和线粒体异常

Shaakir Salam, Sara Tacconelli, Bradley N Smith, Jacqueline C Mitchell, Elizabeth Glennon, Nikolas Nikolaou, Corinne Houart, Caroline Vance

Mitochondrial abnormalities and disruption of the neuromuscular junction precede the clinical phenotype and motor neuron loss in hFUSWT transgenic mice

在 hFUSWT 转基因小鼠中,线粒体异常和神经肌肉接头破坏先于临床表型和运动神经元丢失

Eva So, Jacqueline C Mitchell, Caroline Memmi, George Chennell, Gema Vizcay-Barrena, Leanne Allison, Christopher E Shaw, Caroline Vance

4-Year Changes in Sex Hormones, Sexual Functioning, and Psychosocial Status in Women Who Underwent Bariatric Surgery

接受减肥手术的女性4年后性激素、性功能和心理社会状况的变化

Sarwer, David B; Wadden, Thomas A; Spitzer, Jacqueline C; Mitchell, James E; Lancaster, Kathy; Courcoulas, Anita; Gourash, William; Rosen, Raymond C; Christian, Nicholas J

Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate

苯丁酸可挽救小鼠中人脑源性 tau 片段低水平表达引起的 tau 病

Marie K Bondulich, Tong Guo, Christopher Meehan, John Manion, Teresa Rodriguez Martin, Jacqueline C Mitchell, Tibor Hortobagyi, Natalia Yankova, Virginie Stygelbout, Jean-Pierre Brion, Wendy Noble, Diane P Hanger

ALS/FTD-associated FUS activates GSK-3β to disrupt the VAPB-PTPIP51 interaction and ER-mitochondria associations

ALS/FTD 相关的 FUS 激活 GSK-3β 以破坏 VAPB-PTPIP51 相互作用和 ER-线粒体关联

Radu Stoica, Sébastien Paillusson, Patricia Gomez-Suaga, Jacqueline C Mitchell, Dawn Hw Lau, Emma H Gray, Rosa M Sancho, Gema Vizcay-Barrena, Kurt J De Vos, Christopher E Shaw, Diane P Hanger, Wendy Noble, Christopher Cj Miller