日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

ADA2-deficient cells exhibit increased levels of cell death and metabolic disturbances.

ADA2 缺陷细胞表现出细胞死亡水平升高和代谢紊乱。

Ehlers Lisa, Wouters Marjon, Pillay Bethany, Delafontaine Selket, Bucciol Giorgia, Baggio Marco, Dzhus Mariia, Hombrouck Anneleen, Damerau Alexandra, De Somer Lien, Schrijvers Rik, Vanderschueren Steven, Jacquemyn Maarten, Kallinich Tilmann, Daelemans Dirk, Ghesquière Bart, Agostinis Patrizia, Moens Leen, Meyts Isabelle

Inhibition of lysosomal degradation increases expression of mutant ADA2 in DADA2 monocytes

抑制溶酶体降解会增加DADA2单核细胞中突变型ADA2的表达。

Ehlers, Lisa; Wouters, Marjon; Pillay, Bethany; Delafontaine, Selket; Dzhus, Mariia; Baggio, Marco; Niehues, Tim; Dückers, Gregor; Sevenants, Lieve; Casteels, Kristina; De Somer, Lien; Schrijvers, Rik; Vanderschueren, Steven; Jacquemyn, Maarten; Daelemans, Dirk; Hombrouck, Anneleen; Chambers, Eugene P; Tousseyn, Thomas; Bucciol, Giorgia; Agostinis, Patrizia; Moens, Leen; Meyts, Isabelle

Human and viral chemokines differentially modulate G protein signaling, β-arrestin recruitment and chemotaxis mediated by the viral G protein-coupled receptor ORF74.

人类和病毒趋化因子对病毒 G 蛋白偶联受体 ORF74 介导的 G 蛋白信号传导、β-arrestin 募集和趋化作用具有不同的调节作用。

Kong Qianqian, Van Bosstraeten Brent, Jacquemyn Maarten, Daelemans Dirk, De Jonghe Steven, Schols Dominique, Van Loy Tom

A guanidine-based coronavirus replication inhibitor which targets the nsp15 endoribonuclease and selects for interferon-susceptible mutant viruses

一种基于胍的冠状病毒复制抑制剂,靶向nsp15核糖核酸内切酶,并筛选出对干扰素敏感的突变病毒。

Van Loy, Benjamin; Pujol, Eugènia; Kamata, Kenichi; Lee, Xiao Yin; Bakirtzoglou, Nikolai; Van Berwaer, Ria; Vandeput, Julie; Mestdagh, Cato; Persoons, Leentje; De Wijngaert, Brent; Goovaerts, Quinten; Noppen, Sam; Jacquemyn, Maarten; Ahmadzadeh, Kourosh; Bernaerts, Eline; Martín-López, Juan; Escriche, Celia; Vanmechelen, Bert; Krasniqi, Besir; Singh, Abhimanyu K; Daelemans, Dirk; Maes, Piet; Matthys, Patrick; Dehaen, Wim; Rozenski, Jef; Das, Kalyan; Voet, Arnout; Vázquez, Santiago; Naesens, Lieve; Stevaert, Annelies

SINE compounds activate exportin-1 degradation via an allosteric mechanism

SINE化合物通过变构机制激活输出蛋白-1的降解。

Wing, Casey Elizabeth; Fung, Ho Yee Joyce; Kwanten, Bert; Cagatay, Tolga; Niesman, Ashley B; Jacquemyn, Maarten; Gharghabi, Mehdi; Permentier, Brecht; Shakya, Binita; Nandi, Rhituparna; Ready, Joseph M; Kashyap, Trinayan; Shacham, Sharon; Landesman, Yosef; Lapalombella, Rosa; Daelemans, Dirk; Chook, Yuh Min

CRISPR-Cas9 recognition of enzymatically synthesized base-modified nucleic acids

CRISPR-Cas9识别酶促合成的碱基修饰核酸

Yang, Hui; Eremeeva, Elena; Abramov, Mikhail; Jacquemyn, Maarten; Groaz, Elisabetta; Daelemans, Dirk; Herdewijn, Piet

CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity

利用 CRISPR/Cas9 技术在人类 iPSC 衍生的皮层神经元中进行筛选,发现 NEK6 是 C9orf72 poly(PR) 毒性的新型疾病修饰因子。

Guo, Wenting; Wang, Haibo; Kumar Tharkeshwar, Arun; Couthouis, Julien; Braems, Elke; Masrori, Pegah; Van Schoor, Evelien; Fan, Yannan; Ahuja, Karan; Moisse, Matthieu; Jacquemyn, Maarten; Furtado Madeiro da Costa, Rodrigo; Gajjar, Madhavsai; Balusu, Sriram; Tricot, Tine; Fumagalli, Laura; Hersmus, Nicole; Janky, Rekin's; Impens, Francis; Vanden Berghe, Pieter; Ho, Ritchie; Thal, Dietmar Rudolf; Vandenberghe, Rik; Hegde, Muralidhar L; Chandran, Siddharthan; De Strooper, Bart; Daelemans, Dirk; Van Damme, Philip; Van Den Bosch, Ludo; Verfaillie, Catherine

XPO1 inhibitors represent a novel therapeutic option in Adult T-cell Leukemia, triggering p53-mediated caspase-dependent apoptosis

XPO1抑制剂代表了成人T细胞白血病的一种新型治疗选择,它能触发p53介导的caspase依赖性细胞凋亡。

Boons, Eline; Nogueira, Tatiane C; Dierckx, Tim; Menezes, Soraya Maria; Jacquemyn, Maarten; Tamir, Sharon; Landesman, Yosef; Farré, Lourdes; Bittencourt, Achiléa; Kataoka, Keisuke; Ogawa, Seishi; Snoeck, Robert; Andrei, Graciela; Van Weyenbergh, Johan; Daelemans, Dirk

ATXN1 repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization.

ATXN1 重复扩增会增加患肌萎缩侧索硬化症的风险,并导致 TDP-43 错误定位

Tazelaar Gijs H P, Boeynaems Steven, De Decker Mathias, van Vugt Joke J F A, Kool Lindy, Goedee H Stephan, McLaughlin Russell L, Sproviero William, Iacoangeli Alfredo, Moisse Matthieu, Jacquemyn Maarten, Daelemans Dirk, Dekker Annelot M, van der Spek Rick A, Westeneng Henk-Jan, Kenna Kevin P, Assialioui Abdelilah, Da Silva Nica, Povedano Mónica, Pardina Jesus S Mora, Hardiman Orla, Salachas François, Millecamps Stéphanie, Vourc'h Patrick, Corcia Philippe, Couratier Philippe, Morrison Karen E, Shaw Pamela J, Shaw Christopher E, Pasterkamp R Jeroen, Landers John E, Van Den Bosch Ludo, Robberecht Wim, Al-Chalabi Ammar, van den Berg Leonard H, Van Damme Philip, Veldink Jan H, van Es Michael A