日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification and Analysis of Axolotl Homologs for Proteins Implicated in Human Neurodegenerative Proteinopathies

与人类神经退行性蛋白病有关的蝾螈同源物的鉴定和分析

Lucas M James, Zachary Strickland, Noah Lopez, Jessica L Whited, Malcolm Maden, Jada Lewis

Anti-tau scFvs Targeted to the Cytoplasm or Secretory Pathway Variably Modify Pathology and Neurodegenerative Phenotypes

针对细胞质或分泌途径的抗 tau scFv 可变地改变病理和神经退行性表型

Marshall S Goodwin, Olga Sinyavskaya, Franklin Burg, Veronica O'Neal, Carolina Ceballos-Diaz, Pedro E Cruz, Jada Lewis, Benoit I Giasson, Peter Davies, Todd E Golde, Yona Levites

Photodynamic studies reveal rapid formation and appreciable turnover of tau inclusions

光动力学研究揭示了 tau 内含物的快速形成和显著的周转

Cara L Croft, Marshall S Goodwin, Daniel H Ryu, Christian B Lessard, Giancarlo Tejeda, Marc Marrero, Ava R Vause, Giavanna Paterno, Pedro E Cruz, Jada Lewis, Benoit I Giasson, Todd E Golde

Diversity in Aβ deposit morphology and secondary proteome insolubility across models of Alzheimer-type amyloidosis

阿尔茨海默型淀粉样变性模型中 Aβ 沉积物形态和次级蛋白质组不溶性的多样性

Guilian Xu, Susan E Fromholt, Paramita Chakrabarty, Fanchao Zhu, Xuefei Liu, Michael C Pace, Jin Koh, Todd E Golde, Yona Levites, Jada Lewis, David R Borchelt

Intracerebral Expression of AAV-APOE4 Is Not Sufficient to Alter Tau Burden in Two Distinct Models of Tauopathy

在两种不同的 Tau 蛋白病模型中,AAV-APOE4 的脑内表达不足以改变 Tau 蛋白负担

Emily J Koller, Elsa Gonzalez De La Cruz, Mary Weinrich, Tosha Williams, Pedro E Cruz, Daniel Ryu, Todd E Golde, Patrick M Sullivan, Jada Lewis, David R Borchelt, Paramita Chakrabarty

Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology

tau 和 α-突触核蛋白病理对突变 SOD1 错误折叠和聚集的差异诱导

Michael C Pace, Guilian Xu, Susan Fromholt, John Howard, Benoit I Giasson, Jada Lewis, David R Borchelt

Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease

蛋白质组溶解度的变化表明神经退行性疾病小鼠模型中存在广泛的蛋白质稳态破坏

Michael C Pace, Guilian Xu, Susan Fromholt, John Howard, Keith Crosby, Benoit I Giasson, Jada Lewis, David R Borchelt

Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics

Lrrk 通过肌动蛋白和线粒体动力学失调促进 tau 神经毒性

Farah H Bardai, Dalila G Ordonez, Rachel M Bailey, Matthew Hamm, Jada Lewis, Mel B Feany

Analysis of spinal and muscle pathology in transgenic mice overexpressing wild-type and ALS-linked mutant MATR3

对过表达野生型和ALS相关突变型MATR3的转基因小鼠的脊髓和肌肉病理进行分析

Christina Moloney ,Sruti Rayaprolu ,John Howard ,Susan Fromholt ,Hilda Brown ,Matt Collins ,Mariela Cabrera ,Colin Duffy ,Zoe Siemienski ,Dave Miller ,David R Borchelt ,Jada Lewis

Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy

对与肌萎缩侧索硬化症和肌病相关的Matrin 3编码突变进行基因调控和蛋白质相互作用网络表征

M Carolina Gallego Iradi,Judy C Triplett,James D Thomas,Rachel Davila,Anthony M Crown,Hilda Brown,Jada Lewis,Maurice S Swanson,Guilian Xu,Edgardo Rodriguez-Lebron,David R Borchelt