日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Acquisition of neurodegenerative features in isogenic OPTN(E50K) human stem cell-derived retinal ganglion cells associated with autophagy disruption and mTORC1 signaling reduction

同源 OPTN(E50K) 人类干细胞衍生的视网膜神经节细胞的神经退行性特征的获得与自噬破坏和 mTORC1 信号传导减少有关

Kang-Chieh Huang, Cátia Gomes, Yukihiro Shiga, Nicolas Belforte, Kirstin B VanderWall, Sailee S Lavekar, Clarisse M Fligor, Jade Harkin, Shelby M Hetzer, Shruti V Patil, Adriana Di Polo, Jason S Meyer0

Exploring dysfunctional barrier phenotypes associated with glaucoma using a human pluripotent stem cell-based model of the neurovascular unit

使用基于人类多能干细胞的神经血管单元模型探索与青光眼相关的功能障碍屏障表型

Sailee S Lavekar, Jason M Hughes, Cátia Gomes, Kang-Chieh Huang, Jade Harkin, Scott G Canfield, Jason S Meyer1

Induction of astrocyte reactivity promotes neurodegeneration in human pluripotent stem cell models

诱导星形胶质细胞反应性促进人类多能干细胞模型中的神经退行性

Cátia Gomes, Kang-Chieh Huang, Jade Harkin, Aaron Baker, Jason M Hughes, Yanling Pan, Kaylee Tutrow, Kirstin B VanderWall, Sailee S Lavekar, Melody Hernandez, Theodore R Cummins, Scott G Canfield, Jason S Meyer

Autophagy disruption reduces mTORC1 activation leading to retinal ganglion cell neurodegeneration associated with glaucoma

自噬破坏降低 mTORC1 活性,导致与青光眼相关的视网膜神经节细胞神经变性

Kang-Chieh Huang, Cátia Gomes, Yukihiro Shiga, Nicolas Belforte, Kirstin B VanderWall, Sailee S Lavekar, Clarisse M Fligor, Jade Harkin, Adriana Di Polo, Jason S Meyer

Astrocytes modulate neurodegenerative phenotypes associated with glaucoma in OPTN(E50K) human stem cell-derived retinal ganglion cells

星形胶质细胞调节 OPTN(E50K)人类干细胞衍生的视网膜神经节细胞中与青光眼相关的神经退行性表型

Cátia Gomes, Kirstin B VanderWall, Yanling Pan, Xiaoyu Lu, Sailee S Lavekar, Kang-Chieh Huang, Clarisse M Fligor, Jade Harkin, Chi Zhang, Theodore R Cummins, Jason S Meyer

HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure

胚胎心肌内 HAND1 功能丧失揭示了可存活的先天性心脏缺陷和成人心力衰竭

Beth A Firulli, Rajani M George, Jade Harkin, Kevin P Toolan, Hongyu Gao, Yunlong Liu, Wenjun Zhang, Loren J Field, Ying Liu, Weinian Shou, Ronald Mark Payne, Michael Rubart-von der Lohe, Anthony B Firulli