日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

KDM4C inhibition blocks tumor growth in basal breast cancer by promoting cathepsin L-mediated histone H3 cleavage.

KDM4C 抑制剂通过促进组织蛋白酶 L 介导的组蛋白 H3 裂解来阻断基底型乳腺癌的肿瘤生长

Li Zheqi, Peluffo Guillermo, Stevens Laura E, Qiu Xintao, Seehawer Marco, Tawawalla Amatullah, Huang Xiao-Yun, Egri Shawn B, Raval Shaunak, McFadden Maeve, D'Santos Clive S, Papachristou Eva, Kingston Natalie L, Nishida Jun, Evans Kyle E, Seo Ji-Heui, Clement Kendell, Temko Daniel, Ekram Muhammad, Li Rong, Rees Matthew G, Ronan Melissa M, Roth Jennifer A, Simeonov Anton, Kales Stephen C, Rai Ganesha, Lal-Nag Madhu, Maloney David J, Jadhav Ajit, Michor Franziska, Meissner Alex, Balko Justin M, Carroll Jason S, Freedman Matthew L, Jaffe Jacob D, Papanastasiou Malvina, Long Henry W, Polyak Kornelia

Identifying Molecular Properties of Ataxin-2 Inhibitors for Spinocerebellar Ataxia Type 2 Utilizing High-Throughput Screening and Machine Learning

利用高通量筛选和机器学习鉴定脊髓小脑性共济失调2型中Ataxin-2抑制剂的分子特性

Sahay, Smita; Wen, Jingran; Scoles, Daniel R; Simeonov, Anton; Dexheimer, Thomas S; Jadhav, Ajit; Kales, Stephen C; Sun, Hongmao; Pulst, Stefan M; Facelli, Julio C; Jones, David E

NCATS Inxight Drugs: a comprehensive and curated portal for translational research

NCATS Inxight Drugs:一个全面且精选的转化研究门户网站

Siramshetty, Vishal B; Grishagin, Ivan; Nguyễn, Ðắc-Trung; Peryea, Tyler; Skovpen, Yulia; Stroganov, Oleg; Katzel, Daniel; Sheils, Timothy; Jadhav, Ajit; Mathé, Ewy A; Southall, Noel T

A platform of assays for the discovery of anti-Zika small-molecules with activity in a 3D-bioprinted outer-blood-retina model

用于发现对3D生物打印外血视网膜模型具有活性的抗寨卡小分子的检测平台

Dorjsuren, Dorjbal; Eastman, Richard T; Song, Min Jae; Yasgar, Adam; Chen, Yuchi; Bharti, Kapil; Zakharov, Alexey V; Jadhav, Ajit; Ferrer, Marc; Shi, Pei-Yong; Simeonov, Anton

Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites

通过对疟原虫血液期和肝脏期寄生虫进行定量高通量筛选,鉴定出具有化学保护作用的抗疟药

Dorjsuren, Dorjbal; Eastman, Richard T; Wicht, Kathryn J; Jansen, Daniel; Talley, Daniel C; Sigmon, Benjamin A; Zakharov, Alexey V; Roncal, Norma; Girvin, Andrew T; Antonova-Koch, Yevgeniya; Will, Paul M; Shah, Pranav; Sun, Hongmao; Klumpp-Thomas, Carleen; Mok, Sachel; Yeo, Tomas; Meister, Stephan; Marugan, Juan Jose; Ross, Leila S; Xu, Xin; Maloney, David J; Jadhav, Ajit; Mott, Bryan T; Sciotti, Richard J; Winzeler, Elizabeth A; Waters, Norman C; Campbell, Robert F; Huang, Wenwei; Simeonov, Anton; Fidock, David A

Optimization of ether and aniline based inhibitors of lactate dehydrogenase

乳酸脱氢酶醚类和苯胺类抑制剂的优化

Christov, Plamen P; Kim, Kwangho; Jana, Somnath; Romaine, Ian M; Rai, Ganesha; Mott, Bryan T; Allweil, Alexander A; Lamers, Alexander; Brimacombe, Kyle R; Urban, Daniel J; Lee, Tobie D; Hu, Xin; Lukacs, Christine M; Davies, Douglas R; Jadhav, Ajit; Hall, Matthew D; Green, Neal; Moore, William J; Stott, Gordon M; Flint, Andrew J; Maloney, David J; Sulikowski, Gary A; Waterson, Alex G

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy.

动态成像显示肿瘤中 LDH 抑制可导致体内代谢快速重编程,并对联合疗法产生敏感性

Oshima Nobu, Ishida Ryo, Kishimoto Shun, Beebe Kristin, Brender Jeffrey R, Yamamoto Kazutoshi, Urban Daniel, Rai Ganesha, Johnson Michelle S, Benavides Gloria, Squadrito Giuseppe L, Crooks Dan, Jackson Joseph, Joshi Abhinav, Mott Bryan T, Shrimp Jonathan H, Moses Michael A, Lee Min-Jung, Yuno Akira, Lee Tobie D, Hu Xin, Anderson Tamara, Kusewitt Donna, Hathaway Helen H, Jadhav Ajit, Picard Didier, Trepel Jane B, Mitchell James B, Stott Gordon M, Moore William, Simeonov Anton, Sklar Larry A, Norenberg Jeffrey P, Linehan W Marston, Maloney David J, Dang Chi V, Waterson Alex G, Hall Matthew, Darley-Usmar Victor M, Krishna Murali C, Neckers Leonard M

Optimization of High-Throughput Methyltransferase Assays for the Discovery of Small Molecule Inhibitors

优化高通量甲基转移酶检测方法以发现小分子抑制剂

Dong, Guangping; Yasgar, Adam; Peterson, Darrell L; Zakharov, Alexey; Talley, Daniel; Cheng, Ken Chih-Chien; Jadhav, Ajit; Simeonov, Anton; Huang, Rong

3399 Systematically Integrating Microbiomes and Exposomes for Translational Research

3399 系统地整合微生物组和暴露组以进行转化研究

Huang, Ruili; Grishagin, Ivan; Wang, Yuhong; Zhao, Tongan; Greene, Jon; Obenauer, John C; Ngan, Deborah; Nguyen, Dac-Trung; Guha, Rajarshi; Jadhav, Ajit; Southall, Noel; Simeonov, Anton; Austin, Christopher P; Gouripeddi, Ram; Miller, Andrew; Eilbeck, Karen; Sward, Katherine; Facelli, Julio C

A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN)

利用高通量筛选方法鉴定沃纳综合征解旋酶-核酸酶 (WRN) 的新型小分子抑制剂

Sommers, Joshua A; Kulikowicz, Tomasz; Croteau, Deborah L; Dexheimer, Thomas; Dorjsuren, Dorjbal; Jadhav, Ajit; Maloney, David J; Simeonov, Anton; Bohr, Vilhelm A; Brosh, Robert M Jr