Antisense oligonucleotides directed against App and Rab5Â normalized endosomal Rab activity and reversed DS-AD-linked degenerative phenotypes in the Dp16 mouse model of Down syndrome.
针对 App 和 Rab5Â 的反义寡核苷酸可使内体 Rab 活性正常化，并逆转唐氏综合征 Dp16 小鼠模型中与 DS-AD 相关的退行性表型
期刊:Alzheimers & Dementia
影响因子:11.1
doi:10.1002/alz.70022
Chen Xu-Qiao, Zuo Xinxin, Becker Ann, Mante Michael, Florio Jazmin B, Jadhav Satish G, Albay Ricardo, Johnstone Aaron, Karachentsev Dmitry, Rissman Robert, Zhao Hien, Dowdy Steven F, Mobley William C
