日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Large-scale transcriptomic analyses of major depressive disorder reveal convergent dysregulation of synaptic pathways in excitatory neurons

对重度抑郁症的大规模转录组分析揭示了兴奋性神经元突触通路的趋同性失调

Goes, Fernando S; Collado-Torres, Leonardo; Zandi, Peter P; Huuki-Myers, Louise; Tao, Ran; Jaffe, Andrew E; Pertea, Geo; Shin, Joo Heon; Weinberger, Daniel R; Kleinman, Joel E; Hyde, Thomas M

Cross-ancestry atlas of gene, isoform, and splicing regulation in the developing human brain

人类发育过程中基因、异构体和剪接调控的跨种族图谱

Wen, Cindy; Margolis, Michael; Dai, Rujia; Zhang, Pan; Przytycki, Pawel F; Vo, Daniel D; Bhattacharya, Arjun; Matoba, Nana; Tang, Miao; Jiao, Chuan; Kim, Minsoo; Tsai, Ellen; Hoh, Celine; Aygün, Nil; Walker, Rebecca L; Chatzinakos, Christos; Clarke, Declan; Pratt, Henry; Peters, Mette A; Gerstein, Mark; Daskalakis, Nikolaos P; Weng, Zhiping; Jaffe, Andrew E; Kleinman, Joel E; Hyde, Thomas M; Weinberger, Daniel R; Bray, Nicholas J; Sestan, Nenad; Geschwind, Daniel H; Roeder, Kathryn; Gusev, Alexander; Pasaniuc, Bogdan; Stein, Jason L; Love, Michael I; Pollard, Katherine S; Liu, Chunyu; Gandal, Michael J

Analysis of gene expression in the postmortem brain of neurotypical Black Americans reveals contributions of genetic ancestry

对神经发育正常的美国黑人死后大脑基因表达的分析揭示了遗传祖先的影响

Benjamin, Kynon J M; Chen, Qiang; Eagles, Nicholas J; Huuki-Myers, Louise A; Collado-Torres, Leonardo; Stolz, Joshua M; Pertea, Geo; Shin, Joo Heon; Paquola, Apuã C M; Hyde, Thomas M; Kleinman, Joel E; Jaffe, Andrew E; Han, Shizhong; Weinberger, Daniel R

The human master circadian clock is vulnerable to tau pathology in the early stages of Alzheimer’s: a postmortem neuropathology using spatial in‐situ proteomics

人类主生物钟在阿尔茨海默病早期阶段易受tau蛋白病理的影响:一项基于空间原位蛋白质组学的死后神经病理学研究

Benjamin, Kynon J M; Chen, Qiang; Jaffe, Andrew E; Stolz, Joshua M; Collado-Torres, Leonardo; Huuki-Myers, Louise A; Burke, Emily E; Arora, Ria; Feltrin, Arthur S; Barbosa, André Rocha; Radulescu, Eugenia; Pergola, Giulio; Shin, Joo Heon; Ulrich, William S; Deep-Soboslay, Amy; Tao, Ran; Hyde, Thomas M; Kleinman, Joel E; Erwin, Jennifer A; Weinberger, Daniel R; Paquola, Apuã C M; Son, Gowoon; Mladinov, Mihovil; Pereira, Felipe Luiz; Li, Song Hua; Tu, Chia‐Ling; Judge, Grace; Suemoto, Claudia Kimie; Leite, Renata Elaine Paraizo; Paes, Vitor Ribeiro; Pasqualucci, Carlos Augusto; Jacob‐Filho, Wilson; Spina, Salvatore; Seeley, William W; Chang, Wenhan; Neylan, Thomas C; Grinberg, Lea T

TCF4 Mutations Disrupt Synaptic Function Through Dysregulation of RIMBP2 in Patient-Derived Cortical Neurons.

TCF4 突变通过患者来源的皮层神经元中 RIMBP2 的失调破坏突触功能

Davis Brittany A, Chen Huei-Ying, Ye Zengyou, Ostlund Isaac, Tippani Madhavi, Das Debamitra, Sripathy Srinidhi Rao, Wang Yanhong, Martin Jacqueline M, Shim Gina, Panchwagh Neel M, Moses Rebecca L, Farinelli Federica, Bohlen Joseph F, Li Meijie, Luikart Bryan W, Jaffe Andrew E, Maher Brady J

Smoking-informed methylation and expression QTLs in human brain and colocalization with smoking-associated genetic loci

吸烟相关的人类大脑甲基化和表达QTL及其与吸烟相关基因位点的共定位

Carnes, Megan Ulmer; Quach, Bryan C; Zhou, Linran; Han, Shizhong; Tao, Ran; Mandal, Meisha; Deep-Soboslay, Amy; Marks, Jesse A; Page, Grier P; Maher, Brion S; Jaffe, Andrew E; Won, Hyejung; Bierut, Laura J; Hyde, Thomas M; Kleinman, Joel E; Johnson, Eric O; Hancock, Dana B

Molecular impact of nicotine and smoking exposure on the developing and adult mouse brain

尼古丁和吸烟暴露对发育中和成年小鼠大脑的分子影响

Gonzalez-Padilla, Daianna; Eagles, Nicholas J; Cano, Marisol; Pertea, Geo; Jaffe, Andrew E; Maynard, Kristen R; Hancock, Dana B; Handa, James T; Martinowich, Keri; Collado-Torres, Leonardo

Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing

多种族转录组关联分析揭示了烟草使用生物学和药物再利用的奥秘

Chen, Fang; Wang, Xingyan; Jang, Seon-Kyeong; Quach, Bryan C; Weissenkampen, J Dylan; Khunsriraksakul, Chachrit; Yang, Lina; Sauteraud, Renan; Albert, Christine M; Allred, Nicholette D D; Arnett, Donna K; Ashley-Koch, Allison E; Barnes, Kathleen C; Barr, R Graham; Becker, Diane M; Bielak, Lawrence F; Bis, Joshua C; Blangero, John; Boorgula, Meher Preethi; Chasman, Daniel I; Chavan, Sameer; Chen, Yii-Der I; Chuang, Lee-Ming; Correa, Adolfo; Curran, Joanne E; David, Sean P; de las Fuentes, Lisa; Deka, Ranjan; Duggirala, Ravindranath; Faul, Jessica D; Garrett, Melanie E; Gharib, Sina A; Guo, Xiuqing; Hall, Michael E; Hawley, Nicola L; He, Jiang; Hobbs, Brian D; Hokanson, John E; Hsiung, Chao A; Hwang, Shih-Jen; Hyde, Thomas M; Irvin, Marguerite R; Jaffe, Andrew E; Johnson, Eric O; Kaplan, Robert; Kardia, Sharon L R; Kaufman, Joel D; Kelly, Tanika N; Kleinman, Joel E; Kooperberg, Charles; Lee, I-Te; Levy, Daniel; Lutz, Sharon M; Manichaikul, Ani W; Martin, Lisa W; Marx, Olivia; McGarvey, Stephen T; Minster, Ryan L; Moll, Matthew; Moussa, Karine A; Naseri, Take; North, Kari E; Oelsner, Elizabeth C; Peralta, Juan M; Peyser, Patricia A; Psaty, Bruce M; Rafaels, Nicholas; Raffield, Laura M; Reupena, Muagututi'a Sefuiva; Rich, Stephen S; Rotter, Jerome I; Schwartz, David A; Shadyab, Aladdin H; Sheu, Wayne H-H; Sims, Mario; Smith, Jennifer A; Sun, Xiao; Taylor, Kent D; Telen, Marilyn J; Watson, Harold; Weeks, Daniel E; Weir, David R; Yanek, Lisa R; Young, Kendra A; Young, Kristin L; Zhao, Wei; Hancock, Dana B; Jiang, Bibo; Vrieze, Scott; Liu, Dajiang J

Comment on: What genes are differentially expressed in individuals with schizophrenia? A systematic review

评论:精神分裂症患者中哪些基因存在差异表达?一项系统性综述

Hoffman, Gabriel E; Jaffe, Andrew E; Gandal, Michael J; Collado-Torres, Leonardo; Sieberts, Solveig K; Devlin, Bernie; Geschwind, Daniel H; Weinberger, Daniel R; Roussos, Panos

The basolateral amygdala to lateral septum circuit is critical for regulating social novelty in mice

基底外侧杏仁核至侧隔核回路对于调节小鼠的社会新颖性至关重要。

Rodriguez, Lionel A; Kim, Sun-Hong; Page, Stephanie C; Nguyen, Claudia V; Pattie, Elizabeth A; Hallock, Henry L; Valerino, Jessica; Maynard, Kristen R; Jaffe, Andrew E; Martinowich, Keri