日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Small molecule SJ572946 activates BAK to initiate apoptosis

小分子SJ572946激活BAK启动细胞凋亡

Giridhar Sekar ,Geetika Singh ,Xingping Qin ,Cristina D Guibao ,Brittany Schwam ,Zintis Inde ,Christy R Grace ,Weixing Zhang ,P Jake Slavish ,Wenwei Lin ,Taosheng Chen ,Richard E Lee ,Zoran Rankovic ,Kristopher Sarosiek ,Tudor Moldoveanu

Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators

从聚焦的 Cereblon 调节剂库中鉴定高效、选择性强且口服生物利用度高的小分子 GSPT1/2 降解剂

Gisele Nishiguchi,Fatemeh Keramatnia,Jaeki Min,Yunchao Chang,Barbara Jonchere,Sourav Das,Marisa Actis,Jeanine Price,Divyabharathi Chepyala,Brandon Young,Kevin McGowan,P Jake Slavish,Anand Mayasundari,Jamie A Jarusiewicz,Lei Yang,Yong Li,Xiang Fu,Shalandus H Garrett,James B Papizan,Kiran Kodali,Junmin Peng,Shondra M Pruett Miller,Martine F Roussel,Charles Mullighan,Marcus Fischer,Zoran Rankovic

Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs

苯基戊二酰亚胺:用于 PROTAC 设计的替代 Cereblon 粘合剂

Jaeki Min, Anand Mayasundari, Fatemeh Keramatnia, Barbara Jonchere, Seung Wook Yang, Jamie Jarusiewicz, Marisa Actis, Sourav Das, Brandon Young, Jake Slavish, Lei Yang, Yong Li, Xiang Fu, Shalandus H Garrett, Mi-Kyung Yun, Zhenmei Li, Stanley Nithianantham, Sergio Chai, Taosheng Chen, Anang Shelat, 

Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer

溴结构域选择性 BET 抑制剂是针对 MYC 驱动的儿童癌症的有效抗肿瘤药物

P Jake Slavish #, Liying Chi #, Mi-Kyung Yun #, Lyudmila Tsurkan #, Nancy E Martinez, Barbara Jonchere, Sergio C Chai, Michele Connelly, M Brett Waddell, Sourav Das, Geoffrey Neale, Zhenmei Li, William R Shadrick, Rachelle R Olsen, Kevin W Freeman, Jonathan A Low, Jeanine E Price, Brandon M Young, N

Structural and biochemical basis for development of influenza virus inhibitors targeting the PA endonuclease

针对 PA 核酸内切酶的流感病毒抑制剂开发的结构和生化基础

Rebecca M DuBois, P Jake Slavish, Brandi M Baughman, Mi-Kyung Yun, Ju Bao, Richard J Webby, Thomas R Webb, Stephen W White

Identification of influenza endonuclease inhibitors using a novel fluorescence polarization assay

利用新型荧光偏振法鉴定流感核酸内切酶抑制剂

Baughman, Brandi M; Jake Slavish, P; DuBois, Rebecca M; Boyd, Vincent A; White, Stephen W; Webb, Thomas R

Design and synthesis of a novel tyrosine kinase inhibitor template

新型酪氨酸激酶抑制剂模板的设计与合成

Jake Slavish, P; Jiang, Qin; Cui, Xiaoli; Morris, Stephan W; Webb, Thomas R