日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The Cyclin C-CDK8/19 Mediator kinase module controls PRCC-TFE3 driven senescence in renal epithelium and tumorigenesis in TFE3-RCC

细胞周期蛋白C-CDK8/19介导激酶模块控制PRCC-TFE3驱动的肾上皮细胞衰老和TFE3-RCC的肿瘤发生。

Kuroda, Shoichiro; Funasaki, Shintaro; Nishizawa, Hidekazu; Schmidt, Laura S; Kurahashi, Ryoma; Ito, Takaaki; Arima, Yuichiro; Tanaka, Miwa; Kitada, Atsuya; James, Amy M; Hasumi, Hisashi; Jikuya, Ryosuke; Makiyama, Kazuhide; Kurotaki, Daisuke; Minami, Takashi; Difilippantonio, Simone; Linehan, W Marston; Oike, Yuichi; Sawa, Tomohiro; Tanaka, Yasuhito; Suda, Toshio; Yokokawa, Ryuji; Nakamura, Takuro; Baba, Masaya; Kamba, Tomomi

Targeting c-MYC and gain-of-function p53 through inhibition or degradation of the kinase LZK suppresses the growth of HNSCC tumors.

通过抑制或降解激酶 LZK 来靶向 c-MYC 和获得功能的 p53,可以抑制 HNSCC 肿瘤的生长

Funk Amy L, Katerji Meghri, Afifi Marwa, Nyswaner Katherine, Woodroofe Carolyn C, Edwards Zoe C, Lindberg Eric, Bergman Knickole L, Gough Nancy R, Rubin Maxine R, Karpińska Kamila, Trotter Eleanor W, Dash Sweta, Ries Amy L, James Amy, Robinson Christina M, Difilippantonio Simone, Karim Baktiar O, Chang Ting-Chia, Chen Li, Xu Xin, Doroshow James H, Ahel Ivan, Marusiak Anna A, Swenson Rolf E, Cappell Steven D, Brognard John

Targeting NAD+ Metabolism Vulnerability in FH-Deficient Hereditary Leiomyomatosis and Renal Cell Carcinoma with the Novel NAMPT Inhibitor OT-82.

利用新型 NAMPT 抑制剂 OT-82 靶向 FH 缺陷型遗传性平滑肌瘤病和肾细胞癌中的 NAD+ 代谢脆弱性

Najera Susana S, Ricketts Christopher J, Schmidt Laura S, Medina Julia I, Saito Keita, Ileva Lilia, Brender Jeffrey R, James Amy M, Peer Cody J, Gouker Brad, Karim Baktiar O, Chernova Olga, Wells Catherine, Wei Ming-Hui, Yang Youfeng, Zhang Xiaohu, Klumpp-Thomas Carleen, Travers Jameson, Chen Lu, Wilson Kelli M, Issaq Sameer H, Figg William D, Difilippantonio Simone, Kalen Joseph D, Krishna Murali C, Thomas Craig J, Ceribelli Michele, Heske Christine M, Crooks Daniel R, Meier Jordan L

CAR memory-like NK cells targeting the membrane proximal domain of mesothelin demonstrate promising activity in ovarian cancer

靶向间皮素膜近端结构域的 CAR 记忆样 NK 细胞在卵巢癌中表现出良好的活性

Mubin Tarannum, Khanhlinh Dinh, Juliana Vergara, Grace Birch, Yasmin Z Abdulhamid, Isabel E Kaplan, Oyku Ay, Andreia Maia, Owen Beaver, Michal Sheffer, Roman Shapiro, Alaa Kassim Ali, Han Dong, James Dongjoo Ham, Eden Bobilev, Sydney James, Amy B Cameron, Quang-De Nguyen, Suthakar Ganapathy, Chayapa

Targeting GOF p53 and c-MYC through LZK Inhibition or Degradation Suppresses Head and Neck Tumor Growth.

通过抑制或降解 LZK 靶向 GOF p53 和 c-MYC 可抑制头颈部肿瘤生长

Funk Amy L, Katerji Meghri, Afifi Marwa, Nyswaner Katherine, Woodroofe Carolyn C, Edwards Zoe C, Lindberg Eric, Bergman Knickole L, Gough Nancy R, Rubin Maxine R, Karpińska Kamila, Trotter Eleanor W, Dash Sweta, Ries Amy L, James Amy, Robinson Christina M, Difilippantonio Simone, Karim Baktiar O, Chang Ting-Chia, Chen Li, Xu Xin, Doroshow James H, Ahel Ivan, Marusiak Anna A, Swenson Rolf E, Cappell Steven D, Brognard John

Modulation of hepatic transcription factor EB activity during cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by Pla2g15

冷暴露期间肝转录因子 EB 活性的调节揭示了 Pla2g15 对双(单酰基甘油)磷酸脂质的直接调节

Raghav Jain, Gisela Geoghegan, Jessica Davidson, Daniel J Nesbitt, Akira Abe, Xiaojuan Chao, Isabella James, Amy Cavanagh, Sylwia Michorowska, Rakesh Verma, Kathryn Scheuler, Vania Hinkovska-Galcheva, Evgenia Shishkova, Wen-Xing Ding, Joshua J Coon, James A Shayman, Judith A Simcox

3'-[(18)F]fluoro-3'-deoxythymidine ([(18)F]FLT) Positron Emission Tomography as an In Vivo Biomarker of inhibition of CDK 4/6-Rb pathway by Palbociclib in a patient derived bladder tumor

3'-[(18)F]氟-3'-脱氧胸苷 ([(18)F]FLT) 正电子发射断层扫描作为体内生物标志物,用于检测帕博西尼在患者来源的膀胱肿瘤中对 CDK 4/6-Rb 通路的抑制作用

Tatum, James L; Kalen, Joseph D; Jacobs, Paula M; Riffle, Lisa A; James, Amy; Thang, Lai; Sanders, Chelsea; Hollingshead, Melinda G; Basuli, Falguni; Shi, Jianfeng; Doroshow, James H

Viral inosine triphosphatase: A mysterious enzyme with typical activity, but an atypical function

病毒肌苷三磷酸酶:一种具有典型活性但功能非典型的神秘酶

James, Amy M; Seal, Susan E; Bailey, Andy M; Foster, Gary D

Cultivation of hierarchical 3D scaffolds inside a perfusion bioreactor: scaffold design and finite-element analysis of fluid flow

灌注生物反应器内分层三维支架的培养:支架设计和流体流动的有限元分析

Kaylie Sampson, Songmi Koo, Carter Gadola, Anastasiia Vasiukhina, Aditya Singh, Alexandra Spartano, Rachana Gollapudi, Matthew Duley, Jens Mueller, Paul F James, Amy M Yousefi

Predictive modeling in neurocritical care using causal artificial intelligence

利用因果人工智能进行神经重症监护预测建模

Dang, Johnny; Lal, Amos; Flurin, Laure; James, Amy; Gajic, Ognjen; Rabinstein, Alejandro A