日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mechanistic insights into lenacapavir-induced off-pathway HIV-1 capsid assembly

对lenacapavir诱导的非正常HIV-1衣壳组装的机制研究

Gupta, Manish; Waltmann, Curt; Renner, Nadine; Wang, Yihang; James, Leo C; Jacques, David A; Böcking, Till; Voth, Gregory A

Vaccine-induced antibodies can limit Salmonella infection in the absence of complement or macrophages

疫苗诱导产生的抗体可以在没有补体或巨噬细胞的情况下限制沙门氏菌感染。

Perez-Toledo, Marisol; Aksu-Istil, Kubra; Marcial-Juarez, Edith; Persaud, Ruby R; Alshayea, Areej; Jossi, Sian E; Carestia, Agostina; von Meijenfeld, Fien; Botto, Marina; James, Leo C; Surewaard, Bas; Afzal, Zaheer; Shields, Adrian M; Horsnell, William G; Lopez-Macias, Constantino; Henderson, Ian R; Jenne, Craig N; Cunningham, Adam F

The host protein cyclophilin A restricts nuclear entry of HIV-1 mutants by reducing the elasticity of the viral capsid

宿主蛋白环孢亲和素A通过降低病毒衣壳的弹性来限制HIV-1突变体进入细胞核。

Hong, Jun; Deshpande, Akshay; Thakare, Yatish; Simonovsky, Lora; Douglas, AidanDarian W; Guinness, Conall Mc; Rotem-Dai, Noa; Kortyna, Michelle L; Klarhof, J Ole; Shi, Jiong; James, Leo C; Boecking, Till; Francis, Ashwanth C; Rousso, Itay; Aiken, Christopher

UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains.

UbiREAD 可破译同型和分支型 K48 和 K63 泛素链的蛋白酶体降解密码

Kiss Leo, James Leo C, Schulman Brenda A

State-selective small molecule degraders that preferentially remove aggregates and oligomers.

选择性小分子降解剂,优先去除聚集体和低聚物。

Luptak Jakub, Clift Dean, Mukadam Aamir, Benn Jonathan, Rhinesmith Tyler, McLaughlin Stephen H, Dodds Amy C, Lapetaje Jerson E, Sczaniecka-Clift Matylda, France David J, McEwan William A, James Leo C

The host protein cyclophilin A inhibits HIV-1 nuclear entry by decreasing capsid elasticity

宿主蛋白亲环蛋白A通过降低衣壳弹性来抑制HIV-1进入细胞核。

Hong, Jun; Deshpande, Akshay; Thakare, Yatish; Simonovsky, Lora; Douglas, AidanDarian W; Mc Guinness, Conall; Rotem-Dai, Noa; Kortyna, Michelle L; Klarhof, J Ole; Shi, Jiong; Boecking, Till; James, Leo C; Francis, Ashwanth C; Rousso, Itay; Aiken, Christopher

How HIV-1 Uses the Metabolite Inositol Hexakisphosphate to Build Its Capsid

HIV-1如何利用代谢物六磷酸肌醇构建其衣壳

James, Leo C

The central pore of HIV-1 capsomers promotes sustained stability of the viral capsid.

HIV-1 衣壳蛋白的中心孔促进病毒衣壳的持续稳定性

Kleinpeter Alex B, Mallery Donna L, Albecka Anna, Burdick Ryan C, Renner Nadine, Klarhof J Ole, Vamos Boglarka, Pathak Vinay K, James Leo C, Freed Eric O

Human coronaviruses activate and hijack the host transcription factor HSF1 to enhance viral replication

人类冠状病毒激活并劫持宿主转录因子HSF1以增强病毒复制。

Pauciullo, Silvia; Riccio, Anna; Santopolo, Silvia; Albecka, Anna; Papa, Guido; James, Leo C; Piacentini, Sara; Lanzilli, Giulia; Rossi, Antonio; Santoro, M Gabriella

Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding

HIV-1衣壳中的两个结构开关调节衣壳曲率和宿主因子结合

Stacey, James C V; Tan, Aaron; Lu, John M; James, Leo C; Dick, Robert A; Briggs, John A G