日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections

宿主来源的氧化磷脂通过表观遗传机制沉默白细胞介素-10,从而促进对感染的致命性炎症反应。

Marco Di Gioia ,Valentina Poli ,Piao J Tan ,Roberto Spreafico ,Anne Chu ,Alex G Cuenca ,Zhongyang Wu ,Mehdi Benamar ,Laura Pandolfi ,Federica Meloni ,Fatemeh Askarian ,Jason Hsiao ,Elizaveata Borroum ,Victor Nizet ,Philip L S M Gordts ,Joseph L Witztum ,Talal A Chatila ,Janet Chou ,Xu Zhou ,James R Springstead ,Ivan Zanoni

Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter

宿主衍生的氧化磷脂启动效应器触发的免疫,在遇到微生物时促进杀伤力

Marco Di Gioia, Valentina Poli, Piao J Tan, Roberto Spreafico, Anne Chu, Alex G Cuenca, Philip Lsm Gordts, Laura Pandolfi, Federica Meloni, Joseph L Witztum, Janet Chou, James R Springstead, Ivan Zanoni

Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation

内源性氧化磷脂重编程细胞代谢并加剧炎症反应

Marco Di Gioia ,Roberto Spreafico ,James R Springstead ,Michael M Mendelson ,Roby Joehanes ,Daniel Levy ,Ivan Zanoni

By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation

CD14受体通过捕获垂死细胞释放的炎症脂质,诱导炎症小体依赖性吞噬细胞过度活化。

Ivan Zanoni ,Yunhao Tan ,Marco Di Gioia ,James R Springstead ,Jonathan C Kagan

Transcriptional networks specifying homeostatic and inflammatory programs of gene expression in human aortic endothelial cells

转录网络指定人类主动脉内皮细胞中基因表达的稳态和炎症程序

Nicholas T Hogan, Michael B Whalen, Lindsey K Stolze, Nizar K Hadeli, Michael T Lam, James R Springstead, Christopher K Glass, Casey E Romanoski

HDL inhibits the effects of oxidized phospholipids on endothelial cell gene expression via multiple mechanisms

HDL通过多种机制抑制氧化磷脂对内皮细胞基因表达的影响

Benjamin Emert, Yehudit Hasin-Brumshtein, James R Springstead, Ladan Vakili, Judith A Berliner, Aldons J Lusis

A novel approach to oral apoA-I mimetic therapy

口服载脂蛋白A-I类似物治疗的新方法

Arnab Chattopadhyay, Mohamad Navab, Greg Hough, Feng Gao, David Meriwether, Victor Grijalva, James R Springstead, Mayakonda N Palgnachari, Ryan Namiri-Kalantari, Feng Su, Brian J Van Lenten, Alan C Wagner, G M Anantharamaiah, Robin Farias-Eisner, Srinivasa T Reddy, Alan M Fogelman