日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation

polo 样激酶 PLK1 的 polo-box 结构域中的隐秘疏水口袋调节底物识别和有丝分裂染色体分离

Pooja Sharma, Robert Mahen, Maxim Rossmann, Jamie E Stokes, Bryn Hardwick, David J Huggins, Amy Emery, Dominique L Kunciw, Marko Hyvönen, David R Spring, Grahame J McKenzie, Ashok R Venkitaraman

Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2

通过小分子抑制剂对 AURKA 激酶活性进行变构调节,抑制其与 TPX2 的蛋白质-蛋白质相互作用

Matej Janeček, Maxim Rossmann, Pooja Sharma, Amy Emery, David J Huggins, Simon R Stockwell, Jamie E Stokes, Yaw S Tan, Estrella Guarino Almeida, Bryn Hardwick, Ana J Narvaez, Marko Hyvönen, David R Spring, Grahame J McKenzie, Ashok R Venkitaraman