Jamie Toombs相关文献与解析，生知库 | 链接生命科学的每一步

Martí Colom-Cadena, Jamie Toombs, Elizabeth Simzer, Kristjan Holt, Robert McGeachan, Jane Tulloch, Rosemary J Jackson, James H Catterson, Maxwell P Spires-Jones, Jamie Rose, Lora Waybright, Anthony O Caggiano, Declan King, Francesco Gobbo, Caitlin Davies, Monique Hooley, Sophie Dunnett, Robert Tempe

神经

阿尔茨海默症

ELISA

Human

发表日期：2024

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The PSEN1 E280G mutation leads to increased amyloid-β43 production in induced pluripotent stem cell neurons and deposition in brain tissue

PSEN1 E280G突变导致诱导多能干细胞神经元中β-淀粉样蛋白43的产生增加，并在脑组织中沉积。

期刊:Brain Communications

影响因子:4.1

doi:10.1093/braincomms/fcac321

Nanet Willumsen ，Charles Arber ，Christopher Lovejoy ，Jamie Toombs ，Argyro Alatza ，Philip S J Weston ，Lucia Chávez-Gutiérrez ，John Hardy ，Henrik Zetterberg ，Nick C Fox ，Natalie S Ryan ，Tammaryn Lashley ，Selina Wray

Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimer's disease

降低电压依赖性钾通道 Kv3.4 水平可改善阿尔茨海默病小鼠模型中的突触丢失

期刊:Brain and Neuroscience Advances

影响因子:

doi:10.1177/23982128221086464

Jie Yeap, Chaitra Sathyaprakash, Jamie Toombs, Jane Tulloch, Cristina Scutariu, Jamie Rose, Karen Burr, Caitlin Davies, Marti Colom-Cadena, Siddharthan Chandran, Charles H Large, Matthew J M Rowan, Martin J Gunthorpe, Tara L Spires-Jones

Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta

家族性阿尔茨海默病患者来源的神经元揭示了特定突变对β-淀粉样蛋白的独特影响。

期刊:Molecular Psychiatry

影响因子:9.6

doi:10.1038/s41380-019-0410-8

Charles Arber # ，Jamie Toombs # ，Christopher Lovejoy ，Natalie S Ryan ，Ross W Paterson ，Nanet Willumsen ，Eleni Gkanatsiou ，Erik Portelius ，Kaj Blennow ，Amanda Heslegrave ，Jonathan M Schott ，John Hardy ，Tammaryn Lashley ，Nick C Fox ，Henrik Zetterberg # ，Selina Wray #

Haemoglobin causes neuronal damage in vivo which is preventable by haptoglobin

血红蛋白会导致体内神经元损伤，而结合珠蛋白可以预防这种损伤

期刊:Brain Communications

影响因子:4.1

doi:10.1093/braincomms/fcz053

Patrick Garland, Matthew J Morton #, William Haskins #, Ardalan Zolnourian, Andrew Durnford, Ben Gaastra, Jamie Toombs, Amanda J Heslegrave, John More, Azubuike I Okemefuna, Jessica L Teeling, Jonas H Graversen, Henrik Zetterberg, Soren K Moestrup, Diederik O Bulters, Ian Galea

神经

发表日期：2020

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Cerebrospinal Fluid Biomarkers in Cerebral Amyloid Angiopathy

脑淀粉样血管病的脑脊液生物标志物

期刊:Journal of Alzheimers Disease

影响因子:3.4

doi:10.3233/JAD-191254

Gargi Banerjee, Gareth Ambler, Ashvini Keshavan, Ross W Paterson, Martha S Foiani, Jamie Toombs, Amanda Heslegrave, John C Dickson, Francesco Fraioli, Ashley M Groves, Michael P Lunn, Nick C Fox, Henrik Zetterberg, Jonathan M Schott, David J Werring

信号转导

发表日期：2020

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Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936

从 1936 年洛锡安出生队列的 24 名成员中生成 24 种诱导性多能干细胞系

期刊:Stem Cell Research

影响因子:0.8

doi:10.1016/j.scr.2020.101851

Jamie Toombs, Lindsay Panther, Loren Ornelas, Chunyan Liu, Emilda Gomez, Raquel Martín-Ibáñez, Simon R Cox, Stuart J Ritchie, Sarah E Harris, Adele Taylor, Paul Redmond, Tom C Russ, Lee Murphy, James D Cooper, Karen Burr, Bhuvaneish T Selvaraj, Cathy Browne, Clive N Svendsen, Sally A Cowley, Ian J D

Amyloid precursor protein processing in human neurons with an allelic series of the PSEN1 intron 4 deletion mutation and total presenilin-1 knockout

PSEN1 内含子 4 缺失突变等位基因系列和完全早老素-1 敲除的人类神经元中淀粉样前体蛋白的加工

期刊:Brain Communications

影响因子:4.1

doi:10.1093/braincomms/fcz024

Charles Arber ，Claudio Villegas-Llerena ，Jamie Toombs ，Jennifer M Pocock ，Natalie S Ryan ，Nick C Fox ，Henrik Zetterberg ，John Hardy ，Selina Wray

神经科学

发表日期：2019

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Amyloid β peptides are differentially vulnerable to preanalytical surface exposure, an effect incompletely mitigated by the use of ratios

淀粉样β肽对分析前表面暴露的敏感性存在差异，使用比率可以不完全减轻这种影响

期刊:Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

影响因子:

doi:10.1016/j.dadm.2018.02.005

Jamie Toombs, Martha S Foiani, Henrietta Wellington, Ross W Paterson, Charles Arber, Amanda Heslegrave, Michael P Lunn, Jonathan M Schott, Selina Wray, Henrik Zetterberg

发表日期：2018

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Effect of Spinal Manometers on Cerebrospinal Fluid Amyloid-β Concentration

脊髓压力计对脑脊液淀粉样蛋白-β浓度的影响

期刊:Journal of Alzheimers Disease

影响因子:3.4

doi:10.3233/JAD-161126

Jamie Toombs, Martha S Foiani, Ross W Paterson, Amanda Heslegrave, Selina Wray, Jonathan M Schott, Nick C Fox, Michael P Lunn, Kaj Blennow, Henrik Zetterberg

神经科学

发表日期：2017

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Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer's disease

跨膜蛋白 97 是人类阿尔茨海默病中潜在的突触淀粉样蛋白 β 受体

The PSEN1 E280G mutation leads to increased amyloid-β43 production in induced pluripotent stem cell neurons and deposition in brain tissue

PSEN1 E280G突变导致诱导多能干细胞神经元中β-淀粉样蛋白43的产生增加，并在脑组织中沉积。

Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimer's disease

降低电压依赖性钾通道 Kv3.4 水平可改善阿尔茨海默病小鼠模型中的突触丢失

Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta

家族性阿尔茨海默病患者来源的神经元揭示了特定突变对β-淀粉样蛋白的独特影响。

Haemoglobin causes neuronal damage in vivo which is preventable by haptoglobin

血红蛋白会导致体内神经元损伤，而结合珠蛋白可以预防这种损伤

Cerebrospinal Fluid Biomarkers in Cerebral Amyloid Angiopathy

脑淀粉样血管病的脑脊液生物标志物

Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936

从 1936 年洛锡安出生队列的 24 名成员中生成 24 种诱导性多能干细胞系

Amyloid precursor protein processing in human neurons with an allelic series of the PSEN1 intron 4 deletion mutation and total presenilin-1 knockout

PSEN1 内含子 4 缺失突变等位基因系列和完全早老素-1 敲除的人类神经元中淀粉样前体蛋白的加工

Amyloid β peptides are differentially vulnerable to preanalytical surface exposure, an effect incompletely mitigated by the use of ratios

淀粉样β肽对分析前表面暴露的敏感性存在差异，使用比率可以不完全减轻这种影响

Effect of Spinal Manometers on Cerebrospinal Fluid Amyloid-β Concentration

脊髓压力计对脑脊液淀粉样蛋白-β浓度的影响