日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Non-linear IV pharmacokinetics of the ATR inhibitor berzosertib (M6620) in mice

ATR 抑制剂 berzosertib (M6620) 在小鼠体内的非线性 IV 药代动力学

Joshua J Deppas, Brian F Kiesel, Jianxia Guo, Robert A Parise, D Andy Clump, David Z D'Argenio, Christopher J Bakkenist, Jan H Beumer

The schedule of ATR inhibitor AZD6738 can potentiate or abolish antitumor immune responses to radiotherapy

ATR 抑制剂 AZD6738 的给药方案可以增强或消除放射治疗的抗肿瘤免疫反应

Frank P Vendetti, Pinakin Pandya, David A Clump, Sandra Schamus-Haynes, Meysam Tavakoli, Maria diMayorca, Naveed M Islam, Jina Chang, Greg M Delgoffe, Jan H Beumer, Christopher J Bakkenist

Tumor cell p38 inhibition to overcome immunotherapy resistance

肿瘤细胞 p38 抑制可克服免疫疗法耐药性

Jason J Luke, Rebekah E Dadey, Ryan C Augustin, Sarah Newman, Krishna B Singh, Rose Doerfler, Sarah Behr, Patrice Lee, Brian Isett, Christopher Deitrick, Aofei Li, Marion Joy, Carly Reeder, Katelyn Smith, Julie Urban, Lorenzo Sellitto, Mark Jelinek, Susan M Christner, Jan H Beumer, Liza C Villaruz, 

Thymidine rescues ATR kinase inhibitor-induced deoxyuridine contamination in genomic DNA, cell death, and interferon-α/β expression

胸苷可挽救ATR激酶抑制剂诱导的基因组DNA中脱氧尿苷污染、细胞死亡和干扰素-α/β表达。

Norie Sugitani ,Frank P Vendetti ,Andrew J Cipriano ,Pinakin Pandya ,Joshua J Deppas ,Tatiana N Moiseeva ,Sandra Schamus-Haynes ,Yiyang Wang ,Drake Palmer ,Hatice U Osmanbeyoglu ,Anna Bostwick ,Nathaniel W Snyder ,Yi-Nan Gong ,Katherine M Aird ,Greg M Delgoffe ,Jan H Beumer ,Christopher J Bakkenist

Dose-dependent bioavailability, absorption-rate limited elimination, and tissue distribution of the ATR inhibitor BAY-1895344 (elimusertib) in mice

ATR 抑制剂 BAY-1895344 (elimusertib) 在小鼠体内的剂量依赖性生物利用度、吸收速率受限消除和组织分布

Brian F Kiesel, Joshua J Deppas, Jianxia Guo, Robert A Parise, David A Clump, Christopher J Bakkenist, Jan H Beumer

Dose-dependent bioavailability and tissue distribution of the ATR inhibitor AZD6738 (ceralasertib) in mice

ATR 抑制剂 AZD6738 (ceralasertib) 在小鼠体内的剂量依赖性生物利用度和组织分布

Brian F Kiesel, Jianxia Guo, Robert A Parise, Raman Venkataramanan, David A Clump, Christopher J Bakkenist, Jan H Beumer

Quantitation of the ataxia-telangiectasia-mutated and Rad3-related inhibitor elimusertib (BAY-1895344) in human plasma using LC-MS/MS

使用 LC-MS/MS 对人血浆中的毛细血管扩张性共济失调突变和 Rad3 相关抑制剂 elimusertib (BAY-1895344) 进行定量分析

Brian F Kiesel, Robert A Parise, Anuradha Krishnamurthy, Steven Gore, Jan H Beumer

ALDH1A1 Gene Expression and Cellular Copper Levels between Low and Highly Metastatic Osteosarcoma Provide a Case for Novel Repurposing with Disulfiram and Copper

低转移性骨肉瘤和高转移性骨肉瘤之间的 ALDH1A1 基因表达和细胞铜水平为双硫仑和铜的新用途提供了案例

Jonathan B Mandell, Nerone Douglas, Vrutika Ukani, Jan H Beumer, Jianxia Guo, John Payne, Rebecca Newman, Luigi Mancinelli, Giuseppe Intini, Carolyn J Anderson, Rebecca Watters, Kurt Weiss

Dasatinib and dexamethasone followed by hematopoietic cell transplantation for adults with Ph-positive ALL

达沙替尼和地塞米松治疗,随后进行造血细胞移植,治疗 Ph 阳性 ALL 成人患者

Matthew J Wieduwilt, Jun Yin, Meir Wetzler, Geoffrey L Uy, Bayard L Powell, Jonathan E Kolitz, Michaela Liedtke, Wendy Stock, Jan H Beumer, Ryan J Mattison, Elizabeth Storrick, Susan M Christner, Lionel D Lewis, Steven Devine, Richard M Stone, Richard A Larson

Improved chemosensitivity following mucolytic therapy in patient-derived models of mucinous appendix cancer

粘液溶解疗法在患者来源的粘液性阑尾癌模型中改善了化学敏感性

Ashok K Dilly, Brendon D Honick, Robin Frederick, Anuleka Elapavaluru, Sachin Velankar, Hima Makala, T Kevin Hitchens, Lesley M Foley, Jianxia Guo, Jan H Beumer, Lora Heather Rigatti, Yong J Lee, David L Bartlett, Haroon A Choudry