日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling

孤儿G蛋白偶联受体GPRC5B通过促进前列腺素E受体2信号传导来控制巨噬细胞功能

Jeonghyeon Kwon ,Haruya Kawase ,Kenny Mattonet ,Stefan Guenther ,Lisa Hahnefeld ,Jamal Shamsara ,Jan Heering ,Michael Kurz ,Sina Kirchhofer ,Cornelius Krasel ,Michaela Ulrich ,Margherita Persechino ,Sripriya Murthy ,Cesare Orlandi ,Christian D Sadik ,Gerd Geisslinger ,Moritz Bünemann ,Peter Kolb ,Stefan Offermanns ,Nina Wettschureck

Structure-Based Design of PROTACS for the Degradation of Soluble Epoxide Hydrolase.

基于结构的PROTACS设计用于降解可溶性环氧化物水解酶

Schönfeld Julia, Brunst Steffen, Ciomirtan Ludmila, Willmer Lena, Chromik Michel A, Kumar Adarsh, Froemel Timo, Liebisch Nick, Hackspacher Arne, Ehrler Johanna H M, Wintermeier Lukas, Hesse Christina, Fiedler Jan, Heering Jan, Freitag Hinrich, Zardo Patrick, Fieguth Hans-Gerd, Brüggerhoff Astrid, Jakob Josefine, Häupl Björn, Weizel Lilia, Kaiser Astrid, Schubert-Zsilavecz Manfred, Oellerich Thomas, Fleming Ingrid, Schebb Nils H, Fürst Robert, Kannt Aimo, Knapp Stefan, Proschak Ewgenij, Hiesinger Kerstin

Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets

对用于降解剂开发的 LC3/GABARAP 配体和 LC3/GABARAP 结合位点的配体能力进行严格评估

Martin P Schwalm, Johannes Dopfer, Adarsh Kumar, Francesco A Greco, Nicolas Bauer, Frank Löhr, Jan Heering, Sara Cano-Franco, Severin Lechner, Thomas Hanke, Ivana Jaser, Viktoria Morasch, Christopher Lenz, Daren Fearon, Peter G Marples, Charles W E Tomlinson, Lorene Brunello, Krishna Saxena, Nathan

Oleic acid released by sensory neurons inhibits TRPV1-mediated thermal hypersensitivity via GPR40

感觉神经元释放的油酸通过 GPR40 抑制 TRPV1 介导的热超敏反应

Maksim Sendetski, Saskia Wedel, Kenta Furutani, Lisa Hahnefeld, Carlo Angioni, Jan Heering, Béla Zimmer, Sandra Pierre, Alexandra-Maria Banica, Klaus Scholich, Sorin Tunaru, Gerd Geisslinger, Ru-Rong Ji, Marco Sisignano

HTRF-based assay for detection of mono-ADP-ribosyl hydrolyzing macrodomains and inhibitor screening

基于 HTRF 的单 ADP 核糖基水解大结构域检测及抑制剂筛选的分析

Niklas Ildefeld, Dieter Steinhilber, Ewgenij Proschak, Jan Heering

SPMs exert anti-inflammatory and pro-resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor

SPM 通过对前列腺素 EP4 受体进行正向变构调节,发挥抗炎和促消退作用

Mohamad Wessam Alnouri, Kenneth Anthony Roquid, Rémy Bonnavion, Haaglim Cho, Jan Heering, Jeonghyeon Kwon, Yannick Jäger, ShengPeng Wang, Stefan Günther, Nina Wettschureck, Gerd Geisslinger, Robert Gurke, Christa E Müller, Ewgenij Proschak, Stefan Offermanns

Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch

发现 Slack (Kcnt1) 钾通道的小分子激活剂,可显著减少组胺非依赖性和慢性瘙痒小鼠模型中的抓挠行为

Annika Balzulat, W Felix Zhu, Cathrin Flauaus, Victor Hernandez-Olmos, Jan Heering, Sunesh Sethumadhavan, Mariam Dubiel, Annika Frank, Amelie Menge, Maureen Hebchen, Katharina Metzner, Ruirui Lu, Robert Lukowski, Peter Ruth, Stefan Knapp, Susanne Müller, Dieter Steinhilber, Inga Hänelt, Holger Stark

Druggability Evaluation of the Neuron Derived Orphan Receptor (NOR-1) Reveals Inverse NOR-1 Agonists

神经元衍生的孤儿受体 (NOR-1) 的药物可行性评估揭示了 NOR-1 的反向激动剂

Daniel Zaienne, Silvia Arifi, Julian A Marschner, Jan Heering, Daniel Merk

Scaffold Hopping from Amodiaquine to Novel Nurr1 Agonist Chemotypes via Microscale Analogue Libraries

通过微尺度类似物库实现从阿莫地喹到新型 Nurr1 激动剂化学型的骨架跳跃

Sabine Willems, Marcel Müller, Julia Ohrndorf, Jan Heering, Ewgenij Proschak, Daniel Merk

Nurr1 Modulation Mediates Neuroprotective Effects of Statins

Nurr1 调节介导他汀类药物的神经保护作用

Sabine Willems, Julian A Marschner, Whitney Kilu, Giuseppe Faudone, Romy Busch, Silke Duensing-Kropp, Jan Heering, Daniel Merk