Janda Kim D相关文献与解析，生知库 | 链接生命科学的每一步

Investigations of Thiosemicarbazides as Botulinum Toxin Active-Site Inhibitors: Enzyme, Cellular, and Rodent Intoxication Studies

硫代氨基脲类化合物作为肉毒杆菌毒素活性位点抑制剂的研究：酶、细胞和啮齿动物中毒研究

Patel, Ealin N; Lin, Lucy; Park, Hyeri; Sneller, Molly M; Eubanks, Lisa M; Tepp, William H; Pellet, Sabine; Janda, Kim D

细胞生物学

发表日期：2024

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Demystifying the Druggability of the MYC Family of Oncogenes

揭开MYC家族癌基因可成药性的神秘面纱

期刊:Journal of the American Chemical Society

影响因子:15.6

doi:10.1021/jacs.2c12732

Karadkhelkar, Nishant M; Lin, Mingliang; Eubanks, Lisa M; Janda, Kim D

Pharmacological GHSR (ghrelin receptor) blockade reduces alcohol binge-like drinking in male and female mice

药理学阻断生长激素释放肽受体（GHSR）可减少雄性和雌性小鼠的酒精暴饮行为。

期刊:Neuropharmacology

影响因子:4.6

doi:10.1016/j.neuropharm.2023.109643

Richardson, Rani S; Sulima, Agnieszka; Rice, Kenner C; Kucharczk, Jed A; Janda, Kim D; Nisbett, Khalin E; Koob, George F; Vendruscolo, Leandro F; Leggio, Lorenzo

Development of an Effective Monoclonal Antibody against Heroin and Its Metabolites Reveals Therapies Have Mistargeted 6-Monoacetylmorphine and Morphine over Heroin

针对海洛因及其代谢物开发出一种有效的单克隆抗体，揭示了现有疗法一直以来错误地靶向了6-单乙酰吗啡和吗啡，而非海洛因。

期刊:ACS Central Science

影响因子:10.4

doi:10.1021/acscentsci.2c00977

Lee, Jinny Claire; Eubanks, Lisa M; Zhou, Bin; Janda, Kim D

Identification of Slow-Binding Inhibitors of the BoNT/A Protease

鉴定肉毒杆菌毒素A蛋白酶的慢结合抑制剂

期刊:ACS Medicinal Chemistry Letters

影响因子:4

doi:10.1021/acsmedchemlett.2c00028

Patel, Ealin N; Turner, Lewis D; Hixon, Mark S; Janda, Kim D

发表日期：2022

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Identification of 3-hydroxy-1,2-dimethylpyridine-4(1H)-thione as a metal-binding motif for the inhibition of botulinum neurotoxin A

鉴定出 3-羟基-1,2-二甲基吡啶-4(1H)-硫酮为抑制肉毒杆菌神经毒素 A 的金属结合基序

期刊:RSC Medicinal Chemistry

影响因子:3.6

doi:10.1039/d0md00320d

Lin, Lucy; Turner, Lewis D; Šilhár, Peter; Pellett, Sabine; Johnson, Eric A; Janda, Kim D

发表日期：2021

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Irreversible inhibition of BoNT/A protease: proximity-driven reactivity contingent upon a bifunctional approach

BoNT/A蛋白酶的不可逆抑制：邻近驱动的反应性取决于双功能方法

期刊:RSC Medicinal Chemistry

影响因子:3.6

doi:10.1039/d1md00089f

Turner, Lewis D; Nielsen, Alexander L; Lin, Lucy; Pellett, Sabine; Sugane, Takashi; Olson, Margaret E; Johnson, Eric A; Janda, Kim D

发表日期：2021

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Fentanyl-Rewired: A 2‑Azaspiro[3.3]heptane Core Preserves μ‑Opioid Function

芬太尼重塑：2-氮杂螺[3.3]庚烷核心保留μ-阿片功能

Solid-phase synthesis of a pyrrole library and identification of bioactive compounds

吡咯化合物库的固相合成及生物活性化合物的鉴定

Discovery of PLD4 modulators by high-throughput screening and kinetic analysis

通过高通量筛选和动力学分析发现PLD4调节剂

Investigations of Thiosemicarbazides as Botulinum Toxin Active-Site Inhibitors: Enzyme, Cellular, and Rodent Intoxication Studies

硫代氨基脲类化合物作为肉毒杆菌毒素活性位点抑制剂的研究：酶、细胞和啮齿动物中毒研究

Demystifying the Druggability of the MYC Family of Oncogenes

揭开MYC家族癌基因可成药性的神秘面纱

Pharmacological GHSR (ghrelin receptor) blockade reduces alcohol binge-like drinking in male and female mice

药理学阻断生长激素释放肽受体（GHSR）可减少雄性和雌性小鼠的酒精暴饮行为。

Development of an Effective Monoclonal Antibody against Heroin and Its Metabolites Reveals Therapies Have Mistargeted 6-Monoacetylmorphine and Morphine over Heroin

针对海洛因及其代谢物开发出一种有效的单克隆抗体，揭示了现有疗法一直以来错误地靶向了6-单乙酰吗啡和吗啡，而非海洛因。

Identification of Slow-Binding Inhibitors of the BoNT/A Protease

鉴定肉毒杆菌毒素A蛋白酶的慢结合抑制剂

Identification of 3-hydroxy-1,2-dimethylpyridine-4(1H)-thione as a metal-binding motif for the inhibition of botulinum neurotoxin A

鉴定出 3-羟基-1,2-二甲基吡啶-4(1H)-硫酮为抑制肉毒杆菌神经毒素 A 的金属结合基序

Irreversible inhibition of BoNT/A protease: proximity-driven reactivity contingent upon a bifunctional approach

BoNT/A蛋白酶的不可逆抑制：邻近驱动的反应性取决于双功能方法