日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A stress-dependent TDP-43 SUMOylation program preserves neuronal function

应激依赖性TDP-43 SUMO化程序维持神经元功能

Terry R Suk ,Caroline E Part ,Jenny L Zhang # ,Trina T Nguyen # ,Meghan M Heer ,Alejandro Caballero-Gómez ,Veronica S Grybas ,Paul M McKeever ,Benjamin Nguyen ,Tahir Ali ,Steve M Callaghan ,John M Woulfe ,Janice Robertson ,Maxime W C Rousseaux

C9orf72 deficiency impairs the autophagic response to aggregated TDP-25 and exacerbates TDP-25-mediated neurodegeneration in vivo

C9orf72缺陷会损害对聚集的TDP-25的自噬反应,并加剧体内TDP-25介导的神经退行性变。

Lilian Tsai-Wei Lin ,Marc Shenouda ,Philip McGoldrick ,Agnes Lau ,Janice Robertson

Loss of C9orf72 perturbs the Ran-GTPase gradient and nucleocytoplasmic transport, generating compositionally diverse Importin β-1 granules

C9orf72 的缺失会扰乱 Ran-GTPase 梯度和核质运输,从而产生成分多样的 Importin β-1 颗粒

Philip McGoldrick, Agnes Lau, Zhipeng You, Thomas M Durcan, Janice Robertson

A C-Terminally Truncated TDP-43 Splice Isoform Exhibits Neuronal Specific Cytoplasmic Aggregation and Contributes to TDP-43 Pathology in ALS

端截短的 TDP-43 剪接异构体表现出神经元特异性细胞质聚集,并导致 ALS 中的 TDP-43 病理

Marc Shenouda, Shangxi Xiao, Laura MacNair, Agnes Lau, Janice Robertson

The FUS gene is dual-coding with both proteins contributing to FUS-mediated toxicity

FUS 基因具有双重编码,两种蛋白质均会导致 FUS 介导的毒性

Marie A Brunet, Jean-Francois Jacques, Sonya Nassari, Giulia E Tyzack, Philip McGoldrick, Lorne Zinman, Steve Jean, Janice Robertson, Rickie Patani, Xavier Roucou

TNF receptor-associated factor 6 interacts with ALS-linked misfolded superoxide dismutase 1 and promotes aggregation

TNF受体相关因子6与ALS相关的错误折叠超氧化物歧化酶1相互作用并促进其聚集

Sabrina Semmler,Myriam Gagné,Pranav Garg,Sarah R Pickles,Charlotte Baudouin,Emeline Hamon-Keromen,Laurie Destroismaisons,Yousra Khalfallah,Mathilde Chaineau,Elise Caron,Andrew N Bayne,Jean-François Trempe,Neil R Cashman,Alexandra T Star,Arsalan S Haqqani,Thomas M Durcan,Elizabeth M Meiering,Janice Robertson,Nathalie Grandvaux,Steven S Plotkin,Heidi M McBride,Christine Vande Velde

Neuropathologic description of CHCHD10 mutated amyotrophic lateral sclerosis

CHCHD10 突变型肌萎缩侧索硬化症的神经病理学描述

Julia L Keith, Emily Swinkin, Andrew Gao, Samira Alminawi, Ming Zhang, Philip McGoldrick, Paul McKeever, Janice Robertson, Ekaterina Rogaeva, Lorne Zinman

ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD

C9orf72介导的ALS/FTD中ADAR2错位和广泛的RNA编辑异常

Stephen Moore,Eric Alsop,Ileana Lorenzini,Alexander Starr,Benjamin E Rabichow,Emily Mendez,Jennifer L Levy,Camelia Burciu,Rebecca Reiman,Jeannie Chew,Veronique V Belzil,Dennis W Dickson,Janice Robertson,Kim A Staats,Justin K Ichida,Leonard Petrucelli,Kendall Van Keuren-Jensen,Rita Sattler

Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72

抗体表征程序的实施及其对主要 ALS/FTD 疾病基因 C9ORF72 的应用

Carl Laflamme, Paul M McKeever, Rahul Kumar, Julie Schwartz, Mahshad Kolahdouzan, Carol X Chen, Zhipeng You, Faiza Benaliouad, Opher Gileadi, Heidi M McBride, Thomas M Durcan, Aled M Edwards, Luke M Healy, Janice Robertson, Peter S McPherson

Synaptic localization of C9orf72 regulates post-synaptic glutamate receptor 1 levels

C9orf72 的突触定位调节突触后谷氨酸受体 1 的水平

Shangxi Xiao, Paul M McKeever, Agnes Lau, Janice Robertson