日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3.

单价伪天然产物可加速 IDO1 的天然 E3 KLHDC3 的降解。

Hennes Elisabeth, Lucas Belén, Scholes Natalie S, Cheng Xiu-Fen, Scott Daniel C, Bischoff Matthias, Reich Katharina, Gasper Raphael, Lucas María, Xu Teng Teng, Rossini Sofia, Pulvermacher Lisa-Marie, Dötsch Lara, Imrichova Hana, Brause Alexandra, Führer Siska, Naredla Kesava Reddy, Sievers Sonja, Kumar Kamal, Janning Petra, Orabona Ciriana, Gersch Malte, Murray Peter J, Schulman Brenda A, Winter Georg E, Ziegler Slava, Waldmann Herbert

Design, Synthesis, and Structural Evolution of Pseudo-Natural Product IDO1 Inhibitors and Degraders

拟天然产物IDO1抑制剂和降解剂的设计、合成和结构演变

Cheng, Xiu-Fen; Lucas, Belén; Lampe, Philipp; Ugel, Stefano; Chen, Suyuan; Unger, Anke; Bischoff, Matthias; Adariani, Soheila Rezaei; Naredla, Kesava Reddy; Kumar, Kamal; Schmidt, Annika; Strohmann, Carsten; Janning, Petra; Gasper, Raphael; Lucas, María; Gersch, Malte; Sievers, Sonja; Bronte, Vincenzo; Ziegler, Slava; Waldmann, Herbert

Covalent modification of a glutamic acid inspired by HaloTag technology.

受 HaloTag 技术启发,对谷氨酸进行共价修饰。

Zhang Ruirui, Liu Jie, Gasper Raphael, Unger Anke, Kaschani Farnusch, Kaiser Markus, Janning Petra, Waldmann Herbert

RPA directly stimulates Mer3 helicase processivity to ensure normal crossover formation in meiosis.

RPA 直接刺激 Mer3 解旋酶的持续活性,以确保减数分裂中正常的交叉形成。

Altmannova Veronika, Orlić Lucija, Carrasco Carolina, Adam Céline, Aicart-Ramos Clara, Guerrini Dario, Janning Petra, Borde Valérie, Matos Joao, Moreno-Herrero Fernando, Weir John R

Mammalian Proteome Profiling Reveals Readers and Antireaders of Strand-Symmetric and -Asymmetric 5-Hydroxymethylcytosine-Modifications in DNA

哺乳动物蛋白质组分析揭示了DNA中链对称和链不对称5-羟甲基胞嘧啶修饰的读取器和反读取器

Engelhard, Lena; Cakil, Zeyneb Vildan; Zambrano-Mila, Marlon S; Eppmann, Simone; Gonzalez, Tye; Linser, Rasmus; Janning, Petra; Becker, Sidney; Summerer, Daniel

M18BP1 valency and a distributed interaction footprint determine epigenetic centromere specification in humans.

M18BP1 价态和分布式相互作用足迹决定了人类的表观遗传着丝粒特化。

Walstein Kai, Hill Louisa, Vogt Doro, Oberste-Lehn Lina, Janning Petra, Vetter Ingrid R, Pan Dongqing, Musacchio Andrea

Targeting a Glutamic Acid in PDEδ with Fluoromethyl-Aryl Electrophiles Impairs K-Ras Signaling

用氟甲基-芳基亲电试剂靶向PDEδ中的谷氨酸会损害K-Ras信号传导

Zhang, Ruirui; Huetzen, Maxim A; Binici, Aylin; Martín-Gago, Pablo; Gasper, Raphael; Rudashevskaya, Elena; Liu, Jie; Nagaraju, Chinta; Reckzeh, Elena S; Stuedle, Alana S T; Hopff, Ann-Sophie; Mesaros, Andrea; Unger, Anke; Thelen, Melanie; Janning, Petra; Reinhardt, H Christian; Ziegler, Slava; Jachimowicz, Ron D; Waldmann, Herbert

Small Molecule-Induced Alterations of Protein Polyubiquitination Revealed by Mass-Spectrometric Ubiquitome Analysis

质谱泛素组分析揭示小分子诱导的蛋白质多聚泛素化改变

Führer, Siska; Gallant, Kai; Kaschani, Farnusch; Kaiser, Markus; Janning, Petra; Waldmann, Herbert; Gersch, Malte

Bemcentinib as monotherapy and in combination with low-dose cytarabine in acute myeloid leukemia patients unfit for intensive chemotherapy: a phase 1b/2a trial

贝莫替尼单药治疗及联合低剂量阿糖胞苷治疗不适合接受强化化疗的急性髓系白血病患者:一项 1b/2a 期试验

Loges, Sonja; Heuser, Michael; Chromik, Jörg; Sutamtewagul, Grerk; Kapp-Schwoerer, Silke; Crugnola, Monica; Di Renzo, Nicola; Lemoli, Roberto; Mattei, Daniele; Fiedler, Walter; Alvarado-Valero, Yesid; Ben-Batalla, Isabel; Waizenegger, Jonas; Rieckmann, Lisa-Marie; Janning, Melanie; Collienne, Maike; Imbusch, Charles D; Beumer, Niklas; Micklem, David; H Nilsson, Linn; Madeleine, Noëlly; McCracken, Nigel; Oliva, Cristina; Gorcea-Carson, Claudia; Gjertsen, Bjørn T

Clinical benefit of additional whole-exome sequencing over panel sequencing in an all-comer real-world molecular tumor board

在真实世界分子肿瘤委员会中,全外显子组测序相对于panel测序的临床获益

Krieghoff-Henning, E; Michaeli, T; Boch, T; Kirchhof, J; Haselmann, V; Neumaier, M; Hofmann, W-K; Betge, J; Ebert, M; Teufel, A; Ast, V; Sauer, C; Cotarelo, C; Lozynskyy, R; Janning, M; Marmé, F; Sütterlin, M; Streuer, A; Siegel, F; Brochhausen, C; Collienne, M; Nowak, D; Loges, S